{"id":337,"date":"2021-03-19T08:22:04","date_gmt":"2021-03-19T08:22:04","guid":{"rendered":"http:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/?page_id=337"},"modified":"2021-03-19T08:22:04","modified_gmt":"2021-03-19T08:22:04","slug":"biolab-phenotypic-drug-discovery","status":"publish","type":"page","link":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/biolab-phenotypic-drug-discovery\/","title":{"rendered":"BioLab (\u201cPhenotypic drug discovery\u201d)"},"content":{"rendered":"

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BioLab (\u201cPhenotypic drug discovery\u201d)<\/h1>\n<\/div>\n
\n

PRINCIPAL INVESTIGATOR<\/h4>\n\n\n\n
<\/td>\nJos\u00e9 Manuel Padr\u00f3n<\/strong><\/p>\n

University Lecturer; Department of Organic Chemistry, ULL<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

POSTDOCTORAL RESEARCHERS:<\/h4>\n
    \n
  • Miguel X. Fernandes (\u201cAgust\u00edn de Betancourt\u201d Researcher, ULL)<\/li>\n<\/ul>\n

    PHD STUDENTS AND TRAINEES:<\/h4>\n
      \n
    • Adri\u00e1n Puerta Arocha (Doctorate Program in Health Sciences, PGC2018-094503-B-C22, MCIU\/AEI\/FEDER, UE)<\/li>\n
    • Alexis Gal\u00e1n Rodr\u00edguez (Doctorate Program in Chemistry, PGC2018-094503-B-C22, MCIU\/AEI\/FEDER, UE)<\/li>\n
    • Amina Moutayakine (Doctorate Program in Chemistry, PGC2018-094503-B-C22, MCIU\/AEI\/FEDER, UE)<\/li>\n
    • Alicia Hern\u00e1ndez P\u00e9rez (Doctorate Program in Health Sciences, Doctorado Industrial, Orfan Biotech SL)<\/li>\n<\/ul>\n

      RESEARCH LINES:<\/h4>\n
        \n
      • Drug discovery: Early identification of the therapeutic targets of biologically active molecules. The identification of the biological targets with which the small molecules interact is determined based on phenotypic and in silico experimental data. Once the biological target has been predicted, the process to validate it goes through the confirmation of the activity of the compound on the proposed target. The next step involves studying the effect in live models, when the compound gains added value and the viability of its technology transfer is evaluated.<\/li>\n
      • Bioprospecting of marine and terrestrial resources. The search for new bioactive compounds from natural sources has been motivated by the increase in the worldwide incidence of various types of cancer and the emergence of pathogens resistant to the available antibiotics. Our institute participates in the bioprospecting of marine and terrestrial resources in our region, Latin America, Africa and Asia in order to access substances of interest to the pharmaceutical, cosmetic, food or veterinary industries.<\/li>\n
      • Design and synthesis of molecular probes. The fluorescent probes used in immunofluorescence techniques are usually antibodies. However, anchoring a fluorescent group to a small molecule by derivatisation facilitates cell localization studies. Based on the results of structure-function studies, we can define the site in the reference molecule where a fluorescent fragment can be introduced.<\/li>\n<\/ul>\n

        FUNDED PROJECTS:<\/h4>\n
          \n
        • Preparation of the MSC-ITN action \u201cMultitargeted therapies against pancreatic ductal adenocarcinoma (PANCNET, EIN2019-102928) PI: Jos\u00e9 M. Padr\u00f3n (01\/06\/2019 to 31\/05\/2021, 16,200 \u20ac).<\/li>\n
        • Inhibition of glutamine metabolism as therapy against pancreatic ductal adenocarcinoma (\u00abInhibici\u00f3n del metabolismo de la glutamina como terapia contra el adenocarcinoma ductal pancre\u00e1tico. \u00abAgust\u00edn de Betancourt\u00bb) project. PI: Miguel X. Fernandes; IP-ULL: Jos\u00e9 M. Padr\u00f3n. Regional Government of Tenerife (2018-2022, 160,000 \u20ac).<\/li>\n<\/ul>\n

