{"id":325,"date":"2021-03-19T08:13:10","date_gmt":"2021-03-19T08:13:10","guid":{"rendered":"http:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/?page_id=325"},"modified":"2021-03-19T08:16:26","modified_gmt":"2021-03-19T08:16:26","slug":"kidney-and-cardiovascular-disease-research","status":"publish","type":"page","link":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/kidney-and-cardiovascular-disease-research\/","title":{"rendered":"Kidney and cardiovascular disease research"},"content":{"rendered":"

[vc_row][vc_column][vc_column_text]<\/p>\n

\n

Kidney and cardiovascular disease research<\/h1>\n<\/div>\n
\n

PRINCIPAL INVESTIGATOR<\/h4>\n\n\n\n
<\/td>\nJuan Francisco Navarro Gonz\u00e1lez, MD, PhD<\/strong><\/p>\n

Head of Service Research Unit, HUNSC<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

EXTERNAL POSTDOCTORAL COLLABORATORS:<\/h4>\n
    \n
  • Javier Donate Correa. PhD in Biology. Postdoctoral Researcher. FIISC<\/li>\n
  • V\u00edctor Garc\u00eda Tagua. PhD in Molecular Biology and Biomedicine. Postdoctoral Researcher. FIISC<\/li>\n<\/ul>\n

    COLLABORATORS AND CLINICAL RESEARCHERS:<\/h4>\n
      \n
    • Nayra P\u00e9rez Delgado (Clinical Analysis Service)<\/li>\n
    • Carolina Hern\u00e1ndez Carballo (Internal Medicine)<\/li>\n
    • Sergio Rodr\u00edguez Ramos (Trasplant Coordination)<\/li>\n
    • Purificaci\u00f3n Cerro (Trasplant Coordination)<\/li>\n
    • \u00c1ngel L\u00f3pez Castillo (Vascular Surgery)<\/li>\n
    • Alejandro Delgado Molinos (Vascular Surgery)<\/li>\n
    • Victoria Castro (Pathological Anatomy)<\/li>\n
    • Carol Prieto Mor\u00edn (Clinical Analysis)<\/li>\n
    • Orlando Siverio Morales (Nephrology)<\/li>\n
    • Desir\u00e9e Luis Rodr\u00edguez (Nephrology)<\/li>\n<\/ul>\n

      PHD STUDENTS AND TRAINEES:<\/h4>\n
        \n
      • Ernesto Mart\u00edn N\u00fa\u00f1ez (PFIS, Institute of Health Carlos III, FI14\/00033)<\/li>\n
      • Carla Mar\u00eda Ferri (The Canary Islands Agency of Research, Innovation and Information Sciences, ACIISI, TESIS2018010110)<\/li>\n
      • V\u00edctor Garc\u00eda Tagua (Stop Fuga de Cerebros (\u00abStop Brain Drain\u00bb) Fellowship. Roche Pharma – FIISC, C16\/004)<\/li>\n<\/ul>\n

        RESEARCH LINES:<\/h4>\n
          \n
        • Diabetic kidney disease.<\/li>\n
        • Chronic kidney disease and complications.<\/li>\n
        • Role of inflammation in high prevalence diseases.<\/li>\n
        • System FGF23\/Klotho.<\/li>\n<\/ul>\n

          FUNDED PROJECTS:<\/h4>\n
            \n
          • The FGF23\/Klotho system as a predictor of cardiovascular morbidity and mortality (PI16\/00024 \u2013 \u201cSistema FGF23\/Klotho como predictor de morbi-mortalidad cardiovascular\u201d). PI: Juan Francisco Navarro. Institute of Health Carlos III (2017-2019, 50,215 \u20ac).<\/li>\n
          • Kidney research Network (REDINREN, RD16\/0009\/0022 \u2013 \u201cRed de Investigaci\u00f3n Renal\u201d). PI: Juan Francisco Navarro. Institute of Health Carlos III (2017-2021, 118,673.50 \u20ac).<\/li>\n
          • The FGF23\/Klotho system in subclinical atherosclerotic vascular disease. Pathophysiological implications and therapeutic approach (PI19\/00035 \u2013 \u00abSistema FGF23\/Klotho en la enfermedad vascular ateroscler\u00f3tica subcl\u00ednica. Implicaciones fisiopatol\u00f3gicas y aproximaci\u00f3n terap\u00e9utica). PI: Juan F. Navarro. Institute of Health Carlos III (2020-2022, 56,870 \u20ac).<\/li>\n<\/ul>\n

