{"id":330,"date":"2021-03-19T08:17:33","date_gmt":"2021-03-19T08:17:33","guid":{"rendered":"http:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/?page_id=330"},"modified":"2021-03-19T08:17:33","modified_gmt":"2021-03-19T08:17:33","slug":"inflammatory-response-and-tissue-damage-in-rheumatoid-arthritis","status":"publish","type":"page","link":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/inflammatory-response-and-tissue-damage-in-rheumatoid-arthritis\/","title":{"rendered":"Inflammatory response and tissue damage in rheumatoid arthritis"},"content":{"rendered":"

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Inflammatory response and tissue damage in rheumatoid arthritis<\/h1>\n<\/div>\n
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PRINCIPAL INVESTIGATOR<\/h4>\n\n\n\n
<\/td>\nJos\u00e9 Federico D\u00edaz Gonz\u00e1lez, MD, PhD<\/strong><\/p>\n

Professor of Medicine, Department of Internal Medicine, Dermatology and Psychiatry, ULL \u2013 Head of Rheumatology Service, HUC<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

POSTDOCTORAL CLINICAL COLLABORATORS:<\/h4>\n
    \n
  • Judith M\u00aa L\u00f3pez Fern\u00e1ndez, MD, PhD (Attending Physician, Endocrinology Service, HUC)<\/li>\n
  • Iv\u00e1n Ferraz Amaro, MD, PhD (Attending Physician, Rheumatology Service, HUC)<\/li>\n<\/ul>\n

    EXTERNAL POSTDOCTORAL COLLABORATORS:<\/h4>\n
      \n
    • Javier Rafael Castro Hern\u00e1ndez, PhD (PI Project: Role of autophagy in the regulation of intercellular junctions mediated by alpha 2 adrenergic receptors in endothelial cells. – \u00abPapel de la autofagia en la regulaci\u00f3n de las uniones intercelulares mediadas por los receptores alpha2 adren\u00e9rgicos en c\u00e9lulas endoteliales\u00bb FUNCANIS 24,500 \u20ac. 2018-2020)<\/li>\n<\/ul>\n

      PHD STUDENTS AND TRAINEES:<\/h4>\n
        \n
      • Mar\u00eda Teresa Arce Franco (Predoctoral Researcher, The Canary Islands Health Research Institute Foundation, FIISC. Role of Alpha 2 adrenergic receptor subtypes in the acute and joint inflammatory response\u00a0in vivo<\/em>\u00a0– \u00abPapel de los subtipos de receptores alpha2 adren\u00e9rgicos en la regulaci\u00f3n de la respuesta inflamatoria aguda y articular\u00a0in vivo<\/em>\u00ab).<\/li>\n
      • Sergio Ivan Santos Concepci\u00f3n (Predoctoral Researcher, The Canary Islands Health Research Institute Foundation, FIISC. Role of Alpha 2 adrenergic receptor subtypes in the acute and joint inflammatory response in vivo – \u00abPapel de los subtipos de receptores alpha2 adren\u00e9rgicos en la regulaci\u00f3n de la respuesta inflamatoria aguda y articular in vivo\u00bb).<\/li>\n<\/ul>\n

        TECHNICAL AND ADMINISTRATIVE STAFF:<\/h4>\n
          \n
        • Elsa Gonz\u00e1lez Oramas (Administrative, Project Manager, Predoctoral Researcher, FIISC)<\/li>\n<\/ul>\n

          RESEARCH LINES:<\/h4>\n
            \n
          • Role of free oxygen radicals in regulating first phase inflammatory responses.<\/li>\n
          • In vivo effect of anti-L-selectin substances in neutrophil migration.<\/li>\n
          • Modulation of the acute inflammatory response by the Alpha 2 adrenergic receptor.<\/li>\n
          • Role of B cell secreted soluble factors, cytokines and chemokines in the pathogenesis of rheumatoid arthritis.<\/li>\n
          • The capacity of resident pancreatic tissue stem cells to differentiate into adult endocrine pancreatic cells.<\/li>\n
          • Modulation of the acute and chronic inflammatory response by LXR receptors.<\/li>\n
          • Physical activity in patients with chronic joint diseases: a link between clinical activity and the capacity for movement.<\/li>\n<\/ul>\n

