{"id":267,"date":"2021-03-11T11:39:28","date_gmt":"2021-03-11T11:39:28","guid":{"rendered":"http:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/?page_id=267"},"modified":"2026-07-08T12:17:25","modified_gmt":"2026-07-08T12:17:25","slug":"investigacion-en-enfermedad-renal-y-cardiovascular","status":"publish","type":"page","link":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/investigacion-en-enfermedad-renal-y-cardiovascular\/","title":{"rendered":"Research in kidney and cardiovascular disease"},"content":{"rendered":"<div class=\"wp-block-stackable-columns alignfull stk-block-columns stk-block stk-49c10bb stk-block-background stk--has-background-overlay\" data-block-id=\"49c10bb\"><style>.stk-49c10bb {background-color:linear-gradient(135deg,rgb(161,9,157) 1%,rgb(63,37,132) 100%) !important;margin-top:-3% !important;margin-bottom:3% !important;}.stk-49c10bb:before{background-image:linear-gradient(135deg,rgb(161,9,157) 1%,rgb(63,37,132) 100%) !important;}.stk-49c10bb-column{justify-content:center !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-49c10bb-column stk--flex alignfull\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-429e70e\" data-v=\"4\" data-block-id=\"429e70e\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-429e70e-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-429e70e-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-616317e\" id=\"investigacion-en-enfermedad-renal-y-cardiovascular\" data-block-id=\"616317e\"><style>.stk-616317e {align-items:center !important;display:flex !important;}.stk-616317e .stk-block-heading__text{color:#ffffff !important;font-weight:800 !important;}<\/style><h2 class=\"stk-block-heading__text has-text-color has-text-align-center\">Research in kidney and cardiovascular disease<\/h2><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-8b59b96\" data-block-id=\"8b59b96\"><style>.stk-8b59b96 .stk--block-align-8b59b96{align-items:flex-start !important;}.stk-8b59b96 {margin-top:25px !important;}.stk-8b59b96-column{--stk-columns-spacing:0px !important;--stk-column-gap:50px !important;}@media screen and (max-width: 767px){.stk-8b59b96-column{row-gap:var(--stk--preset--spacing--60, 2.25rem) !important;}}<\/style><div class=\"stk-row stk-inner-blocks stk--block-align-8b59b96 stk-block-content stk-content-align stk-8b59b96-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-dbb7e15\" data-v=\"4\" data-block-id=\"dbb7e15\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-dbb7e15-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-dbb7e15-inner-blocks\">\n<h4 class=\"wp-block-heading\"><strong>Principal Investigator<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><a href=\"https:\/\/portalciencia.ull.es\/investigadores\/205540\/detalle\" target=\"_blank\" rel=\"noreferrer noopener\">Juan Francisco Navarro Gonz\u00e1lez<\/a>, MD, PhD<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Head of Service of the Research Unit, HUNSC<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Collaborating researchers (PhDs)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>V\u00edctor Garc\u00eda Tagua, PhD (Assistant Professor; Department of Obstetrics and Gynecology, Pediatrics, Preventive Medicine and Public Health, Toxicology, Legal and Forensic Medicine and Parasitology, ULL) ?