            PUBLICATIONS 2019:<\/h4>\n
              \n
            • Fernandez-Fernandez B, Fernandez-Prado R,G\u00f3rriz JL,Martinez-Castelao A, Navarro-Gonz\u00e1lez JF,Porrini E,Soler MJ,Ortiz A.Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation and Study of Diabetic Nephropathy with Atrasentan: What was learned about the treatment of diabetic kidney disease with canagliflozin and atrasentan? Clin Kidney J. 2019 May 31;12(3):313-321. doi: 10.1093\/ckj\/sfz070<\/li>\n
            • Heerspink HJL,Parving HH,Andress DL,Bakris G,Correa-Rotter R,Hou FF,KitzmanDW,Kohan D,Makino H,McMurray JJV,Melnick JZ,Miller MG,PergolaPE,Perkovic V,Tobe S, Yi T,Wigderson M,de Zeeuw D;SONAR Committees and Investigators (Navarro JF). Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial. 2019 May 11;393(10184):1937-1947. doi: 10.1016\/S0140-6736(19)30772-X<\/li>\n
            • Donate-Correa J,Mart\u00edn-N\u00fa\u00f1ez E,Hern\u00e1ndez-Carballo C,Ferri C,TaguaVG, Delgado-Molinos A,L\u00f3pez-Castillo \u00c1,Rodr\u00edguez-Ramos S,Cerro-L\u00f3pez P,L\u00f3pez-Tarruella VC,Felipe-Garc\u00eda R,Ar\u00e9valo-Gomez MA,P\u00e9rez-Delgado N,Mora-Fern\u00e1ndez C,Navarro-Gonz\u00e1lez JF.Fibroblast growth factor 23 expression in human calcified vascular tissues. Aging (Albany NY). 2019 Sep 22;11(18):7899-7913. doi: 10.18632\/aging.102297<\/li>\n
            • Valls J,Cambray S,P\u00e9rez-Guallar C,Bozic M,Berm\u00fadez-L\u00f3pez M,Fern\u00e1ndez E, Betriu \u00c0,Rodr\u00edguez I,Valdivielso JM, NEFRONA cohort (Navarro Gonz\u00e1lez JF). Association of candidate gene polymorphisms with chronic kidney disease: Results of a case-control analysis in the NEFRONA cohort. Front Genet. 2019 Feb 26;10:118. doi: 10.3389\/fgene.2019.00118<\/li>\n
            • P\u00e9rez-Morales RE, Del Pino MD, Valdivielso JM, Ortiz A, Mora-Fern\u00e1ndez C, Navarro-Gonz\u00e1lez JF. Inflammation in Diabetic Kidney Disease. Nephron. 2019;143(1):12-16. doi: 10.1159\/000493278<\/li>\n
            • Donate-Correa J, Garc\u00eda-Tagua V, Ferri CM, Mart\u00edn-N\u00fa\u00f1ez, E, Hern\u00e1ndez-Carballo C, Ure\u00f1a-Torres P, Ruiz-Ortega M, Ortiz A, Mora-Fern\u00e1ndez C, Navarro-Gonz\u00e1lez JF. Pentoxifylline for renal protection in diabetic kidney disease. A model of old drugs for new horizon J Clin Med. 2019 Feb 27;8(3). pii: E287. doi: 10.3390\/jcm8030287<\/li>\n
            • Donate-Correa J, Mart\u00edn-N\u00fa\u00f1ez E, Ferri C, Hern\u00e1ndez-Carballo C, Garc\u00eda-Tagua V, Delgado-Molinos A, L\u00f3pez-Castillo A, Rodr\u00edguez-Ramos S, Cerro-L\u00f3pez P, Castro L\u00f3pez-Tarruella V, Ar\u00e9valo-Gonz\u00e1lez MA, P\u00e9rez-Delgado N, Mora-Fern\u00e1ndez C, Navarro-Gonz\u00e1lez JF. FGF23 and Klotho levels are independently associated with diabetic foot s\u00edndrome in type 2 diabetes mellitus. J Clin Med. 2019 Apr 3;8(4). pii: E448. doi: 10.3390\/jcm8040448<\/li>\n
            • Mart\u00edn-N\u00fa\u00f1ez E, Donate-Correa J, Kannengiesser C, De Brauwere DP, Leroy C, Oudin C, Friedlander G, Prieto-Mor\u00edn C, Tagua VG, Ure\u00f1a-Torres PA, Navarro- Gonz\u00e1lez JF. A novel heterozygous deletion variant in KLOTHO gene leading to haploinsufficiency and impairment of fibroblast growth factor 23 signaling pathway. J Clin Med. 2019 Apr 12;8(4). pii: E500. doi: 10.3390\/jcm8040500<\/li>\n
            • Valdivielso JM, Bozic M, Galimudi RK, Berm\u00fadez-L\u00f3pez M, Navarro-Gonz\u00e1lez JF, Fern\u00e1ndez E, Betriu A, on behalf of the NEFRONA investigators. Association of the rs495392 Klotho polymorphism with atheromatosis progression in chronic kidney disease patients. Nephrol Dial Transplant. 2019 Dec 1;34(12):2079-2088. doi: 10.1093\/ndt\/gfy207<\/li>\n<\/ul>\n

