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The research groups in Area 3 are responsible for studying the psychopathological and neurological aspects of patients with brain injuries or neurodegenerative diseases. They employ neuropsychological and neuromolecular methods (cell signaling), BOLD signal analysis, EEG signals, and non-invasive brain stimulation.
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Neurodegenerative diseases and cell signaling
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Applied Neuropsychology
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Applied Neuropsychology
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Behavioral and neurological bases of health risk and locus of control
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Neuronal, epigenetic, and psychological factors in development and parenthood
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Coordinators: María Josefa Rodrigo López (Professor of Developmental Psychology) and Inmaculada León Santana (Professor of Basic Psychology).
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Group members:
Immaculate Leon Santana
María Josefa Rodrigo López
Ivan Padron Gonzalez
Silvia Herrero Roldán
Fernanda Espinosa González
Enrique Calleja Castro
Interests
The group focuses its research on several topics. (1) The neurological, epigenetic, cognitive, and personality bases of maternal care. More specifically, we study cases of child neglect in which parents are unable to care for and protect the child to meet their physical, cognitive, and emotional needs. Child neglect has negative consequences for children's epigenetic, neurobiological, and psychological development. (2) The neurological bases of adolescent risk-taking in social contexts. We study groups of adolescents and young adults, as well as young adults under court-ordered measures, comparing brain measurements with a profile of behavioral measures. (3) The evaluation of evidence-based programs to promote positive parenting and the positive development of young people in families at psychosocial risk, in order to prevent child abuse and neglect.
Current lines of research:
- Epigenetic features associated with neglect and negligent care
- Neural and psychological characteristics associated with neglectful care
- The neural characteristics of early juvenile development and delinquent behavior
Techniques/Methods
- Epigenetic-wide association studies (EWAS)
- Magnetic resonance imaging
- Event-related potentials
Relevant publications:
- Rodrigo, MJ, León, I., García-Pentón, L., Hernández-Cabrera, JA, & Quiñones, I. (2020). Neglectful maternal caregiving involves altered brain volume in empathy-related areas. Development and psychopathology, 32(4), 1534-1543.
- León, I., Rodrigo, MJ, El-Deredy, W., Modroño, C., Hernández-Cabrera, JA, & Quiñones, I. (2019). Limbic-visual attenuation to crying faces underlies neglectful mothering. Scientific reports, 9(1), 1-9.
- Rodrigo, MJ, León, I., Góngora, D., Hernández-Cabrera, JA, Byrne, S., & Bobes, MA (2016). Inferior fronto-temporo-occipital connectivity: a missing link between maltreated girls and neglectful mothers. Social cognitive and affective neuroscience, 11(10), 1658-1665.
- Rodrigo, MJ, Padrón, I., De Vega, M., & Ferstl, EC (2014). Adolescents' risky decision-making activates neural networks related to social cognition and cognitive control processes. Frontiers in Human Neuroscience, 8, 60.
- Rodrigo, MJ, Padrón, I., de Vega, M., & Ferstl, E. (2018). Neural substrates of counterfactual emotions after risky decisions in late adolescents and young adults. Journal of research on adolescence, 28(1), 70-86.
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Cell signaling and neurodegenerative diseases
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Coordinator: Raquel Marín Cruzado (Professor of Medicine-Physiology). Herminia Calixta Pérez González (Professor of Medicine-Anatomy).
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Group members:
Raquel Marín Cruzado
Herminia Pérez González
Herminia Calixta Pérez
Miriam González Gómez (Contracted Professor with a PhD)
Catalina Valdés Baizábal (Contracted Researcher, Agustín de Betancourt Program)
Interests:
We are dedicated to characterizing the molecular mechanisms initiated in the neuronal membrane that trigger neuroprotective and neurotoxic signaling pathways associated with age-related neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and other synucleipathies. We have also investigated the importance of essential lipids, which play a crucial role in neuronal aging and contribute to aberrant protein aggregation and neurotoxicity in the most common dementia. We are also working on dietary interventions based on essential lipids (long-chain polyunsaturated fatty acids - LCPUFAs) synergistically with estrogen, which appear to rescue some of the neuropathological hallmarks associated with AD. Overall, our ultimate goal is to provide new tools for novel biomarkers and nutritional interventions to improve diagnostic accuracy, as well as complementary therapeutic approaches to intervene in the progression of these diseases.
