{"id":520,"date":"2022-06-07T17:37:18","date_gmt":"2022-06-07T17:37:18","guid":{"rendered":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/?page_id=520"},"modified":"2024-09-11T13:39:05","modified_gmt":"2024-09-11T13:39:05","slug":"fisiopatologia-del-metabolismo-mineral","status":"publish","type":"page","link":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/fisiopatologia-del-metabolismo-mineral\/","title":{"rendered":"Fisiopatolog\u00eda del metabolismo mineral"},"content":{"rendered":"<div class=\"page-header\">\n<h1>Fisiopatolog\u00eda del metabolismo mineral<\/h1>\n<\/div>\n<div class=\"content\">\n<h4><b>Investigador responsable<\/b><\/h4>\n<table class=\"jefe\">\n<tbody>\n<tr>\n<td class=\"provisional\"><\/td>\n<td><span style=\"font-weight: 400;\"><strong>Javier Donate Correa, PhD<\/strong> <\/span><\/p>\n<p><span style=\"font-weight: 400;\">Contrato Miguel Servet. Instituto de Salud Carlos III, ISCIII, CP20\/00122<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><b>Colaboradores externos<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Manuel Jos\u00e9 Morales Gonz\u00e1lez (Jefe de Servicio de Oncolog\u00eda M\u00e9dica, HUNSC)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Carolina Hern\u00e1ndez Carballo (FEA Servicio de Medicina Interna, HUNSC)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Juan F. Navarro Gonz\u00e1lez (Jefe de Servicio de la Unidad de Investigaci\u00f3n, HUNSC)<\/span><\/li>\n<\/ul>\n<p><b>Estudiantes de doctorado e investigadores en formaci\u00f3n<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Ainhoa Gonz\u00e1lez Luis (Programa de Doctorado en Ciencias de la Salud ULL. Contrato PFIS-FI22\/00213, ISCIII)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rebeca Navarro Alonso (contratada Programa INVESTIGO 2023, Gobierno de Canarias)<\/span><\/li>\n<\/ul>\n<p><b>Personal t\u00e9cnico o de gesti\u00f3n<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Alberto Mart\u00edn Olivera (T\u00e9cnico de laboratorio , Instituto de Salud Carlos III, ISCIII, CP20\/00122)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Juan Diego Carlos Monz\u00f3n (T\u00e9cnico de laboratorio, Unidad de Investigaci\u00f3n HUNSC)<\/span><\/li>\n<\/ul>\n<p><b>L\u00edneas de investigaci\u00f3n<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><i><span style=\"font-weight: 400;\">Efectos de las alteraciones del metabolismo mineral en el desarrollo de la diabetes<\/span><\/i><span style=\"font-weight: 400;\">. Determinaci\u00f3n de los efectos derivados de las alteraciones del metabolismo del f\u00f3sforo y de sus reguladores en la funcionalidad de la c\u00e9lula beta pancre\u00e1tica.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><i><span style=\"font-weight: 400;\">Mecanismos inflamatorios mediados por las alteraciones del sistema FGF23\/Klotho en el paciente con enfermedad renal<\/span><\/i><span style=\"font-weight: 400;\">. Investigar los procesos pro-inflamatorios asociados al incremento de los niveles del factor de crecimiento fibrobl\u00e1stico 23 (FGF23) y al descenso de los de su co-recepotor Klotho en el paciente con enfermedad renal cr\u00f3nica.