              SELECTED PUBLICATIONS FROM THE LAST 10 YEARS:<\/h4>\n
                \n
              • Navarro-Gonz\u00e1lez JF, S\u00e1nchez-Ni\u00f1o MD, Donate-Correa J, Mart\u00edn-N\u00fa\u00f1ez E, Ferri C, P\u00e9rez-Delgado N, G\u00f3rriz JL, Mart\u00ednez-Castelao A, Ortiz A, Mora-Fern\u00e1ndez C. Effects of pentoxifylline on soluble Klotho concentrations and renal tubular cell expression in diabetic kidney disease. Diabetes Care. 2018 Aug;41(8):1817-1820. doi:10.2337\/dc18-0078<\/li>\n
              • Donate-Correa J, Henriquez-Palop F, Mart\u00edn-N\u00fa\u00f1ez E, P\u00e9rez-Delgado N, Muros-de-Fuentes M, Mora-Fernandez C, Navarro-Gonz\u00e1lez JF. Effect of Paricalcitol on FGF-23 and Klotho in kidney transplant recipients. 2016;100(11):2432-2438. doi: 10.1097\/TP.0000000000001339<\/li>\n
              • Donate-Correa J, Mart\u00edn-N\u00fa\u00f1ez E, Perez Delgado N, Muros de Fuentes M, Ortiz Arduan A, Mora-Fernandez C, Navarro-Gonzalez JF. Implications of fibroblast growth factor\/Klotho system in glucose metabolism and diabetes. Cytokine Growth Factor Rev. 2016 Apr;28:71-7. doi: 10.1016\/j.cytogfr.2015.12.003<\/li>\n
              • Donate-Correa J, Mart\u00edn-N\u00fa\u00f1ez E, Martinez-Sanz R, Muros de Fuentes M, Mora-Fernandez C, P\u00e9rez-Delgado N, Navarro-Gonz\u00e1lez JF. Influence of Klotho gene polymorphisms on vascular gene expression and its relationship to cardiovascular disease. J Cell Mol Med. 2016 Jan;20(1):128-33. doi: 10.1111\/jcmm.12710<\/li>\n
              • Navarro-Gonz\u00e1lez JF, Mora-Fern\u00e1ndez C, Muros de Fuentes M, Chahin J, M\u00e9ndez ML, Gallego E, Mac\u00eda M, del Castillo N, Rivero A, Getino MA, Garc\u00eda P, Jarque A, Garc\u00eda J. Effect of pentoxifylline on renal function and urinary albumin excretion in patients with diabetic kidney disease: the PREDIAN trial. J Am Soc Nephrol. 2015 Jan;26(1):220-9. doi: 10.1681\/ASN.2014010012<\/li>\n<\/ul>\n<\/div>\n

                [\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"

                [vc_row][vc_column][vc_column_text] Kidney and cardiovascular disease research PRINCIPAL INVESTIGATOR Juan Francisco Navarro Gonz\u00e1lez, MD, PhD Head of Service Research Unit, HUNSC EXTERNAL POSTDOCTORAL COLLABORATORS: Javier Donate Correa. PhD in Biology. Postdoctoral Researcher. FIISC V\u00edctor Garc\u00eda Tagua. PhD in Molecular Biology and Biomedicine. Postdoctoral Researcher. FIISC COLLABORATORS AND CLINICAL RESEARCHERS: Nayra P\u00e9rez Delgado (Clinical Analysis Service) Carolina…<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/template-no-title.php","meta":[],"_links":{"self":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages\/325"}],"collection":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/comments?post=325"}],"version-history":[{"count":4,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages\/325\/revisions"}],"predecessor-version":[{"id":329,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages\/325\/revisions\/329"}],"wp:attachment":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/media?parent=325"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}