\u00a0<a href=\"https:\/\/portalciencia.ull.es\/investigadores\/82552\/detalle\" target=\"_blank\" rel=\"noreferrer noopener\">Link to ULL Science Portal<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>External collaborators and associated researchers<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Carmen Mora Fern\u00e1ndez (FEA Responsible for scientific management and innovation, HUNSC Research Unit)<\/li>\n\n\n\n<li>Desir\u00e9e Luis Rodr\u00edguez (FEA Nephrology Service, HUNSC)<\/li>\n\n\n\n<li>Victoria Castro L\u00f3pez-Tarruella (FEA Pathology Service, HUNSC)<\/li>\n\n\n\n<li>Orlando Siverio Morales (FEA Nephrology Service, HUNSC)<\/li>\n\n\n\n<li>Rosa P\u00e9rez Morales (FEA Nephrology Service, HUNSC)<\/li>\n\n\n\n<li>Carlos Mar\u00edn Delgado (FEA Nephrology Service, HUNSC)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>PhD students and researchers in training<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Carla Mar\u00eda Ferri (Doctoral Program in Health Sciences ULL, Canary Agency for Innovation, Research and Information Society, ACIISI, TESIS2018010110)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Technical or management staff<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Lisset Gonz\u00e1lez Burgos (Senior Technician, contracted for project RD21\/0005\/0013, ISCIII, HUNSC)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Lines of research<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Chronic kidney disease and its complications.<\/li>\n\n\n\n<li>Diabetic kidney disease.<\/li>\n\n\n\n<li>Implications of the inflammatory phenomenon in highly prevalent diseases.<\/li>\n\n\n\n<li>FGF23\/Klotho system.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Funded projects<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>FGF23\/Klotho system in subclinical atherosclerotic vascular disease. Pathophysiological implications and therapeutic approach (PI19\/00035). PI: Juan F. Navarro. Carlos III Health Institute (2020-2023, \u20ac56,870)<\/li>\n\n\n\n<li>RED RICORS2040 (KIDNEY DISEASE). RD21\/0005\/0013. IP: Juan F. Navarro. Carlos III Health Institute (2022-2024, \u20ac105,765)<\/li>\n\n\n\n<li>Detection of the Klotho protein using nanoantibodies obtained from Canary camelids (PIFIISC21\/23). PIs: Carmen Mora Fern\u00e1ndez and V\u00edctor Garc\u00eda Tagua. Canary Islands Foundation Institute of Health Research of the Canary Islands, FIISC (2022-2023, \u20ac27,000)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Publications 2023<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Donate-Correa J<\/strong>, Mart\u00edn-N\u00fa\u00f1ez E, Mora-Fern\u00e1ndez C, Gonz\u00e1lez-Luis A, Mart\u00edn-Olivera A,\u00a0<strong>Navarro-Gonz\u00e1lez JF<\/strong>. Association of Klotho with Coronary Artery Disease in Subjects with Type 2 Diabetes Mellitus and Preserved Kidney Function: A Case-Control Study.\u00a0<em>International Journal of Molecular Sciences<\/em>. 