{"id":319,"date":"2021-03-19T08:06:55","date_gmt":"2021-03-19T08:06:55","guid":{"rendered":"http:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/?page_id=319"},"modified":"2021-03-19T08:06:55","modified_gmt":"2021-03-19T08:06:55","slug":"chronic-kidney-disease-diabetes-and-kidney-transplant-complications","status":"publish","type":"page","link":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/chronic-kidney-disease-diabetes-and-kidney-transplant-complications\/","title":{"rendered":"Chronic kidney disease, diabetes and kidney transplant complications"},"content":{"rendered":"

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Chronic kidney disease, diabetes and kidney transplant complications<\/h1>\n<\/div>\n
\n

INVESTIGADORES RESPONSABLES<\/h4>\n\n\n\n
<\/td>\nEsteban Porrini, MD, PhD<\/strong><\/p>\n

(\u201cRam\u00f3n y Cajal\u201d Investigator, Department of Internal Medicine, Dermatology and Psychiatry, ULL<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
<\/td>\nArmando Torres Ram\u00edrez, MD, PhD<\/strong><\/p>\n

Professor of Medicine, Department of Internal Medicine, Dermatology and Psychiatry, ULL \u2013 Head of Nephrology Service, HUC<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

CLINICAL COLLABORATORS:<\/h4>\n
    \n
  • Alejandra \u00c1lvarez, MD (HUC)<\/li>\n
  • Ana Gonz\u00e1lez Rinne, MD (HUC)<\/li>\n
  • Beatriz Escamilla, MD (HUC)<\/li>\n
  • Domingo Marrero Miranda, MD (HUC)<\/li>\n
  • Lourdes P\u00e9rez Tamaj\u00f3n, MD (HUC)<\/li>\n
  • Patricia Delgado Mallen, MD (HUC)<\/li>\n
  • Sara Estupi\u00f1\u00e1n, MD (HUC)<\/li>\n<\/ul>\n

    EXTERNAL POSTDOCTORAL COLLABORATORS:<\/h4>\n
      \n
    • Sergio Luis Lima, PhD (RedInRen Contracted Investigator, ISCIII)<\/li>\n
    • Ana Elena Rodr\u00edguez Rodr\u00edguez, PhD (Contracted Investigator FGULL)<\/li>\n
    • Javier Donate Correa, PhD (ISCIII \u201cSara Borrell\u201d Programme, FIISC)<\/li>\n
    • Marian Cobo Caso, PhD (HUC)<\/li>\n
    • Rosa Miquel, PhD (HUC)<\/li>\n<\/ul>\n

      PHD STUDENTS AND TRAINEES:<\/h4>\n
        \n
      • Ra\u00fal Morales Febles: Exercise and prediabetes after transplantation (PFIS 17\/00303)<\/li>\n
      • Carlos Gonz\u00e1lez Alay\u00f3n: Estimated and measured GFR in cirrhosis<\/li>\n
      • Pablo Jorge P\u00e9rez: Estimated and measured GFR in acute heart failure<\/li>\n
      • Germ\u00e1n P\u00e9rez Su\u00e1rez: Evolution of bone mineral density and prevalence of renal lithiasis in adult patients diagnosed with idiopathic hypercalciuria in childhood (\u201cEvoluci\u00f3n de la densidad mineral \u00f3sea y prevalencia de litiasis renal en pacientes adultos diagnosticados de hipercalciuria idiop\u00e1tica en la infancia\u201d)<\/li>\n<\/ul>\n

        TECHNICAL AND ADMINISTRATIVE STAFF:<\/h4>\n
          \n
        • Federico Gonz\u00e1lez Rinne (Informatician UCICEC-HUC)<\/li>\n
        • Natalia Negr\u00edn Mena (Contracted Research Network RedInRen, ISCIII)<\/li>\n<\/ul>\n

          RESEARCH LINES:<\/h4>\n

          Our aim is to study strategies to prevent the deterioration of kidney function in chronic kidney disease (CKD), and the metabolic and cardiovascular complications associated with kidney transplants. We analyse the impact of diabetes, obesity, metabolic syndrome and insulin resistance on CKD.<\/p>\n

