{"id":520,"date":"2022-06-07T17:37:18","date_gmt":"2022-06-07T17:37:18","guid":{"rendered":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/?page_id=520"},"modified":"2024-09-11T13:39:05","modified_gmt":"2024-09-11T13:39:05","slug":"fisiopatologia-del-metabolismo-mineral","status":"publish","type":"page","link":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/fisiopatologia-del-metabolismo-mineral\/","title":{"rendered":"Pathophysiology of mineral metabolism"},"content":{"rendered":"<div class=\"page-header\">\n<h1>Pathophysiology of mineral metabolism<\/h1>\n<\/div>\n<div class=\"content\">\n<h4><b>Principal Investigator<\/b><\/h4>\n<table class=\"jefe\">\n<tbody>\n<tr>\n<td class=\"provisional\"><\/td>\n<td><span style=\"font-weight: 400;\"><strong>Javier Donate Correa, PhD<\/strong> <\/span><\/p>\n<p><span style=\"font-weight: 400;\">Michael Servetus Contract. Carlos III Health Institute, ISCIII, CP20\/00122<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><b>External collaborators<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Manuel Jos\u00e9 Morales Gonz\u00e1lez (Head of the Medical Oncology Service, HUNSC)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Carolina Hern\u00e1ndez Carballo (FEA Internal Medicine Service, HUNSC)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Juan F. Navarro Gonz\u00e1lez (Head of Service of the Research Unit, HUNSC)<\/span><\/li>\n<\/ul>\n<p><b>PhD students and researchers in training<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ainhoa Gonz\u00e1lez Luis (Doctoral Program in Health Sciences ULL. Contract PFIS-FI22\/00213, ISCIII)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rebeca Navarro Alonso (hired by the INVESTIGO 2023 Program, Government of the Canary Islands)<\/span><\/li>\n<\/ul>\n<p><b>Technical or management staff<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Alberto Mart\u00edn Olivera (Laboratory Technician, Carlos III Health Institute, ISCIII, CP20\/00122)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Juan Diego Carlos Monz\u00f3n (Laboratory Technician, HUNSC Research Unit)<\/span><\/li>\n<\/ul>\n<p><b>Lines of research<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><i><span style=\"font-weight: 400;\">Effects of mineral metabolism disorders on the development of diabetes<\/span><\/i><span style=\"font-weight: 400;\">. Determination of the effects derived from alterations in phosphorus metabolism and its regulators on the functionality of the pancreatic beta cell.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><i><span style=\"font-weight: 400;\">Inflammatory mechanisms mediated by alterations in the FGF23\/Klotho system in patients with kidney disease<\/span><\/i><span style=\"font-weight: 400;\">. Investigate the pro-inflammatory processes associated with the increase in levels of fibroblast growth factor 23 (FGF23) and the decrease in those of its co-receptor Klotho in patients with chronic kidney disease.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><i><span style=\"font-weight: 400;\">Determination of the possible dual effect of FGF23 on the activation of the Ras\/Raf\/MAPK and CN\/NFAT pathways in pancreatic ductal adenocarcinoma<\/span><\/i><span style=\"font-weight: 400;\">. Investigate the possible role of FGF23 in the activation of signaling pathways related to PDAC development.<\/span><\/li>\n<\/ul>\n<p><b>Funded projects<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Pathophysiological implications of fibroblast growth factor 23 imbalances in the development of diabetes (PI21\/01037). PI: Javier Donate Correa. Carlos III Health Institute, ISCIII (01\/01\/2022 \u2013 31\/12\/2024, \u20ac75,020)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Inflammatory mechanisms mediated by fibroblast growth factor 23 in patients with kidney disease (PIFIISC21\/08). PI: Javier Donate Correa. Canary Islands Foundation Institute of Health Research of the Canary Islands, FIISC (2022-2023, \u20ac22,185)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fibroblast growth factor 23 (FGF23) and the inflammatory process in renal patients (OA22\/107). PI: Javier Donate Correa and Carolina Hern\u00e1ndez Carballo. MAPFRE Canarias (2022-2023, \u20ac20,000)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dual effect of fibroblast