2023 Aug 30;24(17):13456. DOI: 10.3390\/ijms241713456<\/li>\n\n\n\n<li><strong>Donate-Correa J<\/strong>, Mart\u00edn-N\u00fa\u00f1ez E, Mora-Fern\u00e1ndez C, Gonz\u00e1lez-Luis A, Mart\u00edn-Olivera A,\u00a0<strong>Navarro-Gonz\u00e1lez JF<\/strong>. Associations between Inflammation, Hemoglobin Levels, and Coronary Artery Disease in Non-Albuminuric Subjects with and without Type 2 Diabetes Mellitus.\u00a0<em>International Journal of Molecular Sciences<\/em>. 2023;24(18). 2023 Sep 15;24(18):14131. DOI: 10.3390\/ijms241814131<\/li>\n\n\n\n<li>Mart\u00edn-Carro B,\u00a0<strong>Donate-Correa J<\/strong>, Fern\u00e1ndez-Villabrille S, Mart\u00edn-V\u00edrgala J, Panizo S, Carrillo-L\u00f3pez N, Mart\u00ednez-Arias L,\u00a0<strong>Navarro-Gonz\u00e1lez JF<\/strong>, Naves-D\u00edaz M, Fern\u00e1ndez-Mart\u00edn JL, Alonso-Montes C, Cannata-And\u00eda JB. Experimental Models to Study Diabetes Mellitus and Its Complications: Limitations and New Opportunities.\u00a0<em>International Journal of Molecular Sciences<\/em>. 2023 Jun 18;24(12):10309. DOI: 10.3390\/ijms241210309<\/li>\n\n\n\n<li><strong>Donate-Correa J<\/strong>, Mart\u00edn-N\u00fa\u00f1ez E, Martin-Olivera A, Mora-Fern\u00e1ndez C,\u00a0<strong>Tagua VG<\/strong>, Ferri CM, L\u00f3pez-Castillo \u00c1, Delgado-Molinos A, L\u00f3pez-Tarruella VC, Ar\u00e9valo-G\u00f3mez MA, P\u00e9rez-Delgado N, Gonz\u00e1lez-Luis A,\u00a0<strong>Navarro-Gonz\u00e1lez JF<\/strong>. Klotho inversely relates with carotid intima-media thickness in atherosclerotic patients with normal renal function (eGFR \u226560 mL\/min\/1.73m2): a proof-of-concept study.\u00a0<em>Frontiers in Endocrinology<\/em>. 2023;14:1146012. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.3389%2Ffendo.2023.1146012\" target=\"_blank\" rel=\"noreferrer noopener\">10.3389\/fendo.2023.1146012<\/a><\/li>\n\n\n\n<li><strong>Donate-Correa J<\/strong>, Mart\u00edn-Carro B, Cannata-And\u00eda JB, Mora-Fern\u00e1ndez C,\u00a0<strong>Navarro-Gonz\u00e1lez JF<\/strong>. Klotho, Oxidative Stress, and Mitochondrial Damage in Kidney Disease.\u00a0<em>Antioxidants<\/em>. 2023 Jan 20;12(2):239. DOI: 10.3390\/antiox12020239<\/li>\n\n\n\n<li>Mart\u00edn-Carro B, Mart\u00edn-V\u00edrgala J, Fern\u00e1ndez-Villabrille S, Fern\u00e1ndez-Fern\u00e1ndez A, P\u00e9rez-Basterrechea M,\u00a0<strong>Navarro-Gonz\u00e1lez JF<\/strong>,\u00a0<strong>Donate-Correa J<\/strong>, Mora-Fern\u00e1ndez C, Dusso AS, Carrillo-L\u00f3pez, N, Panizo S, Naves-D\u00edaz M, Fern\u00e1ndez-Mart\u00edn JL, Cannata-And\u00eda JB, Alonso-Montes C. Role of Klotho and AGE\/RAGE-Wnt\/\u03b2-Catenin Signaling Pathway on the Development of Cardiac and Renal Fibrosis in Diabetes.\u00a0<em>International Journal of Molecular Sciences<\/em>. 2023;24(6). DOI: 10.3390\/IJMS24065241<\/li>\n\n\n\n<li>Rayego-Mateos S, Rodrigues-Diez RR, Fernandez-Fernandez B, Mora-Fern\u00e1ndez C, Marchant V,\u00a0<strong>Donate-Correa J<\/strong>,\u00a0<strong>Navarro-Gonz\u00e1lez JF<\/strong>, Ortiz A, Ruiz-Ortega M. Targeting inflammation to treat diabetic kidney disease: the road to 2030.\u00a0<em>Kidney International<\/em>. 2023;103(2):282-96. DOI: 10.1016\/J.KINT.2022.10.030<\/li>\n\n\n\n<li><strong>Donate-Correa J<\/strong>, Matos-Perdomo E, Gonz\u00e1lez-Luis A, Mart\u00edn-Olivera A, Ortiz A, Mora-Fern\u00e1ndez C,\u00a0<strong>Navarro-Gonz\u00e1lez JF<\/strong>. The Value of Klotho in Kidney Transplantation.