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Marine Natural Products
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Group Leader Prof. Manuel Norte norte.jpg
Telephone: +34-922318586
mnorte@ull.es
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Dr. Manuel Norte has a degree in chemistry from the University of La Laguna, where he received his doctorate in 1976 under the supervision of Dr A. G. Gonzalez and Dr. J.D. Martin, related with metabolites produced by brown alga their biogenesis. Later his research was oriented towards the metabolites produced by red algae of the genus Laurencia, polyhalogenated sesquiterpenes and polyketides with structural and biological interest. In 1983 he moved to the University of Rhode Island (USA) to join the group of Prof. Y. Shimizu, to be involved in the biosynthesis of toxins responsible for PSP (Paralytic Shellfish Poisoning)red tides. On his return to La Laguna in 1984, he continues to work on bioactive substances of marine macro-organisms (algae, sponges, sea fans etc ..) and launches a new line of research on toxin-producing dinoflagellates. Prorocentrum genus, head of another group of red tides toxins producing, the DSP (Diarrhetic Shellfish Poisoning), was chosen. These dinoflagellates are characterized by the production of polyethers responsible for severe gastroentritis in contaminated seafood consumers. Therefore, the study has great economic and public health interest. Our aim was to search for new toxins and the of study their biosynthesis. As a result, between 1991 and 1993 he was part of the expert committee of BCR (Community Reference Bureau) of the European Union to produce toxins patterns and establish european monitoring networks in shellfish contaminated by red tides. Currently, he is the coordinator of the ULL research group on Marine Natural Products. This group is one of 19 participating in MAREX, a cooperative European marine biotechnology macro project funded by the 7th Framework Programme for finding new substances with pharmacological marine, agricultural, food etc ... applications. In the fields of their specialty he has published numerous articles in journals of international prestige and its current lines of work include the isolation and identification of polyether produced by dinoflagellates, their biosynthesis and mode of action. Also, his last work was carried out with polyketides from dinoflagellates and C-15 acetogenines from red algae as well as the development of new NMR methodologies.

Researcher Prof. José Javier Fernández Castro javi2.jpg
Telephone: +34-922318587
jjfercas@ull.es
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José J. Fernández was born in La Palma, Spain, in 1961 and read Pharmacy at the Universidad de La Laguna (BSc in 1982). He received his PhD in the Organic Chemistry Department at the same University in 1987 under the supervision of Professors J. D. Martin and M. Norte. He became an Assistant Professor at the Universidad de La Laguna in 1989, Associate Professor in 1994, and Professor in 1997. His research has been focused on the study of marine natural products with biological activity, especially in the isolation, structural determination, synthesis, structure-activity relationships and modes of action.  In recent years his interest has derived to marine polyether toxins, which includes aspects such as large-scale culture of microorganisms and biosynthetic studies with stable isotopes. He co-authored over one hundred publications.

Researcher Dr. María Luisa Souto luisasouto.png
Telephone: +34-922318587
msouto@ull.edu.es
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María Luisa Souto obtained her degree in Chemistry (1992) from the University of La Laguna where she completed her PhD in Organic Chemistry under the guidance of Professor Manuel Norte and Professor José J. Fernández. Her research was focused on the isolation and identification of metabolites from red alga Laurencia with potential pharmaceutical uses and she also investigated the biosynthesis of DSP toxins (Diarrhetic Shellfish Poisoning). As result, her thesis received the Extraordinary Doctoral Award of University of La Laguna (1996). Between 1997 and 1999, she was a postdoctoral fellow at Columbia University (USA) under the supervision of Professor Koji Nakanishi where she worked on the mechanistic investigations of 11-cis–retinal isomerization in rhodopsin, upon light activation. This work succeeded in clarifying relative movements of the retinal and the opsin receptor throughout the visual transduction process. In 1999, she returned to La Laguna under the Postdoctoral Reintegration Programme (MEC, 3/1999-9/2001) and the Ramón y Cajal Programme (11/2001-11/2006). She obtained her permanent position at the Organic Chemistry Department in 2006. Her research focuses on the chemistry of the unique natural products of marine organisms.