          PUBLICACTIONS 2019:<\/h4>\n
            \n
          • Filipovi\u0107 NR, Risti\u0107 P, Janji\u0107 G, Klisuric O, Padron JM, Donnard M, Gulea M, Todorovi\u0107 TR. Silver-based monomer and coordination polymer with organic thiocyanate ligand: Structural, computational and antiproliferative activity study. 2019 Polyhedron 173,114132 doi: 10.1016\/j.poly.2019.114132<\/li>\n
          • S\u00e1nchez-Fern\u00e1ndez EM, Garc\u00eda-Moreno MI, Arroba AI, Aguilar-Diosdado M, Padr\u00f3n JM, Garc\u00eda-Hern\u00e1ndez R, Gamarro F, Fustero S, S\u00e1nchez-Aparicio J-E, Masgrau L, Garc\u00eda Fern\u00e1ndez JM, Ortiz Mellet C. Synthesis of polyfluoroalkyl SP2-iminosugar glycolipids and evaluation of their immunomodulatory properties towards anti-tumor, anti-leishmanial and anti-inflammatory therapies. 2019 European Journal of Medicinal Chemistry 182,111604. doi: 10.1016\/j.ejmech.2019.111604<\/li>\n
          • Rold\u00e1n-Pe\u00f1a JM,Romero-Real V,Hicke J,Maya I,Franconetti A,Lagunes I,Padr\u00f3nJM, Petralla S,Poeta E,Naldi M,Bartolini M,Monti B,Bolognesi ML,L\u00f3pez \u00d3,Fern\u00e1ndez-Bola\u00f1os JG.Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer\u2019s disease: Selective subnanomolar BuChE inhibitors. 2019 Eur J Med Chem. 2019 Nov 1;181:111550. doi: 10.1016\/j.ejmech.2019.07.053<\/li>\n
          • Cort\u00e9s-Percino A,Vega-B\u00e1ez JL,Romero-L\u00f3pez A,Puerta A,Merino-Montiel P,Meza-Reyes S,Padr\u00f3n JM, Montiel-Smith S. Synthesis and evaluation of pyrimidine steroids as antiproliferative agents. 2019 Oct 12;24(20). pii: E3676. doi: 10.3390\/molecules24203676<\/li>\n
          • Ingold M,Colella L,Hern\u00e1ndez P,Batthy\u00e1ny C,Tejedor D,Puerta A,Garc\u00eda-Tellado F, Padr\u00f3n JM,Porcal W,L\u00f3pez GV.A Focused Library of NO-Donor Compounds with Potent Antiproliferative Activity Based on Green Multicomponent Reactions. 2019 Sep 18;14(18):1669-1683. doi: 10.1002\/cmdc.201900385<\/li>\n
          • S\u00e1nchez-Fern\u00e1ndez EM,Garc\u00eda-Moreno MI,Garc\u00eda-Hern\u00e1ndez R,Padr\u00f3nJM,Garc\u00eda Fern\u00e1ndez JM,Gamarro F,Ortiz Mellet C. Thiol-ene \u201cclick\u201d synthesis and pharmacological evaluation of C-glycoside SP2-iminosugar glycolipids. 2019 Aug 8;24(16). pii: E2882. doi: 10.3390\/molecules24162882<\/li>\n
          • S\u00e1nchez-Tafolla L, Padr\u00f3n JM, Mendoza G, Luna-Rodr\u00edguez M, Fern\u00e1ndez JJ, Norte M, Trigos \u00c1. Antiproliferative activity of biomass extract from Pseudomonas cedrina. 2019 Electronic Journal of Biotechnology 40, pp. 40-44. doi: 10.1016\/j.ejbt.2019.03.010<\/li>\n
          • Castillo QA, Padr\u00f3n JM, Wojtas L, Keramane M, Germos\u00e9n EA. Koanolide A, antiproliferative germacrane-type sesquiterpene lactone from Koanophyllon gibbosum. 2019 Tetrahedron Letters 60(25), pp. 1640-1642. doi: 10.1016\/j.tetlet.2019.05.036<\/li>\n