\u00a0<em>Transplantation<\/em>. 2023;107(3):616-27. DOI: 10.1097\/TP.0000000000004331<\/li>\n\n\n\n<li>Quiroga B, Ortiz A,\u00a0<strong>Navarro-Gonz\u00e1lez JF<\/strong>, Santamar\u00eda R, de Sequera P, D\u00edez J. From cardiorenal syndromes to cardionephrology: a reflection by nephrologists on renocardiac syndromes.\u00a0<em>Clin Kidney J<\/em>. 2023,16:19-29. DOI: 10.1093\/ckj\/sfac113<\/li>\n\n\n\n<li>Ortiz A, del Arco Gal\u00e1n C, Fern\u00e1ndez-Garc\u00eda JC, G\u00f3mez Cerezo J, Ib\u00e1n Ochoa R, N\u00fa\u00f1ez J, Pita Guti\u00e9rrez F,\u00a0<strong>Navarro Gonz\u00e1lez JF<\/strong>. Consensus document on the management of hyperkalemia.\u00a0<em>Nephrology<\/em>. 2023;43(5):765-782. DOI: 10.1016\/j.nefro.2023.05.004<\/li>\n\n\n\n<li>Mora-Fern\u00e1ndez C, P\u00e9rez A, Mollar A, Palau P, Amiguet M, de la Espriella R, Sanch\u00eds J, G\u00f3rriz JL, Soler MJ,\u00a0<strong>Navarro-Gonz\u00e1lez JF<\/strong>, N\u00fa\u00f1ez J. Short-term changes in Klotho and FGF23 in heart failure with reduced ejection fraction \u2013a substudy of the DAPA-VO2 study.\u00a0<em>Front Cardiovasc Med<\/em>. 2023;10:1242108. DOI: 10.3389\/fcvm.2023.1242108<\/li>\n\n\n\n<li>Mart\u00edn-Carro B,\u00a0<strong>Navarro-Gonz\u00e1lez JF<\/strong>, Ortiz A, Zoccalli C, Floege J, Ferreira MA, G\u00f3rriz-Teruel JL, Carrillo-L\u00f3pez N, Panizo S, Locatelli F, Ketteler M, London GM, Naves-D\u00edez M, Alonso-Montes C, Cannata-And\u00eda JB, Fern\u00e1ndez-Mart\u00edn JL. Mineral and bone metabolism markers and mortality in diabetic patients on haemodialysis.\u00a0<em>Nephrol Dial Transplant<\/em>. 2023,38:2589-2597. DOI: 10.1093\/ndt\/gfad122<\/li>\n\n\n\n<li>Aguilar A, Gifre L, Ure\u00f1a-Torres P, Carrillo-L\u00f3pez N, Rodr\u00edguez-Garc\u00eda M, Mass\u00f3 E, da Silva I, L\u00f3pez-B\u00e1ez V, S\u00e1nchez-Bay\u00e1 M, Prior-Espa\u00f1ol A, Urrutia M, Paul J, Bustos MC, Vila A, Garnica-Le\u00f3n I,\u00a0<strong>Navarro-Gonz\u00e1lez JF<\/strong>, Mateo L, Bover J. Pathophysiology of bone disease in chronic kidney disease: from basics to renal osteodystrophy and osteoporosis.\u00a0<em>Front Physiol<\/em>. 2023,14:1177829. DOI: 10.3389\/fphys.2023.1177829<\/li>\n\n\n\n<li>Mart\u00edn-V\u00edrgala J, Fern\u00e1ndez Villabrille S, Mart\u00edn Carro B, Tamargo G\u00f3mez I,\u00a0<strong>Navarro-Gonz\u00e1lez JF<\/strong>, Mora-Fern\u00e1ndez C, Calleros L, Astudillo Cort\u00e9s E, Avello Llano N, Mari\u00f1o G, Dusso AS, Alonso Montes C, Panizo S, Cannata-And\u00eda JB, Naves D\u00edaz M, Carrillo L\u00f3pez N. Serum and urinary soluble \u03b1-klotho as markers of kidney and vascular impairment.\u00a0<em>Nutrients<\/em>. 2023 Mar 18;15(6):1470. DOI: 10.3390\/nu15061470<\/li>\n\n\n\n<li>Torregrosa JV, Bover J, Rodr\u00edguez Portillo M, Gonz\u00e1lez Parra E, Dolores Arenas M, Caravaca F, Gonz\u00e1lez Casaus ML, Mart\u00edn-Malo A,\u00a0<strong>Navarro-Gonz\u00e1lez JF<\/strong>, Lorenzo V, Molina P, Rodr\u00edguez M, Cannata Andia J. Recommendations of the Spanish Society of Nephrology for the management of mineral and bone metabolism disorders in patients with chronic kidney disease: 2021 (SEN-MM).