{"id":335,"date":"2021-03-19T08:20:38","date_gmt":"2021-03-19T08:20:38","guid":{"rendered":"http:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/?page_id=335"},"modified":"2021-03-19T08:20:38","modified_gmt":"2021-03-19T08:20:38","slug":"mathematical-modelling-of-biological-systems-and-human-diseases","status":"publish","type":"page","link":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/mathematical-modelling-of-biological-systems-and-human-diseases\/","title":{"rendered":"Mathematical modelling of biological systems and human diseases"},"content":{"rendered":"

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Mathematical modelling of biological systems and human diseases<\/h1>\n<\/div>\n
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PRINCIPAL INVESTIGATOR<\/h4>\n\n\n\n
<\/td>\nN\u00e9stor Torres Darias, PhD<\/strong><\/p>\n

Professor of Biochemistry and Molecular Biology, Department of Biochemistry, Microbiology, Cellular Biology and Genetics, ULL<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

POSTDOCTORAL RESEARCHERS:<\/h4>\n
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  • Daniel V. Guebel, PhD (\u201cAgust\u00edn de Betancourt\u201d Researcher, Department of Biochemistry, Microbiology, Cellular Biology and Genetics, ULL)<\/li>\n
  • Carmen Laura Sayas Casanova \u201cAgust\u00edn de Betancourt\u201d Researcher, Department of Biochemistry, Microbiology, Cellular Biology and Genetics, ULL)<\/li>\n<\/ul>\n

    RESEARCH LINES:<\/h4>\n

    We use a combination of mathematical modelling, computational biology and machine learning techniques to tackle biomedical and biotechnological problems. So far, we have concentrated our efforts on identifying molecular targets for the treatment of infectious diseases (malaria, leishmania, AIDS), bioprocess optimisation and improvement (carnitine, terpenes), and more recently, in analysing the molecular basis in Alzheimer\u2019s disease. In this latter field, we are currently developing a technological transfer project to set up a reliable non-invasive method for early Alzheimer\u2019s diagnosis.<\/p>\n

    FUNDED PROJECTS:<\/h4>\n
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    • Identification of therapeutic targets and generation of neuroprotective peptides in Alzheimer\u2019s disease and related taupathies. Agust\u00edn de Betancourt Project (\u201cIdentificaci\u00f3n de nuevas dianas terap\u00e9uticas y generaci\u00f3n de nuevos p\u00e9ptidos neuroprotectores en la enfermedad de Alzheimer y tauopat\u00edas relacionadas\u201d). PI: Laura Sayas Casanova; Supervisor: N\u00e9stor Torres. Regional Government of Tenerife (2017-2021, 160,000 \u20ac.)<\/li>\n
    • Proof of concept for a non-invasive technology for early diagnosis of Sporadic Alzheimer’s Disease based on circulating exosomes in peripheral blood. Agust\u00edn de Betancourt Project (\u00abPrueba de concepto para una tecnolog\u00eda no-invasiva de diagn\u00f3stico temprano de Enfermedad de Alzheimer Espor\u00e1dica basada en exosomas circulantes en sangre perif\u00e9rica\u00bb) PI: Daniel V. Guebel; IP-ULL: N\u00e9stor Torres. Regional Government of Tenerife (granted in 2018, implementation 2019-2023, 160,000 \u20ac)<\/li>\n<\/ul>\n

