{"id":271,"date":"2021-03-11T11:41:13","date_gmt":"2021-03-11T11:41:13","guid":{"rendered":"http:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/?page_id=271"},"modified":"2024-09-11T13:41:03","modified_gmt":"2024-09-11T13:41:03","slug":"modelos-animales-en-neurodegeneracion","status":"publish","type":"page","link":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/modelos-animales-en-neurodegeneracion\/","title":{"rendered":"Modelos animales en neurodegeneraci\u00f3n"},"content":{"rendered":"<p>[vc_row][vc_column][vc_column_text]<\/p>\n<div class=\"page-header\">\n<h1>Modelos animales en neurodegeneraci\u00f3n<\/h1>\n<\/div>\n<div class=\"content\">\n<h4><b>Investigador responsable<\/b><\/h4>\n<table class=\"jefe\">\n<tbody>\n<tr>\n<td class=\"provisional\"><\/td>\n<td><strong><a href=\"https:\/\/portalciencia.ull.es\/investigadores\/205538\/detalle\" target=\"_blank\" rel=\"noopener\" target=\"_blank\" rel=\"noopener\">Abraham Acevedo Arozena<\/a>, PhD<\/strong><\/p>\n<p>Investigador \u00abMiguel Servet tipo II\u00bb, SCS\/FIISC, Unidad de Investigaci\u00f3n, HUC<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><b>Investigadores colaboradores doctores<\/b><\/p>\n<ul>\n<li aria-level=\"1\"><span style=\"font-weight: 400;\">Jos\u00e9 Miguel Brito Armas, PhD (investigador CIBERNED)<\/span><\/li>\n<li aria-level=\"1\"><span style=\"font-weight: 400;\">Judith Noda Mayor, PhD (investigadora contratada, Fundaci\u00f3n BIOAVANCE) <\/span><span style=\"font-weight: 400;\">\ud83e\udc6a<\/span> <a href=\"https:\/\/portalciencia.ull.es\/investigadores\/278631\/detalle\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Enlace a Portal Ciencia ULL<\/span><\/a><\/li>\n<li aria-level=\"1\"><span style=\"font-weight: 400;\">Lucas Taoro Gonz\u00e1lez, PhD (Programa \u00abSara Borrell\u00bb, ISCIII, 2022-2025) <\/span><span style=\"font-weight: 400;\">\ud83e\udc6a<\/span> <a href=\"https:\/\/portalciencia.ull.es\/investigadores\/81332\/detalle\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Enlace a Portal Ciencia ULL<\/span><\/a><\/li>\n<li aria-level=\"1\"><span style=\"font-weight: 400;\">Felipe Fumagallo Reading, PhD (Investigador Juan de la Cierva) <\/span><span style=\"font-weight: 400;\">\ud83e\udc6a<\/span> <a href=\"https:\/\/portalciencia.ull.es\/investigadores\/190441\/detalle\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Enlace a Portal Ciencia ULL<\/span><\/a><\/li>\n<\/ul>\n<p><b>Estudiantes de doctorado e investigadores en formaci\u00f3n<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ram\u00f3n A. Mu\u00f1oz de Bustillo Alfaro (Programa de Doctorado Ciencias de la Salud ULL, 2021-2025)<\/span><\/li>\n<\/ul>\n<p><b>L\u00edneas de investigaci\u00f3n<\/b><\/p>\n<p><span style=\"font-weight: 400;\">Nuestra l\u00ednea de investigaci\u00f3n se centra en identificar y elaborar nuevas v\u00edas gen\u00e9ticas involucradas en la neurodegeneraci\u00f3n, particularmente en la Esclerosis Lateral Amiotr\u00f3fica (ELA) y la demencia frontotemporal (FTD), a trav\u00e9s del desarrollo de nuevos modelos de ratones con enfermedades junto con material derivado de pacientes. Estos estudios se encuentran en el centro de una colaboraci\u00f3n m\u00e1s amplia con importantes laboratorios nacionales e internacionales, que incorpora una experiencia \u00fanica en disciplinas gen\u00e9ticas, bioqu\u00edmicas y de biolog\u00eda celular. El trabajo del grupo se centra en el desarrollo de nuevos modelos de rat\u00f3n de ALS\/FTD, con un enfoque particular en la biolog\u00eda de TDP-43, la prote\u00edna patol\u00f3gica clave involucrada en ALS. Sobre la base de estos enfoques estamos construyendo una amplia colaboraci\u00f3n internacional que incluye varios laboratorios de Europa y EE.UU., as\u00ed como de Espa\u00f1a. Adicionalmente, trabajamos con la mayor\u00eda de los grupos del ITB interesados \u200b\u200ben generar modelos murinos espec\u00edficos de enfermedades humanas, colaborando en el desarrollo de una nueva plataforma.<\/span><\/p>\n<p><b>Proyectos financiados<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Estudiando el papel central de la prote\u00edna TDP-43 en ELA y otras proteinopat\u00edas TDP-43 (PI20\/00422). IP: Abraham Acevedo. Instituto de Salud Carlos III (2021-2023, 123.420 \u20ac)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Papel de la localizaci\u00f3n citoplasm\u00e1tica de TDP-43 en la patogenia de la esclerosis lateral amiotr\u00f3fica y otras proteinopat\u00edas TDP-43 (ProID2021010082). IP: Abraham Acevedo. Agencia Canaria de Investigaci\u00f3n, Innovaci\u00f3n y Sociedad de la Informaci\u00f3n, ACIISI (2022-2023, 70.000 \u20ac)<\/span><\/li>\n<\/ul>\n<p><b>Publicaciones 2023<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fisher EMC , Greensmith L, Malaspina A, Fratta P, Hanna MG, Schiavo G, Isaacs AM, Orrell RW, Cunningham TJ, <\/span><b>Acevedo Arozena A<\/b><span style=\"font-weight: 400;\">. Opinion: more mouse models and more translation needed for ALS. <\/span><i><span style=\"font-weight: 400;\">Neurotherapeutics<\/span><\/i><span style=\"font-weight: 400;\">.