{"id":56394,"date":"2026-11-10T11:53:04","date_gmt":"2026-11-10T11:53:04","guid":{"rendered":"https:\/\/www.ull.es\/portal\/agenda\/?post_type=tribe_events&#038;p=56394"},"modified":"2026-11-10T11:53:04","modified_gmt":"2026-11-10T11:53:04","slug":"seminarios-del-itb-the-concerted-roles-of-atr-and-fanc-proteins-in-dna-replication-compensation-y-brca2-variant-functional-analysis-illuminates-genome-maintenance-defects-dr","status":"publish","type":"tribe_events","link":"https:\/\/www.ull.es\/portal\/agenda\/fr\/evento\/seminarios-del-itb-the-concerted-roles-of-atr-and-fanc-proteins-in-dna-replication-compensation-y-brca2-variant-functional-analysis-illuminates-genome-maintenance-defects-dr\/","title":{"rendered":"S\u00e9minaires de l&#039;ITB\u00a0: \u00ab\u00a0Les r\u00f4les concert\u00e9s des prot\u00e9ines ATR et FANC dans la compensation de la r\u00e9plication de l&#039;ADN\u00a0\u00bb et \u00ab\u00a0L&#039;analyse fonctionnelle des variants de BRCA2 met en lumi\u00e8re les d\u00e9fauts de maintenance du g\u00e9nome \u00e0 l&#039;origine de la tumorig\u00e9n\u00e8se\u00a0\u00bb"},"content":{"rendered":"<div>Le programme des s\u00e9minaires de recherche ITB 2026 se poursuit le jeudi 26 novembre, de 12h00 \u00e0 13h00, avec un double s\u00e9minaire pr\u00e9sent\u00e9 par le Dr St\u00e9phane Koundrioukoff, qui abordera le th\u00e8me \u00ab Les r\u00f4les concert\u00e9s des prot\u00e9ines ATR et FANC dans la compensation de la r\u00e9plication de l&#039;ADN \u00bb, et par le Dr Aura Carreira, qui pr\u00e9sentera le th\u00e8me \u00ab L&#039;analyse fonctionnelle des variants de BRCA2 met en lumi\u00e8re les d\u00e9fauts de maintenance du g\u00e9nome \u00e0 l&#039;origine de la tumorig\u00e9n\u00e8se \u00bb.<\/div>\n<div><\/div>\n<div>St\u00e9phane Koundrioukoff est chercheur au CNRS et responsable de la plateforme de peignage de l&#039;ADN. Il \u00e9tudie la dynamique chromosomique et ses travaux portent sur l&#039;analyse du stress de r\u00e9plication de l&#039;ADN, la caract\u00e9risation des sites fragiles chromosomiques et les m\u00e9canismes mol\u00e9culaires \u00e0 l&#039;origine de l&#039;instabilit\u00e9 g\u00e9nomique dans le cancer.<\/div>\n<div><\/div>\n<div>Aura Carreira est chercheuse principale au Centre de biologie mol\u00e9culaire Severo Ochoa (CBMSO, CSIC-UAM). Elle dirige le groupe de recherche sp\u00e9cialis\u00e9 dans la recombinaison homologue et la stabilit\u00e9 du g\u00e9nome. Ses travaux portent sur les m\u00e9canismes mol\u00e9culaires de la r\u00e9paration de l&#039;ADN, les fonctions biologiques du g\u00e8ne suppresseur de tumeur BRCA2 et les voies pathologiques li\u00e9es \u00e0 la pr\u00e9disposition et au d\u00e9veloppement des cancers h\u00e9r\u00e9ditaires du sein et de l&#039;ovaire.<\/div>\n<div><\/div>\n<div>Comme tous les s\u00e9minaires organis\u00e9s cette ann\u00e9e, en plus de se tenir en pr\u00e9sentiel dans la salle de s\u00e9minaire de l&#039;ITB, ils pourront \u00eatre suivis via les plateformes suivantes\u00a0: <a href=\"http:\/\/meet.google.com\/nzo-cqni-jdp\" target=\"_blank\" rel=\"noopener\">Lien Google Meet<\/a>.<\/div>","protected":false},"excerpt":{"rendered":"<p>El programa de Seminarios de Investigaci\u00f3n ITB 2026 contin\u00faa el jueves 26 de noviembre de 12:00 a 13:00 horas con un seminario doble por parte del Dr. St\u00e9phane Koundrioukoff, que&#8230;<\/p>","protected":false},"author":4,"featured_media":56395,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"_tribe_events_status":"","_tribe_events_status_reason":"","_tribe_events_is_hybrid":"","_tribe_events_is_virtual":"","_tribe_events_virtual_video_source":"","_tribe_events_virtual_embed_video":"","_tribe_events_virtual_linked_button_text":"","_tribe_events_virtual_linked_button":"","_tribe_events_virtual_show_embed_at":"","_tribe_events_virtual_show_embed_to":[],"_tribe_events_virtual_show_on_event":"","_tribe_events_virtual_show_on_views":"","_tribe_events_virtual_url":"","footnotes":""},"tags":[],"tribe_events_cat":[260,327],"class_list":["post-56394","tribe_events","type-tribe_events","status-publish","has-post-thumbnail","hentry","tribe_events_cat-facultad-de-ciencias-de-la-salud","tribe_events_cat-instituto-de-tecnologias-biomedicas","cat_facultad-de-ciencias-de-la-salud","cat_instituto-de-tecnologias-biomedicas"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ull.es\/portal\/agenda\/fr\/wp-json\/wp\/v2\/tribe_events\/56394","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ull.es\/portal\/agenda\/fr\/wp-json\/wp\/v2\/tribe_events"}],"about":[{"href":"https:\/\/www.ull.es\/portal\/agenda\/fr\/wp-json\/wp\/v2\/types\/tribe_events"}],"author":[{"embeddable":true,"href":"https:\/\/www.ull.es\/portal\/agenda\/fr\/wp-json\/wp\/v2\/users\/4"}],"version-history":[{"count":1,"href":"https:\/\/www.ull.es\/portal\/agenda\/fr\/wp-json\/wp\/v2\/tribe_events\/56394\/revisions"}],"predecessor-version":[{"id":56396,"href":"https:\/\/www.ull.es\/portal\/agenda\/fr\/wp-json\/wp\/v2\/tribe_events\/56394\/revisions\/56396"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ull.es\/portal\/agenda\/fr\/wp-json\/wp\/v2\/media\/56395"}],"wp:attachment":[{"href":"https:\/\/www.ull.es\/portal\/agenda\/fr\/wp-json\/wp\/v2\/media?parent=56394"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ull.es\/portal\/agenda\/fr\/wp-json\/wp\/v2\/tags?post=56394"},{"taxonomy":"tribe_events_cat","embeddable":true,"href":"https:\/\/www.ull.es\/portal\/agenda\/fr\/wp-json\/wp\/v2\/tribe_events_cat?post=56394"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}