\u00a0<em>Nephrology<\/em>. 2023 Jun:43 Suppl 1:1-36. DOI: 10.1016\/j.nefroe.2023.03.003<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Representative publications from recent years<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Mart\u00edn-N\u00fa\u00f1ez E, Donate-Correa J, Kannengiesser C, De Brauwere DP, Leroy C, Oudin C, Friedlander G, Prieto-Mor\u00edn C, Tagua VG, Ure\u00f1a-Torres PA,\u00a0<strong>Navarro-Gonz\u00e1lez JF<\/strong>. A novel heterozygous deletion variant in KLOTHO gene leading to haploinsufficiency and impairment of fibroblast growth factor 23 signaling pathway.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=A+novel+heterozygous+deletion+variant+in+KLOTHO+gene+leading+to+haploinsufficiency+and+impairment+of+fibroblast+growth+factor+23+signaling+pathway\" target=\"_blank\" rel=\"noreferrer noopener\"><em>J Clin Med<\/em>.<\/a>\u00a02019 Apr;8(4). pii: E500. DOI: 10.3390\/jcm8040500<\/li>\n\n\n\n<li><strong>Navarro-Gonz\u00e1lez JF<\/strong>, S\u00e1nchez-Ni\u00f1o MD, Donate-Correa J, Mart\u00edn-N\u00fa\u00f1ez E, Ferri C, P\u00e9rez-Delgado N, G\u00f3rriz JL, Mart\u00ednez-Castelao A, Ortiz A, Mora-Fern\u00e1ndez C. Effects of pentoxifylline on soluble Klotho concentrations and renal tubular cell expression in diabetic kidney disease.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Effects+of+pentoxifylline+on+soluble+Klotho+concentrations+and+renal+tubular+cell+expression+in+diabetic+kidney+disease\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Diabetes Care<\/em>.<\/a>\u00a02018 Aug;41(8):1817-1820. DOI: 10.2337\/dc18-0078<\/li>\n\n\n\n<li>Donate-Correa J, Henriquez-Palop F, Mart\u00edn-N\u00fa\u00f1ez E, P\u00e9rez-Delgado N, Muros-de-Fuentes M, Mora-Fernandez C,\u00a0<strong>Navarro-Gonz\u00e1lez JF<\/strong>. Effect of Paricalcitol on FGF-23 and Klotho in kidney transplant recipients.\u00a0<em>Transplantation<\/em>. 2016;100(11):2432-2438. DOI: 10.1097\/TP.0000000000001339<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Research in Renal and Cardiovascular Disease Principal Investigator Juan Francisco Navarro Gonz\u00e1lez, MD, PhD Head of the Research Unit, HUNSC Collaborating Researchers (PhDs) External Collaborators and Associate Researchers PhD Students and Early-Stage Researchers Technical and Management Staff Research Areas Funded Projects Publications 2023 Representative publications from recent years\u2026<\/p>","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/template-frontpage.php","meta":{"footnotes":""},"class_list":["post-267","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/wp-json\/wp\/v2\/pages\/267","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/wp-json\/wp\/v2\/comments?post=267"}],"version-history":[{"count":5,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/wp-json\/wp\/v2\/pages\/267\/revisions"}],"predecessor-version":[{"id":1024,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/wp-json\/wp\/v2\/pages\/267\/revisions\/1024"}],"wp:attachment":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/wp-json\/wp\/v2\/media?parent=267"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}