Researcher Dr. José Adrián Gavín Sazatornil gavin.jpg
Telephone: +34-922316502 ext 8598
jgavin@ull.edu.es
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José A. Gavín graduated in chemistry from the University of Zaragoza in 1971. He later move to the University of Neuchâtel (Switzerland) where he did his doctoral thesis (1975), with a study of volatile components of oakmoss Evernia prunastri. On his return to Spain he joined the Institute of Organic Natural Products CSIC in La Laguna where he works on the structural determination of organic compounds. In 1983 he was promoted to Professor of Organic Chemistry at the University of La Laguna. In 1994 he moved for a year to the Centre de Biochimie Structurale , CBS, Montpellier (France ) where he works on NMR methodology . In 2012 he obtained the post of full Professor of Organic Chemistry at the University of La Laguna. His current areas of interest are the study of ligand-receptor interactions by NMR techniques , configurational analysis of natural products based on measurements of homo and heteronuclear J.

Researcher Dr. Ana R. Díaz Marrero ana.jpg
Telephone: +34-922318587
adiazmar@ull.edu.es
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Ana R. Díaz Marrero, PhD in Chemical Sciences from the University of La Laguna, with extensive experience in the field of marine natural products chemistry: structure, chemotaxonomic studies and biomedical applications. She held a postdoctoral fellowship at the University of British Columbia, Canada, developing interdisciplinary research in the search for potential drugs of extracts of macro- and marine microorganisms. From 2007 until 2012 he continued her research in the area of marine products chemistry at the Institute of Natural Products and Agrobiology of the CSIC. Since 2012, she is a researcher at the University Institute of Bio-Organic "Antonio González" (ULL). During this time, her research has focused on the discovery of new bioactive molecules of natural origin produced by marine microorganisms. Currently, as part of the Agustín de Betancourt Program, she is developing a project focused on the transference of R & D in collaboration with the company PharmaMar, for the discovery of antitumor compounds of marine origin. Her scientific trajectory is supported by 49 publications in journals of high impact in the area of investigation of the chemistry of the natural products and two chapters of book. Participation in 45 national and international congresses, and 16 research projects, with IP in one of them (MICINN, SAF2010-16858). Co-direction of a DEA, three Masters, and four doctoral theses. Her research career has been awarded with GEPRONAT 2012 Award (RSEQ - Royal Spanish Society of Chemistry) for young researchers in the area of Natural Products Chemistry.

PhD Student Mr. Humberto José Domínguez Rodríguez humberto.jpg
Telephone:
hdomrod@ull.es
WebPage
Humberto J. Domínguez Rodríguez se licenció en Farmacia en Diciembre de 2005 por la Universidad de La Laguna obteniendo el Premio Extraordinario de Licenciatura. En estos años ha compaginado sus estudios de doctorado con diversas titulaciones. En 2006 realizó el curso de Diplomado en Sanidad por la Escuela Nacional de Sanidad. En 2008 obtuvo el Diploma de Estudios Avanzados y el Máster en “Seguridad y Calidad de los Alimentos” por la Universidad de La Laguna. Posteriormente, en el año 2010, logró la Diplomatura en Óptica y Optometría por la UEM, y la Diplomatura en Nutrición Humana y Dietética en 2012 por la UAX. En 2006 estuvo contratado como Investigador asociado en el Proyecto de Investigación “Evaluación del Potencial Tóxico de las Microalgas Presentes en las Costas Canarias”. En 2008 obtiene la beca predoctoral FPU. En este periodo ha participado en diversos Proyectos de Investigación y cursos de formación. Es autor de varias publicaciones y ha participado en numerosos Congresos Nacionales e Internacionales.