\u00a0 2023 May 4;18(1):30. doi: 10.1186\/s13024-023-00619-2<\/span><\/li>\n<\/ul>\n<p><b>Otras publicaciones representativas de los \u00faltimos a\u00f1os<\/b><\/p>\n<ul>\n<li aria-level=\"1\"><span style=\"font-weight: 400;\">Devoy A, Price G, De Giorgio F, Bunton-Stasyshyn R, Thompson D, Gasco S, Allan A, Codner GF, Nair RR, Tibbit C, McLeod R, Ali Z, Noda J, Marrero-Gagliardi A, Brito-Armas JM, \u00d6zt\u00fcrk MM, Simon M, O&#8217;Neill E, Bryce-Smith S, Harrison J, Atkins G, Corrochano S, Stewart M, Teboul L, <\/span><b>Acevedo-Arozena A<\/b><span style=\"font-weight: 400;\">, Fisher EMC, Cunningham TJ. Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models. <\/span><i><span style=\"font-weight: 400;\">iScience<\/span><\/i><span style=\"font-weight: 400;\">. 2021 Nov;24(12):103463. DOI: 10.1016\/j.isci.2021.103463<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Fratta P, Sivakumar P, Humphrey J, Lo K, Ricketts T, Oliveira H, Brito-Armas JM, Kalmar B, Ule A, Yu Y, Birsa N, Bodo C, Collins T, Conicella AE, Mejia Maza A, Marrero-Gagliardi A, Stewart M, Mianne J, Corrochano S, Emmett W, Codner G, Groves M, Fukumura R, Gondo Y, Lythgoe M, Pauws E, Peskett E, Stanier P, Teboul L, Hallegger M, Calvo A, Chi\u00f2 A, Isaacs AM, Fawzi NL, Wang E, Housman DE, Baralle F, Greensmith L, Buratti E, Plagnol V, Fisher EM, <\/span><b>Acevedo-Arozena A<\/b><span style=\"font-weight: 400;\">. Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis. <\/span><i><span style=\"font-weight: 400;\">EMBO Journal<\/span><\/i><span style=\"font-weight: 400;\">. 2018 Jun;37(11). DOI: 10.15252\/embj.201798684<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Corrochano S, Blanco G, Williams D, Wettstein J, Simon M, Kumar S, Moir L, Agnew T, Stewart M, Landman A, Kotiadis VN, Duchen MR, Wackerhage H, Rubinsztein DC, Brown SDM, <\/span><b>Acevedo-Arozena A<\/b><span style=\"font-weight: 400;\">. A genetic modifier suggests that endurance exercise exacerbates Huntington&#8217;s disease. <\/span><i><span style=\"font-weight: 400;\">Hum Mol Genet<\/span><\/i><span style=\"font-weight: 400;\">. 2018 May;27(10):1723-1731. DOI: 10.1093\/hmg\/ddy077<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Joyce PI, Fratta P, Landman AS, McGoldrick P, Wackerhage H, Groves M, Busam BS, Galino J, Corrochano S, Beskina OA, Esapa C, Ryder E, Carter S, Stewart M, Codner G, Hilton H, Teboul L, Tucker J, Lionikas A, Estabel J, Ramirez-Solis R, White JK, Brandner S, Plagnol, V, Bennet DL, Abramov AY, Greensmith L, Fisher EM, <\/span><b>Acevedo-Arozena A<\/b><span style=\"font-weight: 400;\">. Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration. <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Deficiency+of+the+zinc+finger+protein+ZFP106+causes+motor+and+sensory+neurodegeneration\" target=\"_blank\" rel=\"noopener\"><i><span style=\"font-weight: 400;\">Hum Mol Genet<\/span><\/i><span style=\"font-weight: 400;\">.<\/span><\/a><span style=\"font-weight: 400;\">\u00a02016 Jan;25(2):291-307. DOI: 10.1093\/hmg\/ddv471<\/span><\/li>\n<\/ul>\n<\/div>\n<p>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text] Modelos animales en neurodegeneraci\u00f3n Investigador responsable Abraham Acevedo Arozena, PhD Investigador \u00abMiguel Servet tipo II\u00bb, SCS\/FIISC, Unidad de Investigaci\u00f3n, HUC &nbsp; Investigadores colaboradores doctores Jos\u00e9 Miguel Brito Armas, PhD (investigador CIBERNED) Judith Noda Mayor, PhD (investigadora contratada, Fundaci\u00f3n BIOAVANCE) \ud83e\udc6a Enlace a Portal Ciencia ULL Lucas Taoro Gonz\u00e1lez, PhD (Programa \u00abSara Borrell\u00bb, ISCIII, 2022-2025)&#8230;<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/template-no-title.php","meta":[],"_links":{"self":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/pages\/271"}],"collection":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/comments?post=271"}],"version-history":[{"count":5,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/pages\/271\/revisions"}],"predecessor-version":[{"id":607,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/pages\/271\/revisions\/607"}],"wp:attachment":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/media?parent=271"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}