{"id":341,"date":"2021-03-19T08:24:50","date_gmt":"2021-03-19T08:24:50","guid":{"rendered":"http:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/?page_id=341"},"modified":"2021-03-19T08:24:50","modified_gmt":"2021-03-19T08:24:50","slug":"molecular-mechanisms-in-neurodegeneration","status":"publish","type":"page","link":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/molecular-mechanisms-in-neurodegeneration\/","title":{"rendered":"Molecular mechanisms in neurodegeneration"},"content":{"rendered":"

[vc_row][vc_column][vc_column_text]<\/p>\n

\n

\u00a0Molecular mechanisms in neurodegeneration<\/h1>\n<\/div>\n
\n

PRINCIPAL INVESTIGATOR<\/h4>\n\n\n\n
<\/td>\n\u00c1ngel Acebes Vindel, PhD<\/strong><\/p>\n

Contracted Lecturer, Doctor in Physiology, Department of Basic Medical Sciences, ULL<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

POSTDOCTORAL RESEARCHERS:<\/h4>\n
    \n
  • Elena Quintana, PhD ACIISI (Postdoctoral Researcher, The Canary Islands Agency for Research, Innovation and Information Sciences, ACIISI, ProID2017010101, ULL)<\/li>\n
  • Carlos Cair\u00f3s, PhD (\u00abAgust\u00edn de Betancourt\u00bb Researcher; Department of Basic Medical Sciences, ULL, ULL, since January 2020).<\/li>\n<\/ul>\n

    PHD STUDENTS AND TRAINEES:<\/h4>\n
      \n
    • Ninovska Romero Luis (Health Sciences Doctoral Programme, contracted by Project ProID2017010101, until July 2019)<\/li>\n<\/ul>\n

      RESEARCH LINES:<\/h4>\n

      Using genetic and molecular tools in Drosophila melanogaster and transgenic mouse models, we analyse the effect of increasing the number of synapses in vivo in animal models during the early onset of Alzheimer’s disease (AD), characterized by the extensive loss of Synaptic Connections. In both animal models, overexpression of the phosphoinositide-3-kinase (PI3K) synaptogenic tool will take place early in the development to increase the number of synapses, and to restore sensory and neuronal deficits generated after genetically and pharmacologically induced neurodegeneration. Our main goal is to identify and validate pro-synaptic tools with the potential to be used as therapies in human neurodegenerative diseases.<\/p>\n

      FUNDED PROJECTS:<\/h4>\n
        \n
      • A novel genetic, molecular and cellular approach to combat Alzheimer\u2019s disease. (ProID2017010101 – \u201cEnfermedad de Alzheimer: hacia un nuevo abordaje gen\u00e9tico, molecular y celular\u201d). PI: \u00c1ngel Acebes. The Canary Islands Agency of Research, Innovation and Information Sciences (2017-2020, 70,000 \u20ac).<\/li>\n
      • Laboratory intership abroad during the practical education of biological-technical Assistants (2019-1-DE02-KA102-005946). Spanish Coordinator: \u00c1ngel Acebes. Erasmus + European Union Programme (2019-2021, 212,999 \u20ac).<\/li>\n
      • Spanish Olfactory Network (\u00abRed olfativa espa\u00f1ola\u00bb – RED2018-102662-T). Aid to promote dynamization actions \u00abResearch networks\u00bb (\u00abAyudas para las acciones de dinamizaci\u00f3n \u201cRedes de investigaci\u00f3n\u201d). Co-PI: \u00c1ngel Acebes; MICINN (2020-2021, 17,000 \u20ac).<\/li>\n
      • MICROFAVAR: Development of a high-resolution, high-speed quantitative phase-contrast microscope for 3D imaging of biological samples (\u00abDesarrollo de un microscopio de contraste de fase cuantitativa de alta resoluci\u00f3n y alta velocidad para la obtenci\u00f3n de im\u00e1genes en 3D de muestras biol\u00f3gicas\u00bb). \u00abAgust\u00edn de Betancourt\u00bb project. PI: Carlos Cair\u00f3s; PI-ULL: \u00c1ngel Acebes. Regional Government of Tenerife (2020-2024, 160,000 \u20ac).<\/li>\n<\/ul>\n