          • Luque-Agudo V,Albarr\u00e1n-Velo J,Light ME,Padr\u00f3n JM,Rom\u00e1n E,Serrano JA, Gil Synthesis and antiproliferative activity of new 2-glyco-3-nitro-2H-chromenes. Bioorg Chem. 2019 Jun;87:112-116. doi: 10.1016\/j.bioorg.2019.03.016<\/li>\n
          • Castro SJ,Casero CN,Padr\u00f3n JM,Nicotra VE.Selective Antiproliferative Withanolides from Species in the Genera Eriolarynx and Deprea. J Nat 2019 May 24;82(5):1338-1344. doi: 10.1021\/acs.jnatprod.9b00117<\/li>\n
          • Patel DM,Sharma MG,Vala RM,Lagunes I,Puerta A,Padr\u00f3n JM,Rajani DP,PatelHydroxyl alkyl ammonium ionic liquid assisted green and one-pot regioselective access to functionalized pyrazolodihydropyridine core and their pharmacological evaluation. Bioorg Chem. 2019 May;86:137-150. doi: 10.1016\/j.bioorg.2019.01.029<\/li>\n
          • Hamuli\u0107 D,Stadler M,Hering S,Padr\u00f3n JM,Bassett R,Rivas F,Loza-Mej\u00eda MA, Dea-Ayuela MA,Gonz\u00e1lez-Cardenete MA.Synthesis and Biological Studies of (+)-Liquiditerpenoic Acid A (Abietopinoic Acid) and Representative Analogues: SAR Stud J Nat Prod. 2019 Apr 26;82(4):823-831. doi: 10.1021\/acs.jnatprod.8b00884<\/li>\n
          • Beer MF,Bivona AE,S\u00e1nchez Alberti A,Cerny N,Reta GF,Mart\u00edn VS,Padr\u00f3nJM, Malchiodi EL,S\u00fclsen VP,Donadel OJ.Preparation of sesquiterpene lactone derivatives: Cytotoxic activity and selectivity of action. 2019 Mar 20;24(6). pii: E1113. doi: 10.3390\/molecules24061113<\/li>\n
          • Padr\u00f3n JM, Emiliano A, Castillo QA. Secondary Metabolites from Pterocaulon alopecuroides and their Antiproliferative Activities. 2019 Pharmacognosy Journal 11(3), pp. 493-495. doi: 10.5530\/pj.2019.11.78<\/li>\n
          • Franceschy C,Espinoza C, Padr\u00f3n JM,Landa-Cadena G,Norte M,Fern\u00e1ndez JJ, Shnyreva A,Trigos \u00c1. Antiproliferative potential of 3\u03b2,5\u03b1,6\u03b2,7\u03b1- tetrahydroxyergosta-8(14),22-diene produced by Acremonium persicinum isolated from an alkaline crater lake in Puebla, Mexico. Nat Prod Res. 2019 Sep 26:1-4. doi: 10.1080\/14786419.2019.1669032. [Epub ahead of print]<\/li>\n
          • Brahmbhatt GC,Sutariya TR,Atara HD,Parmar NJ,Gupta VK,Lagunes I,Padr\u00f3nJM, Murumkar PR,Yadav MR. New pyrazolyl-dibenzo[b,e][1,4]diazepinones: room temperature one-pot synthesis and biological evaluation. Mol Divers. 2019 May 24. doi: 10.1007\/s11030-019-09958-z. [Epub ahead of print]<\/li>\n
          • Lagunes I, Begines P, Silva A, Gal\u00e1n AR, Puerta A, Fernandes MX, Maya I, Fern\u00e1ndez-Bola\u00f1os JG, L\u00f3pez \u00d3, Padr\u00f3n JM. Selenocoumarins as new multitarget antiproliferative agents: Synthesis, biological evaluation and in silico calculations. Eur J Med Chem. 2019 Oct 1;179:493-501. doi: 10.1016\/j.ejmech.2019.06.073<\/li>\n
          • Dini\u0107 J, R\u00edos-Luci C, Karpaviciene I, Cikotiene I, Fernandes MX, Pe\u0161i\u0107 M, Padr\u00f3n JM. CKT0353, a novel microtubule targeting agent, overcomes paclitaxel induced resistance in cancer cells. Invest New Drugs. 2019 Jun 8. doi: 10.1007\/s10637-019- 00803-6. [Epub ahead of print]<\/li>\n
