{"id":278,"date":"2021-03-11T11:52:24","date_gmt":"2021-03-11T11:52:24","guid":{"rendered":"http:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/?page_id=278"},"modified":"2026-07-08T12:19:48","modified_gmt":"2026-07-08T12:19:48","slug":"respuesta-inflamatoria-y-dano-tisular-en-la-artritis-reumatoide","status":"publish","type":"page","link":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/respuesta-inflamatoria-y-dano-tisular-en-la-artritis-reumatoide\/","title":{"rendered":"Inflammatory response and tissue damage in rheumatoid arthritis"},"content":{"rendered":"<div class=\"wp-block-stackable-columns alignfull stk-block-columns stk-block stk-49c10bb stk-block-background stk--has-background-overlay\" data-block-id=\"49c10bb\"><style>.stk-49c10bb {background-color:linear-gradient(135deg,rgb(161,9,157) 1%,rgb(63,37,132) 100%) !important;margin-top:-3% !important;margin-bottom:3% !important;}.stk-49c10bb:before{background-image:linear-gradient(135deg,rgb(161,9,157) 1%,rgb(63,37,132) 100%) !important;}.stk-49c10bb-column{justify-content:center !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-49c10bb-column stk--flex alignfull\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-429e70e\" data-v=\"4\" data-block-id=\"429e70e\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-429e70e-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-429e70e-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-616317e\" id=\"respuesta-inflamatoria-y-dano-tisular-en-la-artritis-reumatoide\" data-block-id=\"616317e\"><style>.stk-616317e {align-items:center !important;display:flex !important;}.stk-616317e .stk-block-heading__text{color:#ffffff !important;font-weight:800 !important;}<\/style><h2 class=\"stk-block-heading__text has-text-color has-text-align-center\">Inflammatory response and tissue damage in rheumatoid arthritis<\/h2><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-8b59b96\" data-block-id=\"8b59b96\"><style>.stk-8b59b96 .stk--block-align-8b59b96{align-items:flex-start !important;}.stk-8b59b96 {margin-top:25px !important;}.stk-8b59b96-column{--stk-columns-spacing:0px !important;--stk-column-gap:50px !important;}@media screen and (max-width: 767px){.stk-8b59b96-column{row-gap:var(--stk--preset--spacing--60, 2.25rem) !important;}}<\/style><div class=\"stk-row stk-inner-blocks stk--block-align-8b59b96 stk-block-content stk-content-align stk-8b59b96-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-dbb7e15\" data-v=\"4\" data-block-id=\"dbb7e15\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-dbb7e15-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-dbb7e15-inner-blocks\">\n<h4 class=\"wp-block-heading\"><strong>Principal Investigator<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><a href=\"https:\/\/portalciencia.ull.es\/investigadores\/81156\/detalle\" target=\"_blank\" rel=\"noreferrer noopener\">Jos\u00e9 Federico D\u00edaz Gonz\u00e1lez<\/a>, MD, PhD<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Professor of Medicine; Department of Internal Medicine, Dermatology and Psychiatry, ULL \u2013 Head of the Rheumatology Service, HUC<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Collaborating doctors<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Javier Rafael Castro Hern\u00e1ndez, PhD (Assistant Professor; Department of Physical Medicine and Pharmacology, ULL \u2013 until 05\/2023)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Clinical medical collaborators<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Judith M\u00aa L\u00f3pez Fern\u00e1ndez, MD, PhD (Attending Physician; Endocrinology Department, HUC)<\/li>\n\n\n\n<li>Iv\u00e1n Ferraz Amaro, MD, PhD (Attending Physician; Rheumatology Service, HUC)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>PhD