Ongoing lines of research:
- Early neuronal events in the development of age-related neurodegenerative diseases
- Dietary interventions, particularly in women's brain health, to counteract the side effects of hormonal decline during menopause
Techniques/Methods:
- Proteomics, lipidomics
- Behavioral tests
- Immunochemistry, confocal and electron microscopy
Relevant publications:
1.- Marin et al., (2012) Estrogen receptors in lipid raft signaling complexes for neuroprotection. Front Biosci. 4: 1420-1433 (14 citations, IF: 3.6)
2.- Diaz et al. (2015) Biophysical Alterations in Lipid Rafts from Human Cerebral Cortex Associated with Increased BACE1/A beta PP Interaction in Early Stages of Alzheimer's Disease. Journal of Alzheimer's disease. 43: 1185-1198 (31 citations, IF: 3.9).
3.- Marin et al., (2017) Anomalies occurring in lipid profiles and protein distribution in frontal cortex lipid rafts in DLB reveal neurochemical traits partially shared by AD and PD. Neurobiology of Aging 49: 52-59 (Citations: 18; IF: 4.4)
4.- Marin and Diaz (2018) Estrogen Interactions With Lipid Rafts Related to Neuroprotection. Impact of Brain Aging and Menopause.
5.- Diaz et al., (2016) Hippocampal Lipid Homeostasis in APP/PS1 Mice is Modulated by a Complex Interplay Between Dietary DHA and Estrogens: Relevance for Alzheimer's Disease. Journal of Alzheimer's disease. 49: 459-481 (18 citations, IF: 3.9).
6.- Canerina-Amaro A, Pereda D, Diaz M, Rodriguez-Barreto D, Casañas-Sánchez V, Heffer M, Garcia-Esparcia P, Ferrer I, Puertas-Avendaño R, Marin R. (2019) Differential Aggregation and Phosphorylation of Alpha Synuclein in Membrane Compartments Associated With Parkinson Disease.Front Neurosci. 13:382. https://doi.org/10.3389/fnins.2019.00382
7.- Marin R, Fabelo N, Fernández-Echevarría C, Canerina-Amaro A, Rodríguez-Barreto D, Quinto-Alemany D, Mesa-Herrera F, Díaz M. (2016). Lipid Raft Alterations in Aged-Associated Neuropathologies. Curr Alzheimer Res. 13(9):973-84. https://doi.org/10.2174/1567205013666160314150017
8.- Mesa-Herrera F, Taoro-González L, Valdés-Baizabal C, Diaz M, Marín R. (2019) Lipid and Lipid Raft Alteration in Aging and Neurodegenerative Diseases: A Window for the Development of New Biomarkers. Int J Mol Sci. 4;20(15):3810. https://doi.org/10.3390/ijms20153810
9.- Torrealba E, Garcia-Morales P, Cejudo JC, Diaz M, Rodriguez-Esparragon F, Fabre O, Mesa-Herrera F, Marin R, Sanchez-Garcia F, Rodriguez-Perez A, Gramunt NJ (2019) In-Out-Test: A New Paradigm for Sorting the Wheat from the Chaff in Prodromal Alzheimer's Disease.Alzheimers Dis.;67(1):265-277. https://doi.org/10.3233/JAD-171007[/vc_column_text][/vc_tta_section][/vc_tta_accordion][/vc_column][/vc_row][vc_row full_width=»stretch_row» gap=»1″ equal_height=»yes» disable_element=»yes»][vc_column css_animation=»fadeInLeft» width=»1/3″ css=».vc_custom_1581084709591{padding-bottom: 7% !important;background-color: #eaeaea !important;}»][vc_column_text css_animation=»none»]
Applied Neuropsychology
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Coordinators: José Barroso Ribal (Professor of Psychobiology) and Antonieta Nieto Barco (Professor of Psychobiology).
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