{"id":278,"date":"2021-03-11T11:52:24","date_gmt":"2021-03-11T11:52:24","guid":{"rendered":"http:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/?page_id=278"},"modified":"2026-07-08T12:19:48","modified_gmt":"2026-07-08T12:19:48","slug":"respuesta-inflamatoria-y-dano-tisular-en-la-artritis-reumatoide","status":"publish","type":"page","link":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/respuesta-inflamatoria-y-dano-tisular-en-la-artritis-reumatoide\/","title":{"rendered":"Respuesta inflamatoria y da\u00f1o tisular en la artritis reumatoide"},"content":{"rendered":"\n<div class=\"wp-block-stackable-columns alignfull stk-block-columns stk-block stk-49c10bb stk-block-background stk--has-background-overlay\" data-block-id=\"49c10bb\"><style>.stk-49c10bb {background-color:linear-gradient(135deg,rgb(161,9,157) 1%,rgb(63,37,132) 100%) !important;margin-top:-3% !important;margin-bottom:3% !important;}.stk-49c10bb:before{background-image:linear-gradient(135deg,rgb(161,9,157) 1%,rgb(63,37,132) 100%) !important;}.stk-49c10bb-column{justify-content:center !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-49c10bb-column stk--flex alignfull\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-429e70e\" data-v=\"4\" data-block-id=\"429e70e\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-429e70e-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-429e70e-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-616317e\" id=\"respuesta-inflamatoria-y-dano-tisular-en-la-artritis-reumatoide\" data-block-id=\"616317e\"><style>.stk-616317e {align-items:center !important;display:flex !important;}.stk-616317e .stk-block-heading__text{color:#ffffff !important;font-weight:800 !important;}<\/style><h2 class=\"stk-block-heading__text has-text-color has-text-align-center\">Respuesta inflamatoria y da\u00f1o tisular en la artritis reumatoide<\/h2><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-8b59b96\" data-block-id=\"8b59b96\"><style>.stk-8b59b96 .stk--block-align-8b59b96{align-items:flex-start !important;}.stk-8b59b96 {margin-top:25px !important;}.stk-8b59b96-column{--stk-columns-spacing:0px !important;--stk-column-gap:50px !important;}@media screen and (max-width: 767px){.stk-8b59b96-column{row-gap:var(--stk--preset--spacing--60, 2.25rem) !important;}}<\/style><div class=\"stk-row stk-inner-blocks stk--block-align-8b59b96 stk-block-content stk-content-align stk-8b59b96-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-dbb7e15\" data-v=\"4\" data-block-id=\"dbb7e15\"><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-dbb7e15-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-dbb7e15-inner-blocks\">\n<h4 class=\"wp-block-heading\"><strong>Investigador responsable<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><a href=\"https:\/\/portalciencia.ull.es\/investigadores\/81156\/detalle\" target=\"_blank\" rel=\"noreferrer noopener\" target=\"_blank\" rel=\"noopener\">Jos\u00e9 Federico D\u00edaz Gonz\u00e1lez<\/a>, MD, PhD<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Catedr\u00e1tico de Medicina; Departamento de Medicina Interna, Dermatolog\u00eda y Psiquiatr\u00eda, ULL \u2013 Jefe del Servicio de Reumatolog\u00eda, HUC<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Colaboradores doctores<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Javier Rafael Castro Hern\u00e1ndez, PhD (Profesor Ayudante Doctor; Departamento de Medicina F\u00edsica y Farmacolog\u00eda, ULL \u2013 hasta 05\/2023)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Colaboradores doctores asistenciales<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Judith M\u00aa L\u00f3pez Fern\u00e1ndez, MD, PhD (M\u00e9dico Adjunto; Servicio de Endocrinolog\u00eda, HUC)<\/li>\n\n\n\n<li>Iv\u00e1n Ferraz Amaro, MD, PhD (M\u00e9dico Adjunto; Servicio de Reumatolog\u00eda, HUC)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Estudiantes de doctorado e investigadores en