{"id":284,"date":"2021-03-18T12:33:26","date_gmt":"2021-03-18T12:33:26","guid":{"rendered":"http:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/?page_id=284"},"modified":"2021-03-18T12:33:26","modified_gmt":"2021-03-18T12:33:26","slug":"replicative-stress-and-tumorigenesis","status":"publish","type":"page","link":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/replicative-stress-and-tumorigenesis\/","title":{"rendered":"Replicative stress and tumorigenesis"},"content":{"rendered":"

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Replicative stress and tumorigenesis<\/h1>\n<\/div>\n
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PRINCIPAL INVESTIGATOR<\/h4>\n\n\n\n
<\/td>\nRaimundo Freire Betancor, PhD<\/strong><\/p>\n

Contracted investigator SCS\/FIISC; HUC Research Unit<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Postdoctoral Collaborating Researchers:<\/strong><\/p>\n

    \n
  • Elisa Cabrera Afonso, PhD (Postdoctoral researcher, Fundaci\u00f3n Bioavance contract: Study of genomic instability involving ubiquitin hydrolases \u2013 \u201cEstudios de inestabilidad gen\u00f3mica que implican ubiquitin hidrolasas\u201d)<\/li>\n
  • Juan Ram\u00f3n Hern\u00e1ndez Fernaud, PhD (Postdoctoral researcher, contracted Asociaci\u00f3n Espa\u00f1ola Contra el Cancer\/FIISC: Role of UPR in DNA replication control \u2013 \u201cPapel de la UPR en el control de la replicaci\u00f3n del ADN\u201d)<\/li>\n<\/ul>\n

    PhD students and trainees:<\/strong><\/p>\n

      \n
    • Esperanza Hern\u00e1ndez Carralero (Role of Ubiquitin hydrolases in DNA replication control \u2013 Papel de Ubiquitin hidrolasas en el control de la replicaci\u00f3n del ADN. The Canary Islands Agency of Research, Innovation and Information Sciences, ACIISI)<\/li>\n<\/ul>\n

      Research Lines:<\/strong><\/p>\n

        \n
      • Study of new proteins controlling replication in human cells<\/li>\n
      • Study of the expression of replication proteins in cancer<\/li>\n
      • Determination of ubiquitin hydrolases involved in genomic instability in human cells<\/li>\n<\/ul>\n

        Funded projects:<\/strong><\/p>\n

          \n
        • Regulation of the cellular response to DNA damage and replicative stress: the molecular mechanism and implications for tumorigenesis (SAF2016-80626-R \u201cRegulaci\u00f3n de la respuesta celular al da\u00f1o del DNA y al estr\u00e9s replicativo: Mecanismos moleculares e implicaciones en tumorigenesis\u201d). PIs: Raimundo Freire, Veronique Smits. Ministry of Economy and Competitiveness, MINECO (2017-2019; extended until October 2020, 229,900 \u20ac).<\/li>\n<\/ul>\n

          Publications 2019:<\/strong><\/p>\n

            \n
          • Smits VAJ, Cabrera E, Freire R, Gillespie DA. Claspin – checkpoint adaptor and DNA replication factor. FEBS J. 2019 Feb;286(3):441-455. doi: 10.1111\/febs.14594<\/li>\n
          • Herruzo E,Santos B,Freire R,Carballo JA,San-Segundo PA.Characterization of Pch2 localization determinants reveals a nucleolar-independent role in the meiotic recombination checkpoint. 2019 Sep;128(3):297-316. doi:10.1007\/s00412-019-00696-7<\/li>\n
          • Cabrera E, Raninga P, Khanna K, Freire R. GSK3-\u03b2 stimulates claspin degradation via \u03b2-TrCP ubiquitin ligase and alters cancer cell survival. Cancers (Basel). 2019 Jul 29;11(8). doi: 10.3390\/cancers11081073<\/li>\n
          • Singh AN, Oehler J, Torrecilla I, Kilgas S, Li S, Vaz B, Gu\u00e9rillon C, Fielden J, Hernandez-Carralero E, Cabrera E, Tullis ID, Meerang M, Barber PR, Freire R, Parsons J, Vojnovic B, Kiltie AE, Mailand N, Ramadan K. The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8. EMBO J. 2019 Oct 4;38(21):e102361. doi: 10.15252\/embj.2019102361.<\/li>\n<\/ul>\n

            Other Selected publications from the last 10 years:<\/strong><\/p>\n

              \n
            • Cabrera E, Hern\u00e1ndez-P\u00e9rez S, Koundrioukoff S, Debatisse M, Kim D, Smolka MB, Freire R, Gillespie DA. PERK inhibits DNA replication during the Unfolded Protein Response via Claspin and Chk1. Oncogene. 2017 Feb 2;36(5):678-686. doi:10.1038\/onc.2016.239<\/li>\n
            • Hernandez-Perez S, Cabrera E, Salido E, Lim M, Reid L, Lakhani SR, Khanna KK, Saunus JM, Freire R. DUB3 and USP7 de-ubquitination enzymes control replication inhibitor Geminin: molecular characterization and association with breast cancer. Oncogene. 2017 Aug 17;36(33):4802-4809. doi: 10.1038\/onc.2017.21<\/li>\n
            • Hernandez-Perez S, Cabrera E, Amoedo H, Rodriguez-Acebes S, Koundrioukoff S, Debatisse M, Mendez J, Freire R. USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication. Mol Oncol. 2016 Oct;10(8):1196-206. doi:10.1016\/j.molonc.2016.05.008<\/li>\n
            • Mart\u00edn Y, Cabrera E, Amoedo H, Hern\u00e1ndez-P\u00e9rez S, Dom\u00ednguez-Kelly R, Freire R. USP29 controls the stability of checkpoint adaptor Claspin by deubiquitination. Oncogene. 2015 Feb 19;34(8):1058-63. doi: 10.1038\/onc.2014.38<\/li>\n
            • Dom\u00ednguez-Kelly R, Mart\u00edn Y, Koundrioukoff S, Tanenbaum ME, Smits VA, Medema RH, Debatisse M, Freire R. Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease. J Cell Biol. 2011 Aug 22;194(4):567-79. doi: 10.1083\/jcb.201101047<\/li>\n<\/ul>\n<\/div>\n

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              [vc_row][vc_column][vc_column_text] Replicative stress and tumorigenesis PRINCIPAL INVESTIGATOR Raimundo Freire Betancor, PhD Contracted investigator SCS\/FIISC; HUC Research Unit Postdoctoral Collaborating Researchers: Elisa Cabrera Afonso, PhD (Postdoctoral researcher, Fundaci\u00f3n Bioavance contract: Study of genomic instability involving ubiquitin hydrolases \u2013 \u201cEstudios de inestabilidad gen\u00f3mica que implican ubiquitin hidrolasas\u201d) Juan Ram\u00f3n Hern\u00e1ndez Fernaud, PhD (Postdoctoral researcher, contracted Asociaci\u00f3n Espa\u00f1ola…<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/template-no-title.php","meta":[],"_links":{"self":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages\/284"}],"collection":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/comments?post=284"}],"version-history":[{"count":1,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages\/284\/revisions"}],"predecessor-version":[{"id":285,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages\/284\/revisions\/285"}],"wp:attachment":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/media?parent=284"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}