Chemistry and Bioactivity of Natural Product-Like Compounds

The main objective of our research group is the discovery and development of new molecular entities displaying anti-inflammatory, cardioprotective, antitumour, antibacterial or antiparasitic activities. The access to bioactive molecules is carried out through efficient strategies to chart biologically relevant regions in the chemical space. We use natural “Privileged Structures”, domino reactions to generate diverse molecular skeletons and molecular complexity following a ”Diversity Oriented Synthesis” approach, Diverted Total Synthesis, Chemomodulation of Bioactivies of lead compounds, and Molecular Modeling studies