          Regarding kidney transplantation, we concentrate on the study of post-transplantation diabetes and pre-diabetes. We are interested in epidemiological studies as a proof of concept for randomised clinical trials, and in the use of animal models to study new preventive effects of immunosuppressant drugs with pro-diabetic actions.<\/p>\n

          FUNDED PROJECTS:<\/h4>\n
            \n
          • Loss of kidney function in the absence of proteinuria in type 2 diabetic women (PI16\/01814 – La p\u00e9rdida de la funci\u00f3n renal en ausencia de proteinuria en mujeres con diabetes tipo 2\u201d). PI: Esteban Porrini. Institute of Health Carlos III (2017-2020, 113,437.50 \u20ac).<\/li>\n
          • Pre-donation kidney reserve: impact on the donor and receptor kidney function in a live donor kidney transplant programme (PIFUN18\/17 \u2013 \u201cReserva renal predonaci\u00f3n: impacto en la evoluci\u00f3n de la funci\u00f3n renal del donante y receptor en un programa de trasplante renal de donante vivo\u201d). PIs: Ana Gonz\u00e1lez Rinne and Esteban Porrini. The Canary Islands Foundation for Medical Research, FUNCANIS (2018-2020, 30,000 \u20ac).<\/li>\n
          • National \u201cRam\u00f3n y Cajal\u201d programme. Postdoctoral contracts for Research and Development centres (RYC-2014-16573. \u201cDiabetic Nephropathy, Post-transplant diabetes\u201d). PI: Esteban Porrini. MINECO (Ram\u00f3n y Cajal Sub-programme; 2015-2020, 268.600 \u20ac -salary, 5 years+ 40,000 \u20ac, Research Project).<\/li>\n
          • REDINREN Kidney research Network: Transplant Program II. (RD16\/0009\/0031- \u201cRed Tem\u00e1tica de Investigaci\u00f3n Renal REDINREN: Programa II Trasplante\u201d). PI: Armando Torres. Institute of Health Carlos III (2017-2021, 102,300 \u20ac).<\/li>\n
          • New mechanisms of diabetogenicity for immunosuppressant drugs related to FKBP12 binding, the loss of B-cell identity and changes in insulin secretion (PI16\/02151 \u2013 \u201cNuevos mecanismos de diabetogenicidad de los inmunosupresores relacionados con su uni\u00f3n a FKBP12 p\u00e9rdida de identidad de la c\u00e9lula beta y cambios en la secreci\u00f3n de insulina\u201d). PI: Armando Torres. Institute of Health Carlos III (2017-2021, 121,302.50 \u20ac).<\/li>\n
          • The role of inflammation on prediabetes and diabetes alter renal transplantation; the beneficial effect of moderate exercise. (PI19\/01187). PI: Armando Torres. Institute of Health Carlos III (2019-2022, 62,315 \u20ac).<\/li>\n
          • Testing the efficacy of a flavonoid in renal disease. PI: Esteban Porrini. ARAFARMA (2019-2021, 90,000 \u20ac).<\/li>\n
          • Relationship between renal function to endothelial dysfunction in living donors, CONFUCIUS study. PI: Francisco Moreso \/ Esteban Porrini. TEVA laboratory (2018-2020, 46,000 \u20ac).<\/li>\n
          • Unmasking progressors towards chronic kidney disease in Autosomal Dominant Polycystic Kidney Disease (ADPKD) by measured renal function. Co-PI: Esteban Porrini. OTSUKA laboratory (2017-2020, 25,000 \u20ac).<\/li>\n
          • Efficacy of ENVARSUS in the prevention of PTDM. PI: Armando Torres. Co-PI: Esteban Porrini. Chiesi laboratory (2018-2021, 59.000 \u20ac).<\/li>\n
          • Preclinical development of a new drug for the treatment of hyperuricemia and hyperuremia (\u201cDesarrollo precl\u00ednico de un nuevo f\u00e1rmaco para el tratamiento de la hiperuricemia e hiperuremia\u201d: Exp. Matriz 19120187). PIs: Araceli Delgado, Esteban Porrini. Arafarma Group S.A., FGULL (2019-2020, 199,870 \u20ac).<\/li>\n<\/ul>\n