            FUNDED PROJECTS:<\/h4>\n
              \n
            • Role of Alpha 2 adrenergic receptor subtypes in the acute and joint inflammatory response in vivo (\u201cPapel de los subtipos de receptores alpha2 adren\u00e9rgicos en la regulaci\u00f3n de la respuesta inflamatoria aguda y articular in vivo\u201d). PI: Federico D\u00edaz. Institute of Health Carlos III (2016-2019, 90,000 \u20ac).<\/li>\n<\/ul>\n

              PUBLICATIONS 2019:<\/h4>\n
                \n
              • Sanchez-Piedra C,Hern\u00e1ndez Miguel MV,Manero J,Rosell\u00f3 R,S\u00e1nchez-Costa JT,Rodr\u00edguez-Lozano C,Campos C,Cuende E,Fern\u00e1ndez-Lopez JC,Bustabad S, Mart\u00edn Domenech R,P\u00e9rez-Pamp\u00edn E,Del Pino-Montes J,Millan-Arciniegas AM,D\u00edaz-Gonz\u00e1lez F,G\u00f3mez-Reino JJ; On behalf of the BIOBADASER Study Group. Objectives and methodology of BIOBADASER phase III [Objetivos y metodolog\u00eda de la fase III de BIOBADASER]. Reumatol Clin. 2019 Jul Aug;15(4):229-236. doi: 10.1016\/j.reuma.2017.08.001<\/li>\n
              • Ferraz-Amaro I,Hern\u00e1ndez-Hern\u00e1ndez MV,Tejera-Segura B,Delgado-Fr\u00edas E, Mac\u00eda-D\u00edaz M,Machado JD,Diaz-Gonz\u00e1lez F. Effect of IL-6 Receptor Blockade on Proprotein Convertase Subtilisin\/Kexin Type-9 and Cholesterol Efflux Capacity in Rheumatoid Arthritis Patients. Horm Metab Res. 2019 Mar;51(3):200-209. doi: 10.1055\/a-0833-4627<\/li>\n
              • Hernandez MV,Sanchez-Piedra C,Garcia-Magallon B,Cuende E,Manero J, Campos-Fernandez C,Martin-Domenech R,Del Pino-Montes J,Manrique S, Castro-Villegas MC,Ruiz-Montesinos D,Sanchez-Alonso F,Diaz-Gonzalez F,Cea-Calvo L,G\u00f3mez-Reino JJ;BIOBADASER Study Group.Factors associated with long- term retention of treatment with golimumab in a real-world setting: an analysis of the Spanish BIOBADASER registry. Rheumatol Int. 2019 Mar;39(3):509-515. doi: 10.1007\/s00296-018-4177-z<\/li>\n
              • Dom\u00ednguez-Luis MJ,Armas-Gonz\u00e1lez E,Herrera-Garc\u00eda A,Arce-Franco M,Feria M,Vicente-Manzanares M,Mart\u00ednez-Ruiz A,S\u00e1nchez-Madrid F,D\u00edaz-Gonz\u00e1lez F. L-selectin expression is regulated by CXCL8-induced reactive oxygen species produced during human neutrophil rolling. Eur J Immunol. 2019 Mar;49(3):386-397. doi: 10.1002\/eji.201847710<\/li>\n
              • L\u00f3pez-Isac E,Acosta-Herrera M,Kerick M, Assassi S, Satpathy AT,Granja J, Mumbach MR,Beretta L, Sime\u00f3n CP,Carreira P, Ortego-Centeno N,Castellvi I, Bossini-Castillo L,Carmona FD,Orozco G,Hunzelmann N,Distler JHW,Franke A, Lunardi C, Moroncini G,Gabrielli A,de Vries-Bouwstra J,Wijmenga C,KoelemanBPC, Nordin A,Padyukov L, Hoffmann-Vold AM,Lie B;European Scleroderma Group (Diaz-Gonzalez F). GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. Nat Commun. 2019 Oct 31;10(1):4955. doi: 10.1038\/s41467-019-12760-y<\/li>\n
