{"id":2259,"date":"2021-06-07T08:34:47","date_gmt":"2021-06-07T08:34:47","guid":{"rendered":"https:\/\/www.ull.es\/servicios\/otri\/?post_type=agustin&#038;p=2259"},"modified":"2021-06-07T11:03:39","modified_gmt":"2021-06-07T11:03:39","slug":"dent","status":"publish","type":"agustin","link":"https:\/\/www.ull.es\/servicios\/otc\/fr\/agustin-betancourt\/dent\/","title":{"rendered":"Diagnostic et traitement de la maladie de Dent. D\u00e9veloppement d&#039;une plateforme in vivo pour les essais pr\u00e9cliniques de m\u00e9dicaments et cr\u00e9ation d&#039;un outil de diagnostic g\u00e9n\u00e9tique bas\u00e9 sur le s\u00e9quen\u00e7age massif cibl\u00e9 de g\u00e8nes entiers. D&amp;T-DENT"},"content":{"rendered":"<h1>Diagnostic et traitement de la maladie de Dent. D\u00e9veloppement d&#039;une plateforme in vivo pour les essais pr\u00e9cliniques de m\u00e9dicaments et cr\u00e9ation d&#039;un outil de diagnostic g\u00e9n\u00e9tique bas\u00e9 sur le s\u00e9quen\u00e7age massif cibl\u00e9 de g\u00e8nes entiers. D&amp;T-DENT<\/h1>Ce projet propose une approche globale visant \u00e0 rem\u00e9dier au manque de traitement et \u00e0 am\u00e9liorer le diagnostic de la maladie de Dent, et sera d\u00e9velopp\u00e9 autour de trois objectifs principaux\u00a0: \r\n<ul><li>\r\nObjectif 1 : D\u00e9velopper un outil de diagnostic sp\u00e9cifique bas\u00e9 sur le s\u00e9quen\u00e7age massif cibl\u00e9 de g\u00e8nes entiers (WGTS) qui analyse simultan\u00e9ment les deux g\u00e8nes responsables de la maladie de Dent, y compris toutes les r\u00e9gions codantes ainsi que les r\u00e9gions r\u00e9gulatrices et les r\u00e9gions introniques profondes. \r\n<\/li>\r\n<li>\r\n Objectif 2. D\u00e9velopper un service de criblage de m\u00e9dicaments et de validation de tests utilisant la souris KI Clcn5-Val523del. Ce mod\u00e8le repr\u00e9sente l&#039;instrument id\u00e9al pour r\u00e9aliser l&#039;\u00e9valuation pr\u00e9clinique de m\u00e9dicaments d\u00e9j\u00e0 approuv\u00e9s pour une utilisation en pratique clinique (repositionnement de m\u00e9dicaments), tels que les chaperons pharmacologiques, ainsi que de nouvelles mol\u00e9cules susceptibles d&#039;interagir avec la prot\u00e9ine CIC-5 mutante. <\/li>\r\n\r\n<li>Objectif 3. D\u00e9veloppement de proc\u00e9dures et de processus de protection de la propri\u00e9t\u00e9 intellectuelle et\/ou de g\u00e9n\u00e9ration de brevets qui permettraient de consolider le transfert des r\u00e9sultats des objectifs 1 et 2 de la recherche clinique fondamentale, jusqu&#039;\u00e0 leur commercialisation au niveau mondial.\r\n<\/li><\/ul><hr><h3>\u00c9quipe ULL<\/h3><ul><li><a href='https:\/\/www.ull.es\/servicios\/otc\/fr\/directorio\/search\/?busqueda=Elena Ramos Trujillo' target='_blank'>Elena Ramos Trujillo<\/a><\/li><li><a href='https:\/\/www.ull.es\/servicios\/otc\/fr\/directorio\/search\/?busqueda=Agust\u00edn Valenzuela Fern\u00e1ndez' target='_blank'>Agust\u00edn Valenzuela Fern\u00e1ndez<\/a><\/li><li><a href='https:\/\/www.ull.es\/servicios\/otc\/fr\/directorio\/search\/?busqueda=Alexis Oliva Mart\u00edn' target='_blank'>Alexis Oliva Mart\u00edn<\/a><\/li><li><a href='https:\/\/www.ull.es\/servicios\/otc\/fr\/directorio\/search\/?busqueda=F\u00e9lix Claverie Mart\u00edn' target='_blank'>F\u00e9lix Claverie Mart\u00edn<\/a><\/li><li><a href='https:\/\/www.ull.es\/servicios\/otc\/fr\/directorio\/search\/?busqueda=Mar\u00eda  Isabel Luis Yanes' target='_blank'>Mar\u00eda Isabel Luis Yanes<\/a><\/li><\/ul>","protected":false},"featured_media":0,"template":"","inventor":[660],"cotitulares":[373],"areas-agustin":[440],"convocatoria-agustin":[632],"class_list":["post-2259","agustin","type-agustin","status-publish","hentry","inventor-elena-ramos-trujillo","cotitulares-biosigma-s-l","areas-agustin-biotecnologia-biomedicina-y-salud","convocatoria-agustin-632","palabras-clave-diagnostico","palabras-clave-enfermedad-de-dent","palabras-clave-enfermedad-rara","palabras-clave-ngs","palabras-clave-plataforma-in-vivo","palabras-clave-reposicionamiento-de-farmacos","palabras-clave-tratamiento"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.ull.es\/servicios\/otc\/fr\/wp-json\/wp\/v2\/agustin\/2259","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ull.es\/servicios\/otc\/fr\/wp-json\/wp\/v2\/agustin"}],"about":[{"href":"https:\/\/www.ull.es\/servicios\/otc\/fr\/wp-json\/wp\/v2\/types\/agustin"}],"version-history":[{"count":1,"href":"https:\/\/www.ull.es\/servicios\/otc\/fr\/wp-json\/wp\/v2\/agustin\/2259\/revisions"}],"predecessor-version":[{"id":2260,"href":"https:\/\/www.ull.es\/servicios\/otc\/fr\/wp-json\/wp\/v2\/agustin\/2259\/revisions\/2260"}],"wp:attachment":[{"href":"https:\/\/www.ull.es\/servicios\/otc\/fr\/wp-json\/wp\/v2\/media?parent=2259"}],"wp:term":[{"taxonomy":"inventor","embeddable":true,"href":"https:\/\/www.ull.es\/servicios\/otc\/fr\/wp-json\/wp\/v2\/inventor?post=2259"},{"taxonomy":"cotitulares","embeddable":true,"href":"https:\/\/www.ull.es\/servicios\/otc\/fr\/wp-json\/wp\/v2\/cotitulares?post=2259"},{"taxonomy":"areas-agustin","embeddable":true,"href":"https:\/\/www.ull.es\/servicios\/otc\/fr\/wp-json\/wp\/v2\/areas-agustin?post=2259"},{"taxonomy":"convocatoria-agustin","embeddable":true,"href":"https:\/\/www.ull.es\/servicios\/otc\/fr\/wp-json\/wp\/v2\/convocatoria-agustin?post=2259"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}