            PUBLICATIONS 2019:<\/h4>\n
              \n
            • Rodriguez-Rodriguez A, Donate-Correa J, Rovira J, Cuesto G, Luis-Ravelo D, Fernandes MX, Acevedo-Arozena A, Diekmann F, Acebes A, Torres A, Porrini E. Inhibition of the mTOR pathway: A new mechanism of \u03b2 cell toxicity induced by Tacrolimu Am J Transplant. 2019 Dec;19(12):3240-3249. doi: 10.1111\/ajt.15483<\/li>\n
            • Fernandez-Fernandez B, Fernandez-Prado R ,G\u00f3rriz JL,Martinez-Castelao A, Navarro-Gonz\u00e1lez JF,Porrini E,Soler MJ,Ortiz A.Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation and Study of Diabetic Nephropathy with Atrasentan: What was learned about the treatment of diabetic kidney disease with canagliflozin and atrasentan? Clin Kidney J. 2019 May 31;12(3):313-321. doi: 10.1093\/ckj\/sfz070<\/li>\n
            • Porrini E,Ruggenenti P,Luis-Lima S,Carrara F,Jim\u00e9nez A,de Vries APJ,Torres A,Gaspari F,Remuzzi G. Estimated GFR: time for a critical appraisal. Nat Rev Nephrol. 2019 Mar;15(3):177-190. doi: 10.1038\/s41581-018-0080-9<\/li>\n
            • Sarafidis P,Ferro CJ,Morales E,Ortiz A,Malyszko J,Hojs R,Khazim K,Ekart R, Valdivielso J,Fouque D,London GM,Massy Z,Ruggenenti P,Porrini E,Wiecek A, Zoccali C,Mallamaci F,Hornum M SGLT-2 inhibitors and GLP-1 receptor agonists for nephroprotection and cardioprotection in patients with diabetes mellitus and chronic kidney disease. A consensus statement by the EURECA-m and the DIABESITY working groups of the ERA-EDTA. Nephrol Dial Transplant. 2019 Feb 1;34(2):208-230. doi: 10.1093\/ndt\/gfy407<\/li>\n
            • Luis-Lima S,Escamilla-Cabrera B,Negr\u00edn-Mena N,Estupi\u00f1\u00e1n S,Delgado-Mall\u00e9n P,Marrero-Miranda D,Gonz\u00e1lez-Rinne A,Miquel-Rodr\u00edguez R, Cobo-CasoM\u00c1,Hern\u00e1ndez-Guerra M, Oramas J, Batista N,Aldea-Perona A,Jorge-P\u00e9rez P,Gonz\u00e1lez-Alay\u00f3n C,Moreno-Sanfiel M,Gonz\u00e1lez-Rodr\u00edguez JA,Henr\u00edquez L, Alonso-Pescoso R,D\u00edaz-Mart\u00edn L,Gonz\u00e1lez-Rinne F,Lav\u00edn-G\u00f3mez BA,Galindo-Hern\u00e1ndez J,S\u00e1nchez-Gallego M,Gonz\u00e1lez-Delgado A,Jim\u00e9nez-Sosa A,Torres A,Porrini E. Chronic kidney disease staging with cystatin C or creatinine-based formulas: Flipping the coin. Nephrol Dial Transplant. 2019 Feb 1;34(2):287-294. doi: 10.1093\/ndt\/gfy086<\/li>\n