growth factor 23 on the activation of the Ras\/Raf\/MAPK and CN\/NFAT pathways in pancreatic ductal adenocarcinoma (OA23\/072). PI: Javier Donate Correa. DISA Foundation (2023-2024, \u20ac25,000)<\/span><\/li>\n<\/ul>\n<p><b>Publications 2023<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Donate-Correa J<\/b><span style=\"font-weight: 400;\">, Mart\u00edn-N\u00fa\u00f1ez E, Mora-Fern\u00e1ndez C, Gonz\u00e1lez-Luis A, Mart\u00edn-Olivera A, <\/span><b>Navarro-Gonz\u00e1lez JF<\/b><span style=\"font-weight: 400;\">. Association of Klotho with Coronary Artery Disease in Subjects with Type 2 Diabetes Mellitus and Preserved Kidney Function: A Case-Control Study. <\/span><i><span style=\"font-weight: 400;\">International Journal of Molecular Sciences<\/span><\/i><span style=\"font-weight: 400;\">. 2023 Aug 30;24(17):13456. DOI: 10.3390\/ijms241713456<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Donate-Correa J<\/b><span style=\"font-weight: 400;\">, Mart\u00edn-N\u00fa\u00f1ez E, Mora-Fern\u00e1ndez C, Gonz\u00e1lez-Luis A, Mart\u00edn-Olivera A, <\/span><b>Navarro-Gonz\u00e1lez JF<\/b><span style=\"font-weight: 400;\">. Associations between Inflammation, Hemoglobin Levels, and Coronary Artery Disease in Non-Albuminuric Subjects with and without Type 2 Diabetes Mellitus. <\/span><i><span style=\"font-weight: 400;\">International Journal of Molecular Sciences<\/span><\/i><span style=\"font-weight: 400;\">. 2023;24(18). 2023 Sep 15;24(18):14131. DOI: 10.3390\/ijms241814131<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mart\u00edn-Carro B, <\/span><b>Donate-Correa J<\/b><span style=\"font-weight: 400;\">, Fern\u00e1ndez-Villabrille S, Mart\u00edn-V\u00edrgala J, Panizo S, Carrillo-L\u00f3pez N, Mart\u00ednez-Arias L, <\/span><b>Navarro-Gonz\u00e1lez JF<\/b><span style=\"font-weight: 400;\">, Naves-D\u00edaz M, Fern\u00e1ndez-Mart\u00edn JL, Alonso-Montes C, Cannata-And\u00eda JB. Experimental Models to Study Diabetes Mellitus and Its Complications: Limitations and New Opportunities. <\/span><i><span style=\"font-weight: 400;\">International Journal of Molecular Sciences<\/span><\/i><span style=\"font-weight: 400;\">. 2023 Jun 18;24(12):10309. DOI: 10.3390\/ijms241210309<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Donate-Correa J<\/b><span style=\"font-weight: 400;\">, Mart\u00edn-N\u00fa\u00f1ez E, Martin-Olivera A, Mora-Fern\u00e1ndez C, <\/span><b>Tagua VG<\/b><span style=\"font-weight: 400;\">, Ferri CM, L\u00f3pez-Castillo \u00c1, Delgado-Molinos A, L\u00f3pez-Tarruella VC, Ar\u00e9valo-G\u00f3mez MA, P\u00e9rez-Delgado N, Gonz\u00e1lez-Luis A, <\/span><b>Navarro-Gonz\u00e1lez JF<\/b><span style=\"font-weight: 400;\">. Klotho inversely relates with carotid intima-media thickness in atherosclerotic patients with normal renal function (eGFR \u226560 mL\/min\/1.73m2): a proof-of-concept study. <\/span><i><span style=\"font-weight: 400;\">Frontiers in Endocrinology<\/span><\/i><span style=\"font-weight: 400;\">. 2023;14:1146012. DOI: <\/span><a href=\"https:\/\/doi.org\/10.3389%2Ffendo.2023.1146012\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">10.3389\/fendo.2023.1146012<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Donate-Correa J<\/b><span style=\"font-weight: 400;\">, Mart\u00edn-Carro B, Cannata-And\u00eda JB, Mora-Fern\u00e1ndez C, <\/span><b>Navarro-Gonz\u00e1lez JF<\/b><span style=\"font-weight: 400;\">. Klotho, Oxidative Stress, and Mitochondrial Damage in Kidney Disease. <\/span><i><span style=\"font-weight: 400;\">Antioxidants<\/span><\/i><span style=\"font-weight: 400;\">. 2023 Jan 20;12(2):239. DOI: 10.3390\/antiox12020239<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mart\u00edn-Carro B, Mart\u00edn-V\u00edrgala J, Fern\u00e1ndez-Villabrille S, Fern\u00e1ndez-Fern\u00e1ndez A, P\u00e9rez-Basterrechea M, <\/span><b>Navarro-Gonz\u00e1lez JF<\/b><span style=\"font-weight: 400;\">, <\/span><b>Donate-Correa J<\/b><span style=\"font-weight: 400;\">, Mora-Fern\u00e1ndez C, Dusso AS, Carrillo-L\u00f3pez, N, Panizo S, Naves-D\u00edaz M, Fern\u00e1ndez-Mart\u00edn JL, Cannata-And\u00eda JB, Alonso-Montes C. Role of Klotho and AGE\/RAGE-Wnt\/\u03b2-Catenin Signaling Pathway on the Development of Cardiac and Renal Fibrosis in Diabetes. <\/span><i><span style=\"font-weight: 400;\">International Journal of Molecular Sciences<\/span><\/i><span style=\"font-weight: 400;\">. 