formaci\u00f3n<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Sergio Iv\u00e1n Santos Concepci\u00f3n (Programa de Doctorado Ciencias de la Salud ULL, FIISC, Sociedad Espa\u00f1ola de Reumatolog\u00eda)<\/li>\n\n\n\n<li>No\u00e9 Adal Brito Garc\u00eda (Programa de Doctorado Ciencias M\u00e9dicas y Farmac\u00e9uticas, Desarrollo y Calidad de Vida, ULL)<\/li>\n\n\n\n<li>Virginia Dom\u00ednguez Pimentel (Programa de Doctorado Ciencias de la Salud, ULL)<\/li>\n\n\n\n<li>Ana Bel\u00e9n Llanos Mart\u00edn (Programa de Doctorado Ciencias de la Salud ULL, tesis defendida 19\/05\/2023)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>L\u00edneas de investigaci\u00f3n<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Determinaci\u00f3n del papel de los radicales libres de oxigeno en la regulaci\u00f3n de las primeras etapas de la respuesta inflamatoria<\/li>\n\n\n\n<li>Estudio del efecto in vivo de sustancias con actividad anti-L-selectina en la migraci\u00f3n de neutr\u00f3filos<\/li>\n\n\n\n<li>Estudio del papel modulador de los receptores adren\u00e9rgico alfa 2 en la respuesta inflamatoria aguda<\/li>\n\n\n\n<li>La implicaci\u00f3n de citocinas y quimiocinas en la patogenia de la artritis reumatoide, la artropat\u00eda psori\u00e1sica y el s\u00edndrome de Sj\u00f6gren<\/li>\n\n\n\n<li>Estudio de la capacidad del tejido pancre\u00e1tico en la diferenciaci\u00f3n de las c\u00e9lulas madre adultas en c\u00e9lulas endocrinas pancre\u00e1ticas<\/li>\n\n\n\n<li>Modulaci\u00f3n de la respuesta inflamatoria aguda y cr\u00f3nica de los receptores LXR<\/li>\n\n\n\n<li>Actividad f\u00edsica en pacientes con enfermedades articulares cr\u00f3nicas. Relaci\u00f3n entre actividad cl\u00ednica y capacidad de movimiento. An\u00e1lisis de la actividad f\u00edsica en pacientes con artritis psori\u00e1sica<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Efecto de las citocinas y la respuesta inflamatoria sobre la resistencia a la insulina, el flujo de colesterol y PCSK9<\/li>\n\n\n\n<li>Adiposidad abdominal y composici\u00f3n corporal en pacientes con artritis reumatoide<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Proyectos financiados<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Regulation of fat inflammation in human obesity. Role of chemokine system and alpha2-adrenergic receptors in macrophage accumulation in adipose tissue (PI21\/00406). IP: Federico D\u00edaz. Instituto de Salud Carlos III (01\/2022 \u2013 12\/2024, 120.000 \u20ac)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Publicaciones 2023<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Montero-Pastor N, S\u00e1nchez-Costa JT, Guerra-Rodr\u00edguez M, S\u00e1nchez-Alonso F, Moriano C, Loricera J,\u00a0<strong>D\u00edaz-Gonz\u00e1lez F<\/strong>. Development of a web tool to calculate the cumulative dose of glucocorticoids.\u00a0<em>Reumatologia Clinica<\/em>. 2023;19(1):1-5. DOI: 10.1016\/J.REUMA.2022.04.004<\/li>\n\n\n\n<li>Michelsen B, \u00d8stergaard M, Nissen MJ, Ciurea A, M\u00f6ller B, \u00d8rnbjerg LM, et al. (<strong>D\u00edaz-Gonz\u00e1lez F)<\/strong>, Bustabad-Reyes S. Differences and similarities between the EULAR\/ASAS-EULAR and national recommendations for treatment of patients with psoriatic arthritis and axial spondyloarthritis across Europe.\u00a0<em>The Lancet Regional Health \u2013 Europe<\/em>. 2023 Oct;33:100706. DOI: 10.1016\/j.lanepe.2023.100706<\/li>\n\n\n\n<li>\u00c1lvaro-Gracia JM, Sanchez-Piedra C, Culqui D, Rosello R, Garcia-Dorta A, Campos C, Manrique-Arija S, Ruiz-Montesinos D, Ros-Vilamajo I, Rodr\u00edguez-Lozano C, Freire-Gonz\u00e1lez M, Caliz R, Bohorquez C, Mateo Soria L, Busquets N, Castrejon I, S\u00e1nchez-Alonso F, Gonz\u00e1lez-D\u00e1vila E,\u00a0<strong>Diaz-Gonzalez F<\/strong>. Effects of COVID-19 vaccination on disease activity in patients with rheumatoid arthritis and psoriatic arthritis on targeted therapy in the COVIDSER study.\u00a0<em>RMD open<\/em>. 