      PUBLICATIONS 2019:<\/h4>\n
        \n
      • Dorta-Guerra R, Marrero I, Abdul-Jalbar B, Trujillo-Gonz\u00e1lez R, Torres NV. A new academic performance indicator for the first term of first-year science degrees students at La Laguna University: a predictive model. FEBS Open Bio. 2019 Sep;9(9):1493-1502. doi: 1002\/2211-5463.12707<\/li>\n
      • Sayas CL, Medina M, Cuadros R, Oll\u00e1 I, Garc\u00eda E, P\u00e9rez M, Ferrer I, Hern\u00e1ndez F, Avila J. Role of tau N-terminal motif in the secretion of human tau by End Binding proteins. PLoS One. 2019 Jan 22;14(1): e0210864. doi: 10.1371\/journal.pone.0210864<\/li>\n
      • Sayas CL, Basu S, van der Reijden M, Bustos-Mor\u00e1n E, Liz M, Sousa M, van IJcken WFJ, Avila J, Galjart N. Distinct Functions for Mammalian CLASP1 and -2 During Neurite and Axon Elongation. Front Cell Neurosci. 2019 Jan 29;13:5. doi: 10.3389\/fncel.2019.00005<\/li>\n
      • Gozes I, Ivashko-Pachima Y, Kapitansky O, Sayas CL, Iram T. Single-cell analysis of cytoskeleton dynamics: From isoelectric focusing to live cell imaging and RNA-seq. J Neurosci Methods. 2019 Jul 15;323: 119-124. doi: 10.1016\/j.jneumeth.2019.05.014<\/li>\n
      • Ivashko-Pachima Y, Hadar A, Grigg I, Korenkov\u00e1 V, Kapitansky O, Karmon G, Gershovits M, Sayas CL, Kooy RF, Attems J, Gurwitz D, Gozes I. Discovery of autism\/intellectual disability somatic mutations in Alzheimer\u2019s brains: mutated ADNP cytoskeletal impairments and repair as a case study. Mol Psychiatry. 2019 Oct 30. doi: 10.1038\/s41380-019-0563-5. [Epub ahead of print]<\/li>\n<\/ul>\n

        OTHER SELECTED PUBLICATIONS FROM THE LAST 10 YEARS:<\/h4>\n
          \n
        • Guebel DV, Torres NV. Sexual dimorphism and aging in the human hippocampus: Identification, validation and impact of differentially expressed genes by factorial microarray and network analysis. Front Aging Neurosci. 2016 Oct 5;8:229. doi: 10.3389\/fnagi.2016.00229<\/li>\n
        • Santos G, D\u00edaz M, Torres NV. Lipid Raft Size and Lipid Mobility in Non-raft Domains Increase during Aging and Are Exacerbated in APP\/PS1 Mice Model of. Predictions from an Agent-Based Mathematical Model. Front 2016 Mar 15;7:90. doi: 10.3389\/fphys.2016.00090<\/li>\n
        • Guebel DV, Perera-Aberto M, Torres NV. Q-GDEMAR: a general method for the identification of differentially expressed genes in microarrays with unbalanced groups. Mol Biosyst. 2016 Jan;12(1):120-32. doi: 10.1039\/c5mb00541h<\/li>\n
        • Santos G, Torres NV. New Targets for Drug Discovery against Malaria. PLoS ONE. 2013;8(3):e59968. doi: 10371\/journal.pone.00599968<\/li>\n
        • Santos G, Hormiga JA, Arense P, Canovas M, Torres NV. Modelling and analysis of central metabolism operating regulatory interactions in salt stress conditions in a L-carnitine overproducing E. coli strain. PLoS ONE. 2012;7(4):e34533. doi: 10.1371\/journal.pone.0034533<\/li>\n<\/ul>\n<\/div>\n
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          <\/div>\n<\/div>\n

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          [vc_row][vc_column][vc_column_text] Mathematical modelling of biological systems and human diseases PRINCIPAL INVESTIGATOR N\u00e9stor Torres Darias, PhD Professor of Biochemistry and Molecular Biology, Department of Biochemistry, Microbiology, Cellular Biology and Genetics, ULL POSTDOCTORAL RESEARCHERS: Daniel V. Guebel, PhD (\u201cAgust\u00edn de Betancourt\u201d Researcher, Department of Biochemistry, Microbiology, Cellular Biology and Genetics, ULL) Carmen Laura Sayas Casanova \u201cAgust\u00edn de…<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/template-no-title.php","meta":[],"_links":{"self":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages\/335"}],"collection":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/comments?post=335"}],"version-history":[{"count":1,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages\/335\/revisions"}],"predecessor-version":[{"id":336,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages\/335\/revisions\/336"}],"wp:attachment":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/media?parent=335"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}