        PUBLICATIONS 2019:<\/h4>\n
          \n
        • Rodriguez-Rodriguez AE, Donate-Correa J, Rovira J, Cuesto G, Luis-Ravelo D, Fernandes MX, Acevedo-Arozena A, Diekmann F, Acebes A, Torres A, Porrini E. Inhibition of the mTOR pathway: A new mechanism of \u03b2 cell toxicity induced by Tacrolimu Am J Transplant. 2019 Dec;19(12):3240-3249. doi: 10.1111\/ajt.15483<\/li>\n
        • Lahoz F, Acebes A, Gonz\u00e1lez-Hern\u00e1ndez T, de Armas-Rillo S, Soler-Carracedo K, Cuesto G, Mesa-Infante V. Random lasing in brain tissues. Organic Electronics. 2019 Dec;75, Article number 105389. doi: 1016\/j.orgel.2019.105389<\/li>\n<\/ul>\n

          OTHER SELECTED PUBLICATIONS FROM THE LAST 10 YEARS:<\/h4>\n
            \n
          • Jord\u00e1n-\u00c1lvarez S, Santana E, Casas-Tint\u00f3 S, Acebes A, Ferr\u00fas A. The equilibrium between antagonistic signaling pathways determines the number of synapses in Drosophila. PLoS One. 2017 Sep 11;12(9):e0184238. doi:10.1371\/journal.pone.0184238<\/li>\n
          • Tri\u00f1anes J, Rodriguez-Rodriguez A, Brito-Casillas Y, Wagner A, De Vries APJ, Cuesto G, Acebes A, Salido E, Torres A, Porrini E. Deciphering tacrolimus-induced toxicity in pancreatic \u03b2-cells. Am J Transplant. 2017 Nov;17(11):2829-2840. doi:10.1111\/ajt.14323<\/li>\n
          • Acebes A. Brain mapping and synapse quantification in vivo: It\u2019s time to imaging. Front Neuroanat. 2017 Mar 7;11:17. doi: 10.3389\/fnana.2017.00017<\/li>\n
          • Cuesto G, Jord\u00e1n-\u00c1lvarez S, Enriquez-Barreto L, Ferrus A, Morales M, Acebes A. GSK3\u03b2 inhibition promotes synaptogenesis in Drosophila and mammalian neurons. PLoS One. 2015 Mar 12;10(3):e0118475. doi: 10.1371\/journal.pone.0118475<\/li>\n
          • Acebes A, Devaud JM, Arnes M, Ferrus A. Central adaptation to odorants depends on PI3K levels in local interneurons of the antennal lobe. J Neurosci. 2012 Jan 11;32(2):417-22. doi: 10.1523\/JNEUROSCI.2921-11.2012<\/li>\n
          • Cuesto G,Enriquez-Barreto L,Caram\u00e9s C,Cantarero M,Gasull X,Sandi C,Ferr\u00fas A, Acebes A,Morales M. PI3K activation controls synaptogenesis and spinogenesis in hippocampal neurons. J Neurosci. 2011 Feb 23;31(8):2721-33. doi: 10.1523\/JNEUROSCI.4477-10.2011<\/li>\n<\/ul>\n<\/div>\n
            <\/div>\n

            [\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"

            [vc_row][vc_column][vc_column_text] \u00a0Molecular mechanisms in neurodegeneration PRINCIPAL INVESTIGATOR \u00c1ngel Acebes Vindel, PhD Contracted Lecturer, Doctor in Physiology, Department of Basic Medical Sciences, ULL POSTDOCTORAL RESEARCHERS: Elena Quintana, PhD ACIISI (Postdoctoral Researcher, The Canary Islands Agency for Research, Innovation and Information Sciences, ACIISI, ProID2017010101, ULL) Carlos Cair\u00f3s, PhD (\u00abAgust\u00edn de Betancourt\u00bb Researcher; Department of Basic Medical Sciences,…<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/template-no-title.php","meta":[],"_links":{"self":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages\/341"}],"collection":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/comments?post=341"}],"version-history":[{"count":1,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages\/341\/revisions"}],"predecessor-version":[{"id":342,"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/pages\/341\/revisions\/342"}],"wp:attachment":[{"href":"https:\/\/www.ull.es\/institutos\/institute-biomedical-technologies\/wp-json\/wp\/v2\/media?parent=341"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}