              • Seoane-Mato D,S\u00e1nchez-Piedra C,Silva-Fern\u00e1ndez L,Sivera F,Blanco FJ, P\u00e9rezRuiz F,Juan-Mas A,Pego-Reigosa JM,Narv\u00e1ez J,Quilis Mart\u00ed N,Cort\u00e9s Verd\u00faR, Ant\u00f3n-Pag\u00e9s F,Quevedo Vila V,Garrido Courel L,Del Amo NDV,Paniagua Zudaire I,A\u00f1ez Sturchio G,Medina Varo F,Ruiz Tudela MDM,Romero P\u00e9rez A, Ballina J,Brandy Garc\u00eda A,F\u00e1bregas Canales D,Font Gay\u00e1 T,Bordoy Ferrer C, Gonz\u00e1lez \u00c1lvarez B,Casas Hern\u00e1ndez L,\u00c1lvarez Reyes F,Delgado S\u00e1nchez M,Mart\u00ednez Dubois C,S\u00e1nchez-Fern\u00e1ndez S\u00c1,Rojas Vargas LM,Garc\u00eda MoralesPV,Oliv\u00e9 A,Rubio Mu\u00f1oz P,Larrosa M,Navarro Ricos N, Graell Mart\u00edn E,Chamizo E, Chaves Chaparro L,Rojas Herrera S,Pons Dolset J,Polo Ostariz M\u00c1,Ruiz-Alejos Garrido S,Mac\u00eda Villa C, Cruz Valenciano A,Gonz\u00e1lez G\u00f3mez ML,Morcillo Valle M,Palma S\u00e1nchez D,Moreno Mart\u00ednez MJ,Mayor Gonz\u00e1lez M,Atxotegi S\u00e1enz deBuruaga J,Urionag\u00fcena Onaindia I,Blanco C\u00e1ceres BA,D\u00edaz-Gonz\u00e1lez F,Bustabad Prevalence of rheumatic diseases in adult population in Spain (EPISER 2016 study): Aims and methodology [Prevalencia de enfermedades reum\u00e1ticas en poblaci\u00f3n adulta en Espa\u00f1a (estudio EPISER 2016). Objetivos y metodolog\u00eda]. Reumatol Clin. 2019 Mar – Apr;15(2):90-96. doi: 10.1016\/j.reuma.2017.06.009<\/li>\n
              • Rodr\u00edguez-Lozano B,Gonz\u00e1lez-Febles J,Garnier-Rodr\u00edguez JL,Dadlani S,Bustabad-Reyes S,Sanz M,S\u00e1nchez-Alonso F,S\u00e1nchez-Piedra C,Gonz\u00e1lez-D\u00e1vila E,D\u00edaz-Gonz\u00e1lez F. Association between severity of periodontitis and clinical activity in rheumatoid arthritis patients: A case-control study. Arthritis Res Ther. 2019 Jan18;21(1):27. doi: 10.1186\/s13075-019-1808-z<\/li>\n
              • Rovin BH, Solomons N,Pendergraft WF 3rd,Dooley MA,Tumlin J,Romero-Diaz J, Lysenko L,Navarra SV,Huizinga RB;AURA-LV Study Group (Diaz-Gonzalez F). A randomized, controlled double-blind study comparing the efficacy and safety of dose-ranging voclosporin with placebo in achieving remission in patients with active lupus nephritis. Kidney Int. 2019 Jan;95(1):219-231. doi: 10.1016\/j.kint.2018.08.025<\/li>\n
              • Urruticoechea-Arana A, Cobo-Ib\u00e1\u00f1ez T,Villaverde-Garc\u00eda V,Santos G\u00f3mez M,Loza E, Vargas-Osorio K,Fari\u00f1as Padr\u00f3n L,Diaz-Gonzalez F,Calvo-R\u00edo V,Blanco R. Efficacy and safety of biological therapy compared to synthetic immunomodulatory drugs or placebo in the treatment of Beh\u00e7et\u2019s disease associated uveitis: a systematic review. Rheumatol Int. 2019 Jan;39(1):47-58. doi: 10.1007\/s00296-018-4193-z<\/li>\n
              • Abad Hern\u00e1ndez M\u00c1, Andreu JL, Balsa Criado A, D\u00edaz-Gonz\u00e1lez F, Moreno Muelas JV, Queiro Silva R, G\u00f3mez-Reino JJ. Update of the Position Paper of the Spanish Society of Rheumatology on Biosimilar Drugs. Reumatol Clin. 2019 May 1. pii: S1699-258X(19)30059-2. doi: 10.1016\/j.reuma.2019.03.007. [Epub ahead of print]<\/li>\n<\/ul>\n