students and researchers in training<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Sergio Iv\u00e1n Santos Concepci\u00f3n (Doctoral Program in Health Sciences ULL, FIISC, Spanish Society of Rheumatology)<\/li>\n\n\n\n<li>No\u00e9 Adal Brito Garc\u00eda (Doctoral Program in Medical and Pharmaceutical Sciences, Development and Quality of Life, ULL)<\/li>\n\n\n\n<li>Virginia Dom\u00ednguez Pimentel (Doctoral Program in Health Sciences, ULL)<\/li>\n\n\n\n<li>Ana Bel\u00e9n Llanos Mart\u00edn (Doctoral Program in Health Sciences ULL, thesis defended 19\/05\/2023)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Lines of research<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Determining the role of oxygen free radicals in regulating the early stages of the inflammatory response<\/li>\n\n\n\n<li>Study of the in vivo effect of substances with anti-L-selectin activity on neutrophil migration<\/li>\n\n\n\n<li>Study of the modulatory role of alpha 2 adrenergic receptors in the acute inflammatory response<\/li>\n\n\n\n<li>The involvement of cytokines and chemokines in the pathogenesis of rheumatoid arthritis, psoriatic arthropathy, and Sj\u00f6gren&#039;s syndrome<\/li>\n\n\n\n<li>Study of the capacity of pancreatic tissue in the differentiation of adult stem cells into pancreatic endocrine cells<\/li>\n\n\n\n<li>Modulation of the acute and chronic inflammatory response of LXR receptors<\/li>\n\n\n\n<li>Physical activity in patients with chronic joint diseases. Relationship between clinical activity and movement capacity. Analysis of physical activity in patients with psoriatic arthritis.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Effect of cytokines and the inflammatory response on insulin resistance, cholesterol flux, and PCSK9<\/li>\n\n\n\n<li>Abdominal adiposity and body composition in patients with rheumatoid arthritis<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Funded projects<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Regulation of fat inflammation in human obesity. Role of chemokine system and alpha2-adrenergic receptors in macrophage accumulation in adipose tissue (PI21\/00406). IP: Federico D\u00edaz. Carlos III Health Institute (01\/2022 \u2013 12\/2024, \u20ac120,000)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Publications 2023<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Montero-Pastor N, S\u00e1nchez-Costa JT, Guerra-Rodr\u00edguez M, S\u00e1nchez-Alonso F, Moriano C, Loricera J,\u00a0<strong>D\u00edaz-Gonz\u00e1lez F<\/strong>. Development of a web tool to calculate the cumulative dose of glucocorticoids.\u00a0<em>Clinical Rheumatology<\/em>. 2023;19(1):1-5. DOI: 10.1016\/J.REUMA.2022.04.004<\/li>\n\n\n\n<li>Michelsen B, \u00d8stergaard M, Nissen MJ, Ciurea A, M\u00f6ller B, \u00d8rnbjerg LM, et al. (<strong>D\u00edaz-Gonz\u00e1lez F)<\/strong>, Bustabad-Reyes S. Differences and similarities between the EULAR\/ASAS-EULAR and national recommendations for treatment of patients with psoriatic arthritis and axial spondyloarthritis across Europe.\u00a0<em>The Lancet Regional Health \u2013 Europe<\/em>. 2023 Oct;33:100706. DOI: 10.1016\/j.lanepe.2023.100706<\/li>\n\n\n\n<li>\u00c1lvaro-Gracia JM, Sanchez-Piedra C, Culqui D, Rosello R, Garcia-Dorta A, Campos C, Manrique-Arija S, Ruiz-Montesinos D, Ros-Vilamajo I, Rodr\u00edguez-Lozano C, Freire-Gonz\u00e1lez M, Caliz R, Bohorquez C, Mateo Soria L, Busquets N, Castrejon I, S\u00e1nchez-Alonso F, Gonz\u00e1lez-D\u00e1vila E,\u00a0<strong>Diaz-Gonzalez F<\/strong>. Effects of COVID-19 vaccination on disease activity in patients with rheumatoid arthritis and psoriatic arthritis on targeted therapy in the COVIDSER study.\u00a0<em>RMD open<\/em>. 