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><i><span style=\"font-weight: 400;\">Determinaci\u00f3n del posible efecto dual del FGF23 sobre la activaci\u00f3n de las v\u00edas Ras\/Raf\/MAPK y CN\/NFAT en el adenocarcinoma ductal pancre\u00e1tico<\/span><\/i><span style=\"font-weight: 400;\">. Investigar el posible papel del FGF23 en la activaci\u00f3n de v\u00edas de se\u00f1alizaci\u00f3n relacionadas con el desarrollo del PDAC.<\/span><\/li>\n<\/ul>\n<p><b>Proyectos financiados<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Implicaciones fisiopatol\u00f3gicas de los desajustes del factor de crecimiento fibrobl\u00e1stico 23 en el desarrollo de la diabetes (PI21\/01037). IP: Javier Donate Correa. Instituto de Salud Carlos III, ISCIII (01\/01\/2022 &#8211; 31\/12\/2024, 75.020 \u20ac)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mecanismos inflamatorios mediados por el factor de crecimiento fibrobl\u00e1stico 23 en el paciente con enfermedad renal (PIFIISC21\/08). IP: Javier Donate Correa. Fundaci\u00f3n Canaria Instituto de Investigaci\u00f3n Sanitaria de Canarias, FIISC (2022-2023, 22.185 \u20ac)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">El factor de crecimiento fibrobl\u00e1stico 23 (FGF23) y el proceso inflamatorio en el paciente renal (OA22\/107). IP: Javier Donate Correa y Carolina Hern\u00e1ndez Carballlo. MAPFRE Canarias (2022-2023, 20.000 \u20ac)<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Efecto dual del factor de crecimiento fibrobl\u00e1stico 23 sobre la activaci\u00f3n de las v\u00edas Ras\/Raf\/MAPK y CN\/NFAT en el adenocarcinoma ductal pancre\u00e1tico (OA23\/072). IP: Javier Donate Correa. Fundaci\u00f3n DISA (2023-2024, 25.000 \u20ac)<\/span><\/li>\n<\/ul>\n<p><b>Publicaciones 2023<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Donate-Correa J<\/b><span style=\"font-weight: 400;\">, Mart\u00edn-N\u00fa\u00f1ez E, Mora-Fern\u00e1ndez C, Gonz\u00e1lez-Luis A, Mart\u00edn-Olivera A, <\/span><b>Navarro-Gonz\u00e1lez JF<\/b><span style=\"font-weight: 400;\">. Association of Klotho with Coronary Artery Disease in Subjects with Type 2 Diabetes Mellitus and Preserved Kidney Function: A Case-Control Study. <\/span><i><span style=\"font-weight: 400;\">International Journal of Molecular Sciences<\/span><\/i><span style=\"font-weight: 400;\">. 2023 Aug 30;24(17):13456. DOI: 10.3390\/ijms241713456<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Donate-Correa J<\/b><span style=\"font-weight: 400;\">, Mart\u00edn-N\u00fa\u00f1ez E, Mora-Fern\u00e1ndez C, Gonz\u00e1lez-Luis A, Mart\u00edn-Olivera A, <\/span><b>Navarro-Gonz\u00e1lez JF<\/b><span style=\"font-weight: 400;\">. Associations between Inflammation, Hemoglobin Levels, and Coronary Artery Disease in Non-Albuminuric Subjects with and without Type 2 Diabetes Mellitus. <\/span><i><span style=\"font-weight: 400;\">International Journal of Molecular Sciences<\/span><\/i><span style=\"font-weight: 400;\">. 2023;24(18). 2023 Sep 15;24(18):14131. DOI: 10.3390\/ijms241814131<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mart\u00edn-Carro B, <\/span><b>Donate-Correa J<\/b><span style=\"font-weight: 400;\">, Fern\u00e1ndez-Villabrille S, Mart\u00edn-V\u00edrgala J, Panizo S, Carrillo-L\u00f3pez N, Mart\u00ednez-Arias L, <\/span><b>Navarro-Gonz\u00e1lez JF<\/b><span style=\"font-weight: 400;\">, Naves-D\u00edaz M, Fern\u00e1ndez-Mart\u00edn JL, Alonso-Montes C, Cannata-And\u00eda JB. Experimental Models to Study Diabetes Mellitus and Its Complications: Limitations and New Opportunities. <\/span><i><span style=\"font-weight: 400;\">International Journal of Molecular Sciences<\/span><\/i><span style=\"font-weight: 400;\">. 