{"id":257,"date":"2021-03-11T11:31:15","date_gmt":"2021-03-11T11:31:15","guid":{"rendered":"http:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/?page_id=257"},"modified":"2024-09-11T09:05:57","modified_gmt":"2024-09-11T09:05:57","slug":"estres-replicativo-y-tumorogenesis","status":"publish","type":"page","link":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/estres-replicativo-y-tumorogenesis\/","title":{"rendered":"Estr\u00e9s replicativo y tumorog\u00e9nesis"},"content":{"rendered":"

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Estr\u00e9s replicativo y tumorog\u00e9nesis<\/h1>\n<\/div>\n
\n

Investigador responsable<\/b><\/h4>\n\n\n\n
<\/td>\nRaimundo Freire Betancor<\/a>, PhD<\/strong><\/p>\n

Investigador contratado del SCS\/FIISC; Unidad de Investigaci\u00f3n, HUC<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Investigadores doctores<\/b><\/p>\n

    \n
  • Gregoire Quinet, PhD (investigador postdoctoral, Fundaci\u00f3n Canaria Instituto de Investigaci\u00f3n Sanitaria de Canarias, FIISC)<\/span><\/li>\n<\/ul>\n

    Estudiantes de doctorado e investigadores en formaci\u00f3n<\/b><\/p>\n

      \n
    • Esperanza Hern\u00e1ndez Carralero (Programa de Doctorado Ciencias de la Salud ULL. Beca Agencia Canaria de Investigaci\u00f3n, Innovaci\u00f3n y Sociedad de la Informaci\u00f3n, ACIISI, tesis defendida 03\/2023)<\/span><\/li>\n
    • Gara Rodr\u00edguez Torres (Programa de Doctorado Ciencias de la Salud ULL, Beca Agencia Canaria de Investigaci\u00f3n, Innovaci\u00f3n y Sociedad de la Informaci\u00f3n, ACIISI, 2021-2026)<\/span><\/li>\n
    • Alba Molina de Armas (Programa de Doctorado Ciencias de la Salud ULL. Contrato Fundaci\u00f3n Canaria Instituto de Investigaci\u00f3n Sanitaria de Canarias, FIISC)<\/span><\/li>\n
    • Mar\u00eda Magur\u00e1n Cardiel (Beca Agencia Canaria de Investigaci\u00f3n, Innovaci\u00f3n y Sociedad de la Informaci\u00f3n, ACIISI, 2021-2026)<\/span><\/li>\n<\/ul>\n

      L\u00edneas de investigaci\u00f3n<\/b><\/p>\n

        \n
      • Estudio de nuevas prote\u00ednas que controlan la replicaci\u00f3n del DNA en c\u00e9lulas humanas.<\/span><\/li>\n
      • Estudio de la expresi\u00f3n en c\u00e1ncer de prote\u00ednas de replicaci\u00f3n del DNA.<\/span><\/li>\n
      • Determinaci\u00f3n de ubiquitin hidrolasas implicadas en el control de la inestabilidad gen\u00f3mica en c\u00e9lulas humanas.<\/span><\/li>\n<\/ul>\n

        Proyectos financiados<\/b><\/p>\n

          \n
        • Post-translational modifications in the control of genome stability and their role in cancer and other pathologies (PID2019-109222RB-I00). IP: Raimundo Freire y Veronique Smits. Ministerio de Ciencia e Innovaci\u00f3n (06\/2020 – 05\/2023, 278.300 \u20ac)<\/span><\/li>\n
        • Control enzim\u00e1tico del mantenimiento de la integridad del genoma: mecanismos moleculares y oportunidades para el tratamiento del c\u00e1ncer (PID2022-139691OB-I00). IP: Raimundo Freire y Veronique Smits. Ministerio de Ciencia e Innovaci\u00f3n (10\/2023 – 09\/2026, 400.000 \u20ac)<\/span><\/li>\n
        • Caracterizaci\u00f3n de la ubiquitin hidrolasa USP37 en estabilidad gen\u00f3mica: oportunidades para el tratamiento del c\u00e1ncer. IP: Gregorie Quinet. Fundaci\u00f3n DISA (2023-2024, 25.000 \u20ac)<\/span><\/li>\n<\/ul>\n