2023 Mar;9(1):e002936. DOI: 10.1136\/rmdopen-2022-002936<\/li>\n\n\n\n<li>Torre Alonso JC, Almod\u00f3var Gonz\u00e1lez R, Montilla Morales C, Sanz Sanz J,\u00a0<strong>D\u00edaz Gonz\u00e1lez F<\/strong>, Pascual Alfonso E, Gratac\u00f3s J. Expert recommendations for the use of apremilast in psoriatic arthritis.\u00a0<em>Clinical Rheumatology<\/em>. 2023;19(1):34-44. DOI: 10.1016\/J.REUMA.2022.01.002<\/li>\n\n\n\n<li>Pombo-Su\u00e1rez M, Seoane-Mato D,\u00a0<strong>D\u00edaz-Gonz\u00e1lez F<\/strong>, S\u00e1nchez-Alonso F, S\u00e1nchez-Jare\u00f1o M, Cea-Calvo L, Castrej\u00f3n I. Four-year retention rate of golimumab administered after discontinuation of non-TNF inhibitors in patients with inflammatory rheumatic diseases.\u00a0<em>Advances in Rheumatology<\/em>. 2023 Jun 7;63(1):25. DOI: 10.1186\/s42358-023-00296-1<\/li>\n\n\n\n<li>Garc\u00eda-Gonz\u00e1lez M, G\u00f3mez-Bernal F, Quevedo-Abeledo JC, Fern\u00e1ndez-Cladera Y, Gonz\u00e1lez-Rivero AF, de Vera-Gonz\u00e1lez A, de la Rua-Figueroa I, L\u00f3pez-Mejias R,\u00a0<strong>D\u00edaz-Gonz\u00e1lez F<\/strong>, Gonz\u00e1lez-Gay M\u00c1, Ferraz-Amaro I. Full characterization of the three pathways of the complement system in patients with systemic lupus erythematosus.\u00a0<em>Frontiers in Immunology<\/em>. 2023 Apr 21:14:1167055. DOI: 10.3389\/fimmu.2023.1167055<\/li>\n\n\n\n<li>Garc\u00eda-Gonz\u00e1lez M, G\u00f3mez-Bernal F, Quevedo-Abeledo JC, Fern\u00e1ndez-Cladera Y, Gonz\u00e1lez-Rivero AF, L\u00f3pez-Mej\u00edas R,\u00a0<strong>D\u00edaz-Gonz\u00e1lez F<\/strong>, Gonz\u00e1lez-Gay M\u00c1, Ferraz-Amaro I. HDL Cholesterol Efflux and the Complement System Are Linked in Systemic Lupus Erythematosus.\u00a0<em>Journal of Clinical Medicine<\/em>. 2023;12(16). DOI: 10.3390\/jcm12165405<\/li>\n\n\n\n<li>Pombo-Su\u00e1rez M, Seoane-Mato D,\u00a0<strong>D\u00edaz-Gonz\u00e1lez F<\/strong>, Cea-Calvo L, S\u00e1nchez-Alonso F, S\u00e1nchez-Jare\u00f1o M, Jovani V, Garc\u00eda-Magall\u00f3n B, Mart\u00ednez-Gonz\u00e1lez O, Campos-Fern\u00e1ndez C, Manero J, D\u00edaz-Torne C, Boh\u00f3rquez C, Ros-Vilamaj\u00f3 I, P\u00e9rez-Vera Y, Castrej\u00f3n I. Long-term retention of golimumab treatment in clinical practice in a large cohort of patients with rheumatoid arthritis, axial spondyloarthritis and psoriatic arthritis.\u00a0<em>Musculoskeletal Care<\/em>. 2023 Mar;21(1):189-197. DOI: 10.1002\/msc.1684<\/li>\n\n\n\n<li><strong>D\u00edaz-Gonz\u00e1lez F<\/strong>, Hern\u00e1ndez-Hern\u00e1ndez MV. Rheumatoid arthritis.\u00a0<em>Clinical Medicine<\/em>. 2023 Dec 22;161(12):533-542. DOI: 10.1016\/j.medcli.2023.07.014<\/li>\n\n\n\n<li>Ferraz-Amaro I, Santos-Concepci\u00f3n S, Castro J, Hern\u00e1ndez-Hern\u00e1ndez MV, Tejera-Segura B, Luna C, Delgado-Fr\u00edas E,\u00a0<strong>D\u00edaz-Gonz\u00e1lez F<\/strong>. Tocilizumab-related hypertriglyceridemia is independent of key molecules regulating lipid metabolism.\u00a0<em>European Journal of Clinical Investigation<\/em>. 2023 Sep;53(9):e14006. DOI: 10.1111\/eci.14006<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Other representative publications from recent years<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Dom%C3%ADnguez-Luis%20MJ%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30443903\" target=\"_blank\" rel=\"noreferrer noopener\">Dom\u00ednguez-Luis MJ<\/a>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Armas-Gonz%C3%A1lez%20E%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30443903\" target=\"_blank\" rel=\"noreferrer noopener\">Armas-Gonz\u00e1lez E<\/a>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Herrera-Garc%C3%ADa%20A%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30443903\" target=\"_blank\" rel=\"noreferrer noopener\">Herrera-Garc\u00eda