            • Bettiga A,Fiorio F,Di Marco F,Trevisani F,Romani A,Porrini E,Salonia A,Montorsi F, Vago R.The modern western diet rich in advanced glycation end-products (AGEs): An overview of its impact on obesity and early progression of renal pathology. 2019 Jul 30;11(8). pii: E1748. doi: 10.3390\/nu11081748<\/li>\n
            • Gonz\u00e1lez-Rinne A,Luis-Lima S,Escamilla B,Negr\u00edn-Mena N,Ram\u00edrez A,Morales A, Vega N,Garc\u00eda P,Cabello E,Marrero-Miranda D, Aldea-Perona A,Alvarez A, Abad MDC,P\u00e9rez-Tamaj\u00f3n L,Gonz\u00e1lez-Rinne F,Gonz\u00e1lez-Delgado A,D\u00edaz Mart\u00edn L, Jim\u00e9nez-Sosa A,Torres A,Porrini E. Impact of errors of creatinine and cystatin C equations in the selection of living kidney donors. Clin Kidney J. 2019 Mar 18;12(5):748-755. doi: 10.1093\/ckj\/sfz012<\/li>\n
            • Porrini E,D\u00edaz JM,Moreso F,Lauzurrica R,Ibernon M,Torres IS,Ruiz RB,Rodr\u00edguez Rodr\u00edguez AE,Mall\u00e9n PD,Bay\u00e9s-Gen\u00eds B,Gainza FJ,Osorio JM,Osuna A, Dom\u00ednguez R, Ruiz JC,Sosa AJ,Rinne AG, Miranda DM,Mac\u00edas M,Torres A. Prediabetes is a risk factor for cardiovascular disease following renal transplantation. Kidney Int. 2019 Dec;96(6):1374-1380. doi: 10.1016\/j.kint.2019.06.026<\/li>\n
            • Luis-Lima S, Higueras Linares T, Henr\u00edquez-G\u00f3mez L, Alonso-Pescoso R, Jimenez A, L\u00f3pez-Hijazo AM, Negr\u00edn-Mena N, Mart\u00edn C, S\u00e1nchez-Gallego M, Galindo Hern\u00e1ndez SJ, Socas Fern\u00e1ndez Del Castillo R, Castilla-Marrero M, Dom\u00ednguez Coello S, Vilchez de Le\u00f3n V, Valc\u00e1rcel-Lopez R, Insausti-Garmendia N, Escamilla B, Estupi\u00f1\u00e1n S, Delgado-Mall\u00e9n P, Armas-Padr\u00f3n AM, Marrero-Miranda D, Gonz\u00e1lez-Rinne A, Miquel Rodr\u00edguez RM, Cobo-Caso MA, D\u00edaz-Mart\u00edn L, Gonz\u00e1lez-Rinne F, Gonz\u00e1lez-Delgado A, L\u00f3pez-Mart\u00ednez M, Jim\u00e9nez-Sosa A, Torres A, Porrini E. The Error of Estimated GFR in Type 2 Diabetes Mellitus. J Clin Med. 2019 Sep 26;8(10). pii: E1543. doi: 10.3390\/jcm8101543<\/li>\n
            • L\u00f3pez-Mart\u00ednez M, Luis-Lima S, Morales E, Navarro-D\u00edaz M, Negr\u00edn-Mena N, Folgueras T, Escamilla B, Estupi\u00f1\u00e1n S, Delgado-Mall\u00e9n P, Marrero-Miranda D, Gonz\u00e1lez-Rinne A, Miquel-Rodr\u00edguez RM, Cobo-Caso MA, D\u00edaz-Mart\u00edn L, Jim\u00e9nez Sosa A, Gonz\u00e1lez-Rinne F, Torres A, Porrini E. The estimation of GFR and the adjustment for BSA in overweight and obesity: a dreadful combination of two errors. Int J Obes (Lond). 2019 Oct 22. doi: 10.1038\/s41366-019-0476-z. [Epub ahead of print]<\/li>\n<\/ul>\n