          Publicaciones 2023<\/b><\/p>\n

            \n
          • Hern\u00e1ndez\u2010Carralero E, Cabrera E, Rodr\u00edguez-Torres G, Hern\u00e1ndez-Reyes Y, Singh AN, Santa-Mar\u00eda C, Fern\u00e1ndez-Justel JM, Janssens RC, Marteijn JA, Evert BO, Mailand N, G\u00f3mez M, Ramadan K, <\/span>Smits VAJ<\/b>, <\/span>Freire R<\/b>. ATXN3 controls DNA replication and transcription by regulating chromatin structure. <\/span>Nucleic acids research<\/span><\/i>. 2023;51(11):5396-413. DOI: 10.1093\/nar\/gkad212<\/span><\/li>\n
          • Pajenda S, Gerges DA, <\/span>Freire R<\/b>, Wagner L, Hevesi Z, Aiad M, Eder M, Schmidt A, Winnicki W, Eskandary FA. Acute Kidney Injury and BK Polyomavirus in Urine Sediment Cells.. <\/span>Int J Mol Sci<\/span><\/i>. 2023 Dec 15;24(24):17511. doi: 10.3390\/ijms242417511<\/span><\/li>\n
          • Moro RN, Biswas U, Kharat SS, Duzanic FD, Das P, Stavrou M, Raso MC, <\/span>Freire R<\/b>, Chaudhuri AR, Sharan SK, Penengo L. Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15. <\/span>Nat Commun<\/span><\/i>. 2023 Oct 2;14(1):6140. doi: 10.1038\/s41467-023-41801-w<\/span><\/li>\n
          • Barroso-Chinea P, Salas-Hern\u00e1ndez J<\/b>, <\/span>Cruz-Muros I<\/b>, <\/span>L\u00f3pez-Fern\u00e1ndez J<\/b>, <\/span>Freire R<\/b>, <\/span>Afonso-Oramas D.<\/b> Expression of RAD9B in the mesostriatal system of rats and humans: Overexpression in a 6-OHDA rat model of Parkinson’s disease. <\/span>Ann Anat<\/span><\/i>. 2023 Oct;250:152135. doi: 10.1016\/j.aanat.2023.152135<\/span><\/li>\n<\/ul>\n

            Otras publicaciones representativas de los \u00faltimos a\u00f1os<\/b><\/p>\n

              \n
            • Cabrera E, Hern\u00e1ndez-P\u00e9rez S, Koundrioukoff S, Debatisse M, Kim D, Smolka MB, <\/span>Freire R, <\/b>Gillespie DA. PERK inhibits DNA replication during the Unfolded Protein Response via Claspin and Chk1. <\/span>Oncogene<\/span><\/i>. 2017 Feb 2;36(5):678-686. DOI: 10.1038\/onc.2016.239<\/span><\/li>\n
            • Hernandez-Perez S, Cabrera E, <\/span>Salido E<\/b>, Lim M, Reid L, Lakhani SR, Khanna KK, Saunus JM, <\/span>Freire R<\/b>. DUB3 and USP7 de-ubquitination enzymes control replication inhibitor Geminin: molecular characterization and association with breast cancer. <\/span>Oncogene<\/span><\/i>. 2017 Aug 17;36(33):4802-4809. DOI: 10.1038\/onc.2017.21<\/span><\/li>\n
            • Cabrera E, Raninga P, Khanna KK, <\/span>Freire R<\/b>. GSK3-\u03b2 Stimulates Claspin Degradation via \u03b2-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival. <\/span>Cancers (Basel)<\/span><\/i>. 2019 Jul;11(8):1073. DOI: 10.3390\/cancers11081073<\/span><\/li>\n<\/ul>\n

               <\/p>\n<\/div>\n

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              [vc_row][vc_column][vc_column_text] Estr\u00e9s replicativo y tumorog\u00e9nesis Investigador responsable Raimundo Freire Betancor, PhD Investigador contratado del SCS\/FIISC; Unidad de Investigaci\u00f3n, HUC Investigadores doctores Gregoire Quinet, PhD (investigador postdoctoral, Fundaci\u00f3n Canaria Instituto de Investigaci\u00f3n Sanitaria de Canarias, FIISC) Estudiantes de doctorado e investigadores en formaci\u00f3n Esperanza Hern\u00e1ndez Carralero (Programa de Doctorado Ciencias de la Salud ULL. Beca Agencia…<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/template-no-title.php","meta":[],"_links":{"self":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/pages\/257"}],"collection":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/comments?post=257"}],"version-history":[{"count":4,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/pages\/257\/revisions"}],"predecessor-version":[{"id":590,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/pages\/257\/revisions\/590"}],"wp:attachment":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/media?parent=257"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}