2023 Mar;9(1):e002936. DOI: 10.1136\/rmdopen-2022-002936<\/li>\n\n\n\n<li>Torre Alonso JC, Almod\u00f3var Gonz\u00e1lez R, Montilla Morales C, Sanz Sanz J,\u00a0<strong>D\u00edaz Gonz\u00e1lez F<\/strong>, Pascual Alfonso E, Gratac\u00f3s J. Expert recommendations for the use of apremilast in psoriatic arthritis.\u00a0<em>Reumatologia Clinica<\/em>. 2023;19(1):34-44. DOI: 10.1016\/J.REUMA.2022.01.002<\/li>\n\n\n\n<li>Pombo-Su\u00e1rez M, Seoane-Mato D,\u00a0<strong>D\u00edaz-Gonz\u00e1lez F<\/strong>, S\u00e1nchez-Alonso F, S\u00e1nchez-Jare\u00f1o M, Cea-Calvo L, Castrej\u00f3n I. Four-years retention rate of golimumab administered after discontinuation of non-TNF inhibitors in patients with inflammatory rheumatic diseases.\u00a0<em>Advances in Rheumatology<\/em>. 2023 Jun 7;63(1):25. DOI: 10.1186\/s42358-023-00296-1<\/li>\n\n\n\n<li>Garc\u00eda-Gonz\u00e1lez M, G\u00f3mez-Bernal F, Quevedo-Abeledo JC, Fern\u00e1ndez-Cladera Y, Gonz\u00e1lez-Rivero AF, de Vera-Gonz\u00e1lez A, de la Rua-Figueroa I, L\u00f3pez-Mejias R,\u00a0<strong>D\u00edaz-Gonz\u00e1lez F<\/strong>, Gonz\u00e1lez-Gay M\u00c1, Ferraz-Amaro I. Full characterization of the three pathways of the complement system in patients with systemic lupus erythematosus.\u00a0<em>Frontiers in Immunology<\/em>. 2023 Apr 21:14:1167055. DOI: 10.3389\/fimmu.2023.1167055<\/li>\n\n\n\n<li>Garc\u00eda-Gonz\u00e1lez M, G\u00f3mez-Bernal F, Quevedo-Abeledo JC, Fern\u00e1ndez-Cladera Y, Gonz\u00e1lez-Rivero AF, L\u00f3pez-Mej\u00edas R,\u00a0<strong>D\u00edaz-Gonz\u00e1lez F<\/strong>, Gonz\u00e1lez-Gay M\u00c1, Ferraz-Amaro I. HDL Cholesterol Efflux and the Complement System Are Linked in Systemic Lupus Erythematosus.\u00a0<em>Journal of Clinical Medicine<\/em>. 2023;12(16). DOI: 10.3390\/jcm12165405<\/li>\n\n\n\n<li>Pombo-Su\u00e1rez M, Seoane-Mato D,\u00a0<strong>D\u00edaz-Gonz\u00e1lez F<\/strong>, Cea-Calvo L, S\u00e1nchez-Alonso F, S\u00e1nchez-Jare\u00f1o M, Jovani V, Garc\u00eda-Magall\u00f3n B, Mart\u00ednez-Gonz\u00e1lez O, Campos-Fern\u00e1ndez C, Manero J, D\u00edaz-Torne C, Boh\u00f3rquez C, Ros-Vilamaj\u00f3 I, P\u00e9rez-Vera Y, Castrej\u00f3n I. Long-term retention of golimumab treatment in clinical practice in a large cohort of patients with rheumatoid arthritis, axial spondyloarthritis and psoriatic arthritis.\u00a0<em>Musculoskeletal Care<\/em>. 2023 Mar;21(1):189-197. DOI: 10.1002\/msc.1684<\/li>\n\n\n\n<li><strong>D\u00edaz-Gonz\u00e1lez F<\/strong>, Hern\u00e1ndez-Hern\u00e1ndez MV. Rheumatoid arthritis.\u00a0<em>Medicina Clinica<\/em>. 2023 Dec 22;161(12):533-542. DOI: 10.1016\/j.medcli.2023.07.014<\/li>\n\n\n\n<li>Ferraz-Amaro I, Santos-Concepci\u00f3n S, Castro J, Hern\u00e1ndez-Hern\u00e1ndez MV, Tejera-Segura B, Luna C, Delgado-Fr\u00edas E,\u00a0<strong>D\u00edaz-Gonz\u00e1lez F<\/strong>. Tocilizumab-related hypertriglyceridemia is independent of key molecules regulating lipid metabolism.\u00a0<em>European Journal of Clinical Investigation<\/em>. 2023 Sep;53(9):e14006. DOI: 10.1111\/eci.14006<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Otras publicaciones representativas de los \u00faltimos a\u00f1os<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Dom%C3%ADnguez-Luis%20MJ%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30443903\" target=\"_blank\" rel=\"noreferrer noopener\" target=\"_blank\" rel=\"noopener\">Dom\u00ednguez-Luis MJ<\/a>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Armas-Gonz%C3%A1lez%20E%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30443903\" target=\"_blank\" rel=\"noreferrer noopener\" target=\"_blank\" rel=\"noopener\">Armas-Gonz\u00e1lez E<\/a>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Herrera-Garc%C3%ADa%20A%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30443903\" target=\"_blank\" rel=\"noreferrer noopener\" target=\"_blank\" rel=\"noopener\">Herrera-Garc\u00eda A<\/a>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Arce-Franco%20M%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30443903\" target=\"_blank\" rel=\"noreferrer