2023;24(6). DOI: 10.3390\/IJMS24065241<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rayego-Mateos S, Rodrigues-Diez RR, Fernandez-Fernandez B, Mora-Fern\u00e1ndez C, Marchant V, <\/span><b>Donate-Correa J<\/b><span style=\"font-weight: 400;\">, <\/span><b>Navarro-Gonz\u00e1lez JF<\/b><span style=\"font-weight: 400;\">, Ortiz A, Ruiz-Ortega M. Targeting inflammation to treat diabetic kidney disease: the road to 2030. <\/span><i><span style=\"font-weight: 400;\">Kidney International<\/span><\/i><span style=\"font-weight: 400;\">. 2023;103(2):282-96. DOI: 10.1016\/J.KINT.2022.10.030<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Donate-Correa J<\/b><span style=\"font-weight: 400;\">, Matos-Perdomo E, Gonz\u00e1lez-Luis A, Mart\u00edn-Olivera A, Ortiz A, Mora-Fern\u00e1ndez C, <\/span><b>Navarro-Gonz\u00e1lez JF<\/b><span style=\"font-weight: 400;\">. The Value of Klotho in Kidney Transplantation. <\/span><i><span style=\"font-weight: 400;\">Transplantation<\/span><\/i><span style=\"font-weight: 400;\">. 2023;107(3):616-27. DOI: 10.1097\/TP.0000000000004331<\/span><\/li>\n<\/ul>\n<p><b>Other representative publications from recent years<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mart\u00edn-N\u00fa\u00f1ez E, <\/span><b>Donate-Correa J<\/b><span style=\"font-weight: 400;\">, Ferri C, L\u00f3pez-Castillo A, Delgado-Molinos A, Hern\u00e1ndez-Carballo C, P\u00e9rez-Delgado N, Rodr\u00edguez-Ramos S, Cerro-L\u00f3pez P, <\/span><b>Tagua VG<\/b><span style=\"font-weight: 400;\">, Mora-Fern\u00e1ndez C, <\/span><b>Navarro-Gonz\u00e1lez JF<\/b><span style=\"font-weight: 400;\">. Association between serum levels of Klotho and inflammatory cytokines in cardiovascular disease: A case-control study. <\/span><i><span style=\"font-weight: 400;\">Aging<\/span><\/i><span style=\"font-weight: 400;\">. 2020 Jan;12(2):1952-1964. DOI: 10.18632\/aging.102734<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Donate-Correa J<\/b><span style=\"font-weight: 400;\">, Ferri CM, Mart\u00edn-N\u00fa\u00f1ez E, P\u00e9rez-Delgado N, Gonz\u00e1lez-Luis A, Mora-Fern\u00e1ndez C, <\/span><b>Navarro-Gonz\u00e1lez JF<\/b><span style=\"font-weight: 400;\">. Klotho as a biomarker of subclinical atherosclerosis in patients with moderate to severe chronic kidney disease. <\/span><i><span style=\"font-weight: 400;\">Scientific Reports<\/span><\/i><span style=\"font-weight: 400;\">. 2021 Aug;11(1):15877. DOI: 10.1038\/s41598-021-95488-4<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Donate-Correa J<\/b><span style=\"font-weight: 400;\">, Mart\u00edn-N\u00fa\u00f1ez E, Gonz\u00e1lez-Luis A, Ferri CM, Luis-Rodr\u00edguez D, <\/span><b>Tagua VG<\/b><span style=\"font-weight: 400;\">, Mora-Fern\u00e1ndez C, <\/span><b>Navarro-Gonz\u00e1lez JF<\/b><span style=\"font-weight: 400;\">. Pathophysiological implications of imbalances in fibroblast growth factor 23 in the development of diabetes. <\/span><i><span style=\"font-weight: 400;\">Journal of Clinical Medicine<\/span><\/i><span style=\"font-weight: 400;\">. 2021 Jun;10(12):2583. DOI: 10.3390\/jcm10122583<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Pathophysiology of Mineral Metabolism. Principal Investigator: Javier Donate Correa, PhD. Miguel Servet Contract. Carlos III Health Institute, ISCIII, CP20\/00122. External Collaborators: Manuel Jos\u00e9 Morales Gonz\u00e1lez (Head of the Medical Oncology Department, HUNSC), Carolina Hern\u00e1ndez Carballo (Attending Physician, Internal Medicine Department, HUNSC), Juan F. Navarro Gonz\u00e1lez (Head of the Research Unit,\u2026<\/p>","protected":false},"author":6,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-520","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/wp-json\/wp\/v2\/pages\/520","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/wp-json\/wp\/v2\/comments?post=520"}],"version-history":[{"count":3,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/wp-json\/wp\/v2\/pages\/520\/revisions"}],"predecessor-version":[{"id":606,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/wp-json\/wp\/v2\/pages\/520\/revisions\/606"}],"wp:attachment":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/en\/wp-json\/wp\/v2\/media?parent=520"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}