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Synthesis of Bioactive Products
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Research

SYNTHESIS

Prins cyclization promoted by Iron (III) halides:

Silyl alkyne Prins cyclization:

Aza-Prins and alkyne aza-Prins cyclization:

Domino reaction ABB’:

Synthesis of eight- and nine membered cyclic ethers by tandem Nicholas reaction/ring-closing metathesis:

Stereocontrolled synthesis of 2,5-dialkyl pyrrolidines:

β-Hydroxy-γ-lactones as chiral building blocks for the enantioselective synthesis of marine natural products:

DESIGN

Theoretical study of reactivity of organic compounds and biological structure-activity relationship:

 

BIOLOGICAL EVALUATION

Modulation of drug lipophilicity by silicon protecting groups:

Halovinyl oxa- and aza-cycles:

β-Hydroxy-α,β-lactones:

Catalpol:

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