The rehabilitation and regeneration of the architectural heritage of Santa Cruz de Tenerife's historic center continues to demand the necessary attention from public and private institutions. Despite the actions, projects, and urban plans carried out in recent decades, not only are there significant buildings that are practically abandoned, but even entire neighborhoods in the city center remain in disrepair. The main objective of the Project is to implement a model based on the comprehensive urban regeneration of the Toscal neighborhood, a historic district of Santa Cruz de Tenerife, taking into account sustainable, environmental, tourism, artistic, and responsible aspects. To achieve this objective, the project begins with actions linked to the reflection and debate proposed by the lines of research developed by seven researchers, based on a multidisciplinary approach that incorporates different perspectives from various fields of knowledge. The aim is to examine how urban processes are approached, first studying existing urban planning models and models for the neighborhood. On the one hand, the project seeks to highlight the priorities of El Toscal, taking into account both residents and visitors, while maintaining a comprehensive vision for the revitalization of the city's historic center. On the other hand, it aims to boost tourism by creating a route showcasing architectural styles and landmarks, especially given the recent opening of the new Santa Cruz de Tenerife Cruise Terminal, with a capacity to serve 10,000 cruise passengers, very close to the neighborhood.