The proposal of this monograph adopts a radical approach. Re-signified social innovation can be part of the solution for advancing gender equality in our societies. The goal is to generate progress that is unavoidable in the need to implement a transformative culture that goes beyond the mere completion of various actions that may seem disconnected. The triad of social innovation, intersectionality, and a gender approach is poised to become the accelerator of a transformation that enables the achievement of the different Sustainable Development Goals, rooted in a culture of radical collaboration and grounded in the deepest values of social justice, human rights, and future partnerships.