              OTHER SELECTED PUBLICATIONS FROM THE LAST 10 YEARS:<\/h4>\n
                \n
              • Porrini E, D\u00edaz JM, Moreso F, Delgado Mall\u00e9n PI, Silva Torres I, Ibernon M, Bay\u00e9s- Gen\u00eds B, Benitez-Ruiz R, Lampreabe I, Lauzurrica R, Osorio JM, Osuna A, Dom\u00ednguez-Roll\u00e1n R, Ruiz JC, Jim\u00e9nez-Sosa A, Gonz\u00e1lez-Rinne A, Marrero-Miranda D, Mac\u00eda M, Garc\u00eda J, Torres A. Clinical evolution of post-transplant diabetes mellitus. Nephrol Dial Transplant. 2016 Mar;31(3):495-505. doi:10.1093\/ndt\/gfv368<\/li>\n
              • Luis-Lima S, Rodr\u00edguez-Rodr\u00edguez AE, Martin-Higueras C, Sierra-Ramos C, Carrara F, Arnau MR, de la Rosa DA, Salido E, Gaspari F, Porrini E. Iohexol plasma clearance, a simple and reliable method to measure renal function in conscious mice. Pflugers Arch. 2016 Sep;468(9):1587-94. doi: 10.1007\/s00424-016-1843-4<\/li>\n
              • D\u2019Agati VD, Chagnac A, de Vries AP, Levi M, Porrini E, Herman-Edelstein M, Praga M. Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis. Nat Rev Nephrol. 2016 Aug;12(8):453-71. doi: 10.1038\/nrneph.2016.75<\/li>\n
              • Porrini E, Ruggenenti P, Mogensen C-E et al., for the ERA-EDTA Working Group Diabesity. A role for non-proteinuric pathways in loss of renal function in patients with type 2 diabetes? Lancet Diabetes Endocrinol. 2015 May;3(5):382-91. doi: 10.1016\/S2213-8587(15)00094-7<\/li>\n
              • Luis-Lima S, Gaspari F, Porrini E, Garcia-Gonzalez M, Batista N, Bosa-Ojeda F, Oramas J, Carrara F, Gonzalez-Posada JM, Marrero D, Salido E, Torres A, Jimenez-Sosa A. Measurement of glomerular filtration rate: Internal and external validations of the iohexol plasma clearance technique by HPLC. Clin Chim Acta. 2014 Mar 20;430:84-5. doi:10.1016\/j.cca.2013.12.028<\/li>\n
              • de Vries AP,Ruggenenti P,Ruan XZ,Praga M,Cruzado JM,Bajema IM,D\u2019AgatiVD,Lamb HJ,Pongrac Barlovic D,Hojs R,Abbate M,Rodriquez R,MogensenCE,Porrini E;ERA-EDTA Working Group Diabesity. Fatty kidney: emerging role of ectopic lipid in obesityrelated renal disease. Lancet Diabetes Endocrinol. 2014 May;2(5):417-26. doi: 10.1016\/S2213-8587(14)70065-8<\/li>\n
              • Rodr\u00edguez-Rodr\u00edguez AE, Trinanes J, Vel\u00e1zquez-Garc\u00eda S, Porrini E, Vega Prieto MJ, Diez Fuentes ML, Arevalo M, Salido Ruiz E, Torres A. The higher diabetogenic risk of tacrolimus depends on pre-existing insulin resistance. A study in obese and lean zucker rats. Am J Transplant. 2013 Jul;13(7):1665-75. doi: 10.1111\/ajt.12236<\/li>\n
              • Tri\u00f1anes J, Rodriguez-Rodriguez AE, Brito-Casillas Y, Wagner A, De Vries APJ, Cuesto G, Acebes A, Salido E, Torres A, Porrini E. Deciphering Tacrolimus-Induced Toxicity in Pancreatic \u03b2 Am J Transplant. 2017 Nov;17(11):2829-2840. doi:10.1111\/ajt.14323<\/li>\n<\/ul>\n<\/div>\n

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                [vc_row][vc_column][vc_column_text] Chronic kidney disease, diabetes and kidney transplant complications INVESTIGADORES RESPONSABLES Esteban Porrini, MD, PhD (\u201cRam\u00f3n y Cajal\u201d Investigator, Department of Internal Medicine, Dermatology and Psychiatry, ULL Armando Torres Ram\u00edrez, MD, PhD Professor of Medicine, Department of Internal Medicine, Dermatology and Psychiatry, ULL \u2013 Head of Nephrology Service, HUC CLINICAL COLLABORATORS: Alejandra \u00c1lvarez, MD (HUC)…<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/template-no-title.php","meta":[],"_links":{"self":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages\/319"}],"collection":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/comments?post=319"}],"version-history":[{"count":1,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages\/319\/revisions"}],"predecessor-version":[{"id":320,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages\/319\/revisions\/320"}],"wp:attachment":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/media?parent=319"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}