          • Rodriguez-Rodriguez AE, Donate-Correa J, Rovira J, Cuesto G, Luis-Ravelo D, Fernandes MX, Acevedo-Arozena A, Diekmann F, Acebes A, Torres A, Porrini E. Inhibition of the mTOR pathway: A new mechanism of \u03b2 cell toxicity induced by Tacrolimu Am J Transplant. 2019 Dec;19(12):3240-3249. doi: 10.1111\/ajt.15483<\/li>\n
          • Serina J, Fernandes MX, Castilho PC. Effects of hydroxycinnamic acids on the glycolysis pathway. 2019 South African Journal of Botany 120, pp. 219-229. doi: 10.1016\/j.sajb.2018.06.016<\/li>\n
          • Other selected publications from the last 10 years:<\/li>\n
          • Podolski-Reni\u0107 A,Bankovi\u0107 J,Dini\u0107 J,R\u00edos-Luci C,Fernandes MX,OrtegaN,Kova\u010devi\u0107-Gruji\u010di\u0107 N, Mart\u00edn VS,Padr\u00f3n JM, Pe\u0161i\u0107 M. DTA0100, dual topoisomerase II and microtubule inhibitor, evades paclitaxel resistance in P- glycoprotein overexpressing cancer cells. Eur J Pharm Sci. 2017 Jul 15;105:159-168. doi: 10.1016\/j.ejps.2017.05.011<\/li>\n
          • Silveira-Dorta G, Sousa IJ, Fernandes MX, Mart\u00edn VS, Padr\u00f3n JM. Synthesis and identification of unprecedented selective inhibitors of CK1\u03b5. Eur J Med 2015;96:308-17. doi: 10.1016\/j.ejmech.2015.03.046<\/li>\n
          • Silveira-Dorta G, Mart\u00edn VS, Padr\u00f3n JM. Synthesis and antiproliferative activity of glutamic acid-based dipeptides. Amino Acids. 2015 Aug;47(8):1527-32. doi: 10.1007\/s00726-015-1987-0<\/li>\n<\/ul>\n<\/div>\n
            <\/div>\n

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            [vc_row][vc_column][vc_column_text] BioLab (\u201cPhenotypic drug discovery\u201d) PRINCIPAL INVESTIGATOR Jos\u00e9 Manuel Padr\u00f3n University Lecturer; Department of Organic Chemistry, ULL POSTDOCTORAL RESEARCHERS: Miguel X. Fernandes (\u201cAgust\u00edn de Betancourt\u201d Researcher, ULL) PHD STUDENTS AND TRAINEES: Adri\u00e1n Puerta Arocha (Doctorate Program in Health Sciences, PGC2018-094503-B-C22, MCIU\/AEI\/FEDER, UE) Alexis Gal\u00e1n Rodr\u00edguez (Doctorate Program in Chemistry, PGC2018-094503-B-C22, MCIU\/AEI\/FEDER, UE) Amina Moutayakine (Doctorate…<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/template-no-title.php","meta":[],"_links":{"self":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages\/337"}],"collection":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/comments?post=337"}],"version-history":[{"count":1,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages\/337\/revisions"}],"predecessor-version":[{"id":338,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages\/337\/revisions\/338"}],"wp:attachment":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/media?parent=337"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}