A<\/a>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Arce-Franco%20M%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30443903\" target=\"_blank\" rel=\"noreferrer noopener\">Arce-Franco M<\/a>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Feria%20M%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30443903\" target=\"_blank\" rel=\"noreferrer noopener\">M Fair<\/a>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Vicente-Manzanares%20M%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30443903\" target=\"_blank\" rel=\"noreferrer noopener\">Vicente-Manzanares M<\/a>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Mart%C3%ADnez-Ruiz%20A%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30443903\" target=\"_blank\" rel=\"noreferrer noopener\">Mart\u00ednez-Ruiz A<\/a>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=S%C3%A1nchez-Madrid%20F%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30443903\" target=\"_blank\" rel=\"noreferrer noopener\">S\u00e1nchez-Madrid F<\/a>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=D%C3%ADaz-Gonz%C3%A1lez%20F%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30443903\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>D\u00edaz-Gonz\u00e1lez F<\/strong><\/a>. L-selectin expression is regulated by CXCL8-induced reactive oxygen species produced during human neutrophil rolling.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=L-selectin+expression+is+regulated+by+CXCL8-induced+reactive+oxygen+species+produced+during+human+neutrophil+rolling\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Eur J Immunol<\/em>.<\/a>\u00a02019 Mar;49(3):386-397. DOI: 10.1002\/eji.201847710<\/li>\n\n\n\n<li>\u00c1lvaro-Gracia JM, Jover JA, Garc\u00eda-Vicu\u00f1a R, Carre\u00f1o L, Alonso A, Marsal S, Blanco F, Mart\u00ednez-Taboada VM, Taylor P, Mart\u00edn-Mart\u00edn C, DelaRosa O, Tagarro I,\u00a0<strong>D\u00edaz-Gonz\u00e1lez F.<\/strong>\u00a0Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis (Cx611): results of a multicenter, dose escalation, randomized, single-blind, placebo-controlled phase Ib\/IIa clinical trial.\u00a0<em>Ann Rheum Dis<\/em>. 2017 Jan;76(1):196-202. DOI: 10.1136\/annrheumdis-2015-208918<\/li>\n\n\n\n<li>Cutolo M, Myerson GE, Fleischmann RM, Liote F,\u00a0<strong>D\u00edaz-Gonz\u00e1lez F<\/strong>, Van den Bosch F, Mazo-Ortega H, Feist E, Shan K, Hu C, Stevens RM, Poder A. A phase III, randomized, controlled trial of Apremilast in patients with psoriatic arthritis: results of the PALACE 2 trial.\u00a0<em>J Rheumatol<\/em>. 2016 Sep;43(9):1724-34. DOI: 10.3899\/jrheum.151376<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Inflammatory Response and Tissue Damage in Rheumatoid Arthritis. Principal Investigator: Jos\u00e9 Federico D\u00edaz Gonz\u00e1lez, MD, PhD, Professor of Medicine; Department of Internal Medicine, Dermatology and Psychiatry, ULL \u2013 Head of the Rheumatology Service, HUC. Collaborating Physicians. Clinical Collaborating Physicians. PhD Students and Research Trainees. Research Areas. Funded Projects. Publications 2023. Other\u2026<\/p>","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/template-frontpage.php","meta":{"footnotes":""},"class_list":["post-278","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/wp-json\/wp\/v2\/pages\/278","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/wp-json\/wp\/v2\/comments?post=278"}],"version-history":[{"count":6,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/wp-json\/wp\/v2\/pages\/278\/revisions"}],"predecessor-version":[{"id":1026,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/wp-json\/wp\/v2\/pages\/278\/revisions\/1026"}],"wp:attachment":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/wp-json\/wp\/v2\/media?parent=278"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}