2023 Jun 18;24(12):10309. DOI: 10.3390\/ijms241210309<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Donate-Correa J<\/b><span style=\"font-weight: 400;\">, Mart\u00edn-N\u00fa\u00f1ez E, Martin-Olivera A, Mora-Fern\u00e1ndez C, <\/span><b>Tagua VG<\/b><span style=\"font-weight: 400;\">, Ferri CM, L\u00f3pez-Castillo \u00c1, Delgado-Molinos A, L\u00f3pez-Tarruella VC, Ar\u00e9valo-G\u00f3mez MA, P\u00e9rez-Delgado N, Gonz\u00e1lez-Luis A, <\/span><b>Navarro-Gonz\u00e1lez JF<\/b><span style=\"font-weight: 400;\">. Klotho inversely relates with carotid intima- media thickness in atherosclerotic patients with normal renal function (eGFR \u226560 mL\/min\/1.73m2): a proof-of-concept study. <\/span><i><span style=\"font-weight: 400;\">Frontiers in Endocrinology<\/span><\/i><span style=\"font-weight: 400;\">. 2023;14:1146012. DOI: <\/span><a href=\"https:\/\/doi.org\/10.3389%2Ffendo.2023.1146012\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">10.3389\/fendo.2023.1146012<\/span><\/a><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Donate-Correa J<\/b><span style=\"font-weight: 400;\">, Mart\u00edn-Carro B, Cannata-And\u00eda JB, Mora-Fern\u00e1ndez C, <\/span><b>Navarro-Gonz\u00e1lez JF<\/b><span style=\"font-weight: 400;\">. Klotho, Oxidative Stress, and Mitochondrial Damage in Kidney Disease. <\/span><i><span style=\"font-weight: 400;\">Antioxidants<\/span><\/i><span style=\"font-weight: 400;\">. 2023 Jan 20;12(2):239. DOI: 10.3390\/antiox12020239<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mart\u00edn-Carro B, Mart\u00edn-V\u00edrgala J, Fern\u00e1ndez-Villabrille S, Fern\u00e1ndez-Fern\u00e1ndez A, P\u00e9rez-Basterrechea M, <\/span><b>Navarro-Gonz\u00e1lez JF<\/b><span style=\"font-weight: 400;\">, <\/span><b>Donate-Correa\u00a0 J<\/b><span style=\"font-weight: 400;\">, Mora-Fern\u00e1ndez C, Dusso AS, Carrillo-L\u00f3pez, N, Panizo S, Naves-D\u00edaz M, Fern\u00e1ndez-Mart\u00edn JL, Cannata-And\u00eda JB, Alonso-Montes C. Role of Klotho and AGE\/RAGE-Wnt\/\u03b2-Catenin Signalling Pathway on the Development of Cardiac and Renal Fibrosis in Diabetes. <\/span><i><span style=\"font-weight: 400;\">International Journal of Molecular Sciences<\/span><\/i><span style=\"font-weight: 400;\">. 2023;24(6). DOI: 10.3390\/IJMS24065241<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rayego-Mateos S, Rodrigues-Diez RR, Fernandez-Fernandez B, Mora-Fern\u00e1ndez C, Marchant V, <\/span><b>Donate-Correa J<\/b><span style=\"font-weight: 400;\">, <\/span><b>Navarro-Gonz\u00e1lez JF<\/b><span style=\"font-weight: 400;\">, Ortiz A, Ruiz-Ortega M. Targeting inflammation to treat diabetic kidney disease: the road to 2030. <\/span><i><span style=\"font-weight: 400;\">Kidney International<\/span><\/i><span style=\"font-weight: 400;\">. 2023;103(2):282-96. DOI: 10.1016\/J.KINT.2022.10.030<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Donate-Correa J<\/b><span style=\"font-weight: 400;\">, Matos-Perdomo E, Gonz\u00e1lez-Luis A, Mart\u00edn-Olivera A, Ortiz A, Mora-Fern\u00e1ndez C, <\/span><b>Navarro-Gonz\u00e1lez JF<\/b><span style=\"font-weight: 400;\">. The Value of Klotho in Kidney Transplantation. <\/span><i><span style=\"font-weight: 400;\">Transplantation<\/span><\/i><span style=\"font-weight: 400;\">. 