{"id":9538,"date":"2024-08-02T11:36:08","date_gmt":"2024-08-02T09:36:08","guid":{"rendered":"https:\/\/www.ull.es\/portal\/noticias\/2024\/08\/02\/laguna-buenos-aires-nueva-tecnica-formacion-proteina\/"},"modified":"2026-10-28T09:37:16","modified_gmt":"2026-10-28T08:37:16","slug":"laguna-buenos-aires-nueva-tecnica-formacion-proteina","status":"publish","type":"post","link":"https:\/\/www.ull.es\/portal\/noticias\/en\/2024\/08\/02\/laguna-buenos-aires-nueva-tecnica-formacion-proteina\/","title":{"rendered":"Las universidades de La Laguna y Buenos Aires trabajan en una nueva t\u00e9cnica que estudia la formaci\u00f3n de la prote\u00edna"},"content":{"rendered":"

Researchers from the University of La Laguna and the University of Buenos Aires<\/a> They are currently working on the application of a technique that will allow significant progress in research on the proteins of cells that receive signals from groups of hormones, especially glucocorticoids, responsible for the human body being able to adapt to situations of physical and emotional stress.<\/p>\n

With the technique that both universities are perfecting and developing, it is possible to find out if the proteins inside cells are alone or associated one by one, two by two, three by three, and even four by four, since the way they group together can be "relevant" to their formation, according to the director of the Institute of Biomedical Technologies<\/a> and coordinator of the research group Pathophysiology of mineralocorticoids<\/a> from the University of La Laguna, Diego \u00c1lvarez de la Rosa Rodr\u00edguez<\/a>, and the researcher of Institute of Physiology, Molecular Biology and Neurosciences<\/a> from Argentina, Diego M. Presman<\/a>.<\/p>\n

\"Diego<\/a>

Diego \u00c1lvarez de la Rosa.<\/p><\/div>\n

The novelty of this microscopy technology, as the researcher from the Buenos Aires institution explains, lies in its ability to measure the protein within the cell itself. \u201cWhile other techniques of this type keep the cells immobile, this one allows us to apply it to living cells, making it possible to observe them while they perform their normal functions. This, in turn, allows us to add hormones to them to study how they react.\u201d.<\/p>\n

One of the observations derived from the line of research undertaken by \u00c1lvarez and Presman<\/a> This suggests that these proteins can mix in a controlled manner and cluster together within the same cell, a fact that complicates the process, since the effects of some hormones mix with those of others. "Why this happens, and in this way, is something about which very little is known, and it is partly due to the fact that they can associate," both experts indicate.<\/p>\n

The discovery of this novel finding, "which doesn't align with what has been published in biology textbooks for decades," as both researchers point out, was made possible by the use of these new techniques, in which Presman is a world-renowned expert. These procedures are also very useful in the development of new drugs because they allow researchers to verify whether cells are performing functions different from their usual ones. Understanding how cells react to these signals, or whether they change their biology and function, is fundamental in the case of cortisol.<\/p>\n

The hormone known as the stress hormone (glucocorticoids), essential for the body due to its regulatory role in metabolism, sleep, and immune function, among other vital functions, activates the protein on which both academic centers have focused their research. These hormones are \u201cvery important\u201d because there are drugs, commonly used to treat people, that mimic their function, such as some nonsteroidal anti-inflammatory drugs (NSAIDs).<\/p>\n

According to Presman, the first potent anti-inflammatory drug used against COVID-19 was one of these non-steroidal anti-inflammatory drugs (NSAIDs), which were able to significantly reduce mortality. \u201cThese are anti-inflammatory creams that, when they reach the cell, modify its function. What we are trying to do is understand in detail how this process occurs because, with a better understanding of the system, there are greater opportunities to manipulate it with other, even more effective drugs for controlling these types of reactions.\u201d.<\/p>\n

\"Diego<\/a>

Diego M. Presman.<\/p><\/div>\n

Training in microscopy techniques <\/strong><\/p>\n

The fact that observing live cells is much more complicated due to the quality of this technique, which requires very delicate equipment that needs many hours of training, is one of the reasons for the recent visit of Professor Diego Presman to the University of La Laguna, carried out within the framework of the program of aid for visiting professor stays aimed at the research staff financed by the Vice-Rectorate for Research and Transfer.<\/p>\n

Presman's stay has enabled doctoral students to learn firsthand about the use of these microscopy procedures, their refinement and new applications - fundamental to learning how to manipulate these proteins - as well as attending talks focused on the analysis of the movement of proteins in cells, evidence that until now had not been possible to visualize.<\/p>\n

The visit of the Argentine expert to the University of La Laguna was completed with the collection of data from the cells in the laboratory of the Institute of Biomedical Technologies, their subsequent numerical analysis through the application of specific programs and the training given to the students on the processing of the data obtained.<\/p>","protected":false},"excerpt":{"rendered":"

Investigadores de la Universidad de La Laguna y la Universidad de Buenos Aires trabajan actualmente en la aplicaci\u00f3n de una…<\/p>","protected":false},"author":15,"featured_media":9542,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[6,366,76,37,10],"tags":[3329,4061,2599,4062,4063],"class_list":["post-9538","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-destacado","category-instituto-universitario-de-tecnologias-biomedicas","category-institutos-universitarios","category-investigacion","category-portada-ull","tag-diego-alvarez-de-la-rosa","tag-diego-presman","tag-instituto-de-tecnologias-biomedicas","tag-proteina","tag-universidad-de-buenos-aires"],"acf":[],"primary_category":null,"featured_image_thumbnail_url":"https:\/\/www.ull.es\/portal\/noticias\/wp-content\/uploads\/sites\/2\/2026\/10\/Diego-M.-Presman-01-300x200.jpg","_links":{"self":[{"href":"https:\/\/www.ull.es\/portal\/noticias\/en\/wp-json\/wp\/v2\/posts\/9538","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ull.es\/portal\/noticias\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ull.es\/portal\/noticias\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ull.es\/portal\/noticias\/en\/wp-json\/wp\/v2\/users\/15"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ull.es\/portal\/noticias\/en\/wp-json\/wp\/v2\/comments?post=9538"}],"version-history":[{"count":1,"href":"https:\/\/www.ull.es\/portal\/noticias\/en\/wp-json\/wp\/v2\/posts\/9538\/revisions"}],"predecessor-version":[{"id":9541,"href":"https:\/\/www.ull.es\/portal\/noticias\/en\/wp-json\/wp\/v2\/posts\/9538\/revisions\/9541"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ull.es\/portal\/noticias\/en\/wp-json\/wp\/v2\/media\/9542"}],"wp:attachment":[{"href":"https:\/\/www.ull.es\/portal\/noticias\/en\/wp-json\/wp\/v2\/media?parent=9538"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ull.es\/portal\/noticias\/en\/wp-json\/wp\/v2\/categories?post=9538"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ull.es\/portal\/noticias\/en\/wp-json\/wp\/v2\/tags?post=9538"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}