                OTHER SELECTED PUBLICATIONS FROM THE LAST 10 YEARS:<\/h4>\n
                  \n
                • \u00c1lvaro-Gracia JM, Jover JA, Garc\u00eda-Vicu\u00f1a R, Carre\u00f1o L, Alonso A, Marsal S, Blanco F, Mart\u00ednez-Taboada VM, Taylor P, Mart\u00edn-Mart\u00edn C, DelaRosa O, Tagarro I, D\u00edaz-Gonz\u00e1lez F. Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis (Cx611): results of a multicentre, dose escalation, randomised, single-blind, placebo-controlled phase Ib\/IIa clinical trial. Ann Rheum Dis. 2017 Jan;76(1):196-202. doi:10.1136\/annrheumdis-2015-208918<\/li>\n
                • Cutolo M, Myerson GE, Fleischmann RM, Liote F, D\u00edaz-Gonz\u00e1lez F, Van den Bosch F, Mazo-Ortega H, Feist E, Shan K, Hu C, Stevens RM, Poder A. A phase III, randomized, controlled trial of Apremilast in patients with psoriatic arthritis: resilys of the PALACE 2 trial. JRheumatol. 2016 Sep;43(9):1724-34. doi:10.3899\/jrheum.151376<\/li>\n
                • Armas-Gonz\u00e1lez E, Diaz-Martin A, Dominguez-Luis MJ, Arce Franco MT, Herrero Garcia A, Hernandez-Hernandez MV, Bustabad S, Usategui A, Pablos JL, Canete JD, D\u00edaz-Gonz\u00e1lez F. Differential antigen-presenting B cell phenotypes from synovial microenvironment of patients with rheumatoid and psoriatic arthritis. J Rheumatol. 2015 Oct;42(10):1825-34. doi: 10.3899\/jrheum.141577<\/li>\n
                • Delgado-Frias E, Lopez-Mejias R, Genre F, Ubilla B, Gomez Rodriguez-Bethencourt MA, Gonz\u00e1lez-D\u00edaz A, de Vera-Gonzalez AM, Gonzalez-Rivero AF, Diaz-Gonzalez F, Gonzalez-Gay MA, Ferraz-Amato I. Relatioship between endothelial dysfunction and osteoprotegerin, vitamin D, and bone mineral density in patients with rheumatoid arthritis. Clin Exp Rheumatol. 2015 Mar-Apr;33(2):241-9<\/li>\n
                • Ferraz-Amaro I, Gonzalez-Gay MA, Diaz-Gonz\u00e1lez F. Retinol-binding Protein 4 in Rheumatoid Arthritis-related Insulin Resistance and \u03b2-cell Function. J Rheumatol. 2014 Apr;41(4):658-65. doi: 10.3899\/jrheum.130834<\/li>\n
                • Herrera-Garc\u00eda AM, Dom\u00ednguez-Luis MJ, Arce-Franco M, Armas-Gonz\u00e1lez E, \u00c1lvarez de La Rosa D, Machado JD, Pec MK, Feria M, Barreiro O, S\u00e1nchez-Madrid F, D\u00edaz-Gonz\u00e1lez F. Prevention of neutrophil extravasation by \u03b12-adrenoceptor-mediated endothelial stabilization. J Immunol. 2014 Sep 15;193(6):3023-35. doi:10.4049\/jimmunol.1400255<\/li>\n<\/ul>\n<\/div>\n
                  <\/div>\n

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                  [vc_row][vc_column][vc_column_text] Inflammatory response and tissue damage in rheumatoid arthritis PRINCIPAL INVESTIGATOR Jos\u00e9 Federico D\u00edaz Gonz\u00e1lez, MD, PhD Professor of Medicine, Department of Internal Medicine, Dermatology and Psychiatry, ULL \u2013 Head of Rheumatology Service, HUC POSTDOCTORAL CLINICAL COLLABORATORS: Judith M\u00aa L\u00f3pez Fern\u00e1ndez, MD, PhD (Attending Physician, Endocrinology Service, HUC) Iv\u00e1n Ferraz Amaro, MD, PhD (Attending Physician,…<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/template-no-title.php","meta":[],"_links":{"self":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages\/330"}],"collection":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/comments?post=330"}],"version-history":[{"count":1,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages\/330\/revisions"}],"predecessor-version":[{"id":331,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages\/330\/revisions\/331"}],"wp:attachment":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/media?parent=330"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}