noopener\" target=\"_blank\" rel=\"noopener\">Arce-Franco M<\/a>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Feria%20M%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30443903\" target=\"_blank\" rel=\"noreferrer noopener\" target=\"_blank\" rel=\"noopener\">Feria M<\/a>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Vicente-Manzanares%20M%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30443903\" target=\"_blank\" rel=\"noreferrer noopener\" target=\"_blank\" rel=\"noopener\">Vicente-Manzanares M<\/a>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Mart%C3%ADnez-Ruiz%20A%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30443903\" target=\"_blank\" rel=\"noreferrer noopener\" target=\"_blank\" rel=\"noopener\">Mart\u00ednez-Ruiz A<\/a>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=S%C3%A1nchez-Madrid%20F%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30443903\" target=\"_blank\" rel=\"noreferrer noopener\" target=\"_blank\" rel=\"noopener\">S\u00e1nchez-Madrid F<\/a>,\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=D%C3%ADaz-Gonz%C3%A1lez%20F%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=30443903\" target=\"_blank\" rel=\"noreferrer noopener\" target=\"_blank\" rel=\"noopener\"><strong>D\u00edaz-Gonz\u00e1lez F<\/strong><\/a>. L-selectin expression is regulated by CXCL8-induced reactive oxygen species produced during human neutrophil rolling.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=L-selectin+expression+is+regulated+by+CXCL8-induced+reactive+oxygen+species+produced+during+human+neutrophil+rolling\" target=\"_blank\" rel=\"noreferrer noopener\" target=\"_blank\" rel=\"noopener\"><em>Eur J Immunol<\/em>.<\/a>\u00a02019 Mar;49(3):386-397. DOI: 10.1002\/eji.201847710<\/li>\n\n\n\n<li>\u00c1lvaro-Gracia JM, Jover JA, Garc\u00eda-Vicu\u00f1a R, Carre\u00f1o L, Alonso A, Marsal S, Blanco F, Mart\u00ednez-Taboada VM, Taylor P, Mart\u00edn-Mart\u00edn C, DelaRosa O, Tagarro I,\u00a0<strong>D\u00edaz-Gonz\u00e1lez F.<\/strong>\u00a0Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis (Cx611): results of a multicentre, dose escalation, randomised, single-blind, placebo-controlled phase Ib\/IIa clinical trial.\u00a0<em>Ann Rheum Dis<\/em>. 2017 Jan;76(1):196-202. DOI: 10.1136\/annrheumdis-2015-208918<\/li>\n\n\n\n<li>Cutolo M, Myerson GE, Fleischmann RM, Liote F,\u00a0<strong>D\u00edaz-Gonz\u00e1lez F<\/strong>, Van den Bosch F, Mazo-Ortega H, Feist E, Shan K, Hu C, Stevens RM, Poder A. A phase III, randomized, controlled trial of Apremilast in patients with psoriatic arthritis: resilys of the PALACE 2 trial.\u00a0<em>J Rheumatol<\/em>. 2016 Sep;43(9):1724-34. DOI: 10.3899\/jrheum.151376<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Respuesta inflamatoria y da\u00f1o tisular en la artritis reumatoide Investigador responsable Jos\u00e9 Federico D\u00edaz Gonz\u00e1lez, MD, PhD Catedr\u00e1tico de Medicina; Departamento de Medicina Interna, Dermatolog\u00eda y Psiquiatr\u00eda, ULL \u2013 Jefe del Servicio de Reumatolog\u00eda, HUC Colaboradores doctores Colaboradores doctores asistenciales Estudiantes de doctorado e investigadores en formaci\u00f3n L\u00edneas de investigaci\u00f3n Proyectos financiados Publicaciones 2023 Otras&#8230;<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/template-frontpage.php","meta":{"footnotes":""},"class_list":["post-278","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/pages\/278","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/comments?post=278"}],"version-history":[{"count":6,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/pages\/278\/revisions"}],"predecessor-version":[{"id":1026,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/pages\/278\/revisions\/1026"}],"wp:attachment":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/media?parent=278"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}