2023;107(3):616-27. DOI: 10.1097\/TP.0000000000004331<\/span><\/li>\n<\/ul>\n<p><b>Otras publicaciones representativas de los \u00faltimos a\u00f1os<\/b><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mart\u00edn-N\u00fa\u00f1ez E, <\/span><b>Donate-Correa J<\/b><span style=\"font-weight: 400;\">, Ferri C, L\u00f3pez-Castillo A, Delgado-Molinos A, Hern\u00e1ndez-Carballo C, P\u00e9rez-Delgado N, Rodr\u00edguez-Ramos S, Cerro-L\u00f3pez P, <\/span><b>Tagua VG<\/b><span style=\"font-weight: 400;\">, Mora-Fern\u00e1ndez C, <\/span><b>Navarro-Gonz\u00e1lez JF<\/b><span style=\"font-weight: 400;\">. Association between serum levels of Klotho and inflammatory cytokines in cardiovascular disease: A case-control Study. <\/span><i><span style=\"font-weight: 400;\">Aging<\/span><\/i><span style=\"font-weight: 400;\">. 2020 Jan;12(2):1952-1964. DOI: 10.18632\/aging.102734<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Donate-Correa J<\/b><span style=\"font-weight: 400;\">, Ferri CM, Mart\u00edn-N\u00fa\u00f1ez E, P\u00e9rez-Delgado N, Gonz\u00e1lez-Luis A, Mora-Fern\u00e1ndez C, <\/span><b>Navarro-Gonz\u00e1lez JF<\/b><span style=\"font-weight: 400;\">. Klotho as a biomarker of subclinical atherosclerosis in patients with moderate to severe chronic kidney disease. <\/span><i><span style=\"font-weight: 400;\">Scientific Reports<\/span><\/i><span style=\"font-weight: 400;\">. 2021 Aug;11(1):15877. DOI: 10.1038\/s41598-021-95488-4<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><b>Donate-Correa J<\/b><span style=\"font-weight: 400;\">, Mart\u00edn-N\u00fa\u00f1ez E, Gonz\u00e1lez-Luis A, Ferri CM, Luis-Rodr\u00edguez D, <\/span><b>Tagua VG<\/b><span style=\"font-weight: 400;\">, Mora-Fern\u00e1ndez C, <\/span><b>Navarro-Gonz\u00e1lez JF<\/b><span style=\"font-weight: 400;\">. Pathophysiological implications of imbalances in fibroblast growth factor 23 in the development of diabetes. <\/span><i><span style=\"font-weight: 400;\">Journal of Clinical Medicine<\/span><\/i><span style=\"font-weight: 400;\">. 2021 Jun;10(12):2583. DOI: 10.3390\/jcm10122583<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Fisiopatolog\u00eda del metabolismo mineral Investigador responsable Javier Donate Correa, PhD Contrato Miguel Servet. Instituto de Salud Carlos III, ISCIII, CP20\/00122 &nbsp; Colaboradores externos Manuel Jos\u00e9 Morales Gonz\u00e1lez (Jefe de Servicio de Oncolog\u00eda M\u00e9dica, HUNSC) Carolina Hern\u00e1ndez Carballo (FEA Servicio de Medicina Interna, HUNSC) Juan F. Navarro Gonz\u00e1lez (Jefe de Servicio de la Unidad de Investigaci\u00f3n,&#8230;<\/p>\n","protected":false},"author":6,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/pages\/520"}],"collection":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/comments?post=520"}],"version-history":[{"count":3,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/pages\/520\/revisions"}],"predecessor-version":[{"id":606,"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/pages\/520\/revisions\/606"}],"wp:attachment":[{"href":"https:\/\/www.ull.es\/institutos\/instituto-tecnologias-biomedicas\/wp-json\/wp\/v2\/media?parent=520"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}