PhD Student Ms. Caterina Rodríguez de Vera CRV2.jpg
Telephone: +34-922318587
crodrive@ull.edu.es
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Caterina Rodríguez de Vera was born in Granadilla de Abona, Tenerife (Canary Islands, Spain) in 1987. She earned her bachelor’s degree in Marine Sciences in 2010 (University of Las Palmas de Gran Canaria), specializing in Coastal Managment. She obtained the Extraordinary Degree Award of ULPGC and the Academic Excellence Award, recognition of the Canary Islands Education Departament. In 2011, she finished her Master studies in Biotechnology (University of La Laguna). Nowadays, she enjoys a scholarship granted by Ministry of Education, Culture and Sport of the Spanish Government to perform her PhD investigation in Biomedicine, under the supervision of Dr. Mª Luisa Souto, Prof. Javier Fernández and Prof. Manuel Norte. Since 2012 she has served like students representation on the board of IUBO-AG.

PhD Student Mr. Guillermo Díaz Crespín Sin título.png
Telephone: +34-922318587
guillermo.diaz@ues.edu.sv
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Guillermo Díaz Crespín wasborn in 1978 in San Salvador (El Salvador). He graduated in Chemistry from the University of El Salvador in 2001. In 2010, he obtained the M. Sc. in Chemistry from the Universityof La Laguna. He is currently doing a PhD in Chemistry and Chemical Engineering, under the supervision of Prof. M. Norte, Prof.J. Javier Fernández and Dr. Antonio M. H.Daranas. His current work focuses on Isolation and structural determination of bioactive molecules of marine origin.

PhD Student Mr. Adrian Santiago José Benítez adrian.jpg
Telephone: +34-922318587
ajsantbenit@gmail.com
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Adrian Santiago José Benítez was born in Gran Canaria (Canary Islands, Spain) in January 1988. He graduated in Pharmacy from the University of La Laguna in 2011, getting the Masters in Biotechnology from the same university a year later. He began his research training in the research group Marine Natural Products in 2010 with a grant of collaboration, where the study of marine toxin okadaic acid was addressed. After finishing the graduated, he started studying a post-grade, where he developed the Master's Thesis in the same research group, working with the alga Laurencia viridis. In 2012 he joined the Synthesis of Natural Product Laboratory in “Consejo Superior de InvestigacionesCientíficas”, which makes a stay of one year under the direction of Dr. Alicia Boto Castro. Currently working on her doctoral thesis under the direction of Dr. José Javier Fernández Castro and Antonio Hernández Daranas in the research group Marine Natural Products in the Institute of Bio-Organic Antonio González, based on the search for new chemical entities in organisms of marine origin, and structural and pharmacological corresponding to develop analysis biomedical and industrial applications. Currently he is co-author of two scientific publications. He has also participated in various acts of science, national and international conferences.

PhD Student Ms. Rosalía González Brito rosalia.jpg
Telephone: +34-922318587
rosaliagonzalezbr@gmail.com
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Rosalía González Brito was born in San Cristóbal de La Laguna (Canary Islands, Spain) in 1979. She received her B.Sc. in Pharmacy from the University of La Laguna (Spain) in 2012, whereby gain a prize for the best Health Sciences academic records of University of La Laguna. She obtained the M.Sc. in Chemical Research from the University of La Laguna in 2013, with the best academic record. In 2014, she received a FPU grant from the Spanish Ministerio de Educación, Cultura y Deporte (MECyD) and she is currently a Ph.D. student in Chemistry and Chemistry Engineering under the supervision of Dr. Manuel Norte Martín and Dr. Antonio Hernández Daranas. Since April 2014, she is Delegate of the Ph.D. students of the Organic Chemistry Department. Her work is focused in research of bioactive molecules from sources of marine origin and the study of marine microorganism cultures.

PhD Student Mr. Adrián Morales Amador adrian2.jpg
Telephone: +34-922318587
adrian_tf@hotmail.com
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Adrián Morales Amador was born in Tenerife (Canary Islands, Spain) in April of 1991. He received his B. Sc. in chemistry in La Laguna University in 2013, getting his M. Sc. one year later from the same University. He began his research career in the group Marine Natural Products during his dissertationabout the phytochemistry and biosynthesis of the marine polyether yessotoxin. Currently, he pursues a Ph. D. in Chemistry and Chemical Engineering, under the supervision of Prof. Manuel Norte and Dr.María L. Souto, investigating new chemical entities from marine organisms, from the isolation to structural and pharmacological analysis for the development of biomedical and industrial feasibilities.

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