Principal Investigator
| Raimundo Freire Betancor, PhD
Contract Researcher at SCS/FIISC; Research Unit, HUC |
PhD researchers
- Gregoire Quinet, PhD (Postdoctoral Researcher, Canary Islands Health Research Institute Foundation, FIISC)
PhD students and researchers in training
- Esperanza Hernández Carralero (Doctoral Program in Health Sciences ULL. Grant from the Canary Agency for Research, Innovation and the Information Society, ACIISI, thesis defended 03/2023)
- Gara Rodríguez Torres (Doctoral Program in Health Sciences ULL, Canary Agency for Research, Innovation and Information Society Grant, ACIISI, 2021-2026)
- Alba Molina de Armas (Doctoral Program in Health Sciences, ULL. Contract with the Canary Islands Foundation for Health Research, FIISC)
- María Magurán Cardiel (Canary Islands Agency for Research, Innovation and Information Society Grant, ACIISI, 2021-2026)
Lines of research
- Study of new proteins that control DNA replication in human cells.
- Study of the expression of DNA replication proteins in cancer.
- Determination of ubiquitin hydrolases involved in the control of genomic instability in human cells.
Funded projects
- Post-translational modifications in the control of genome stability and their role in cancer and other pathologies (PID2019-109222RB-I00). IP: Raimundo Freire and Veronique Smits. Ministry of Science and Innovation (06/2020 – 05/2023, €278,300)
- Enzymatic control of genome integrity maintenance: molecular mechanisms and opportunities for cancer treatment (PID2022-139691OB-I00). PI: Raimundo Freire and Veronique Smits. Ministry of Science and Innovation (10/2023 – 09/2026, €400,000)
- Characterization of the ubiquitin hydrolase USP37 in genomic stability: opportunities for cancer treatment. PI: Gregorie Quinet. DISA Foundation (2023-2024, €25,000)
Publications 2023
- Hernández‐Carralero E, Cabrera E, Rodríguez‐Torres G, Hernández‐Reyes Y, Singh AN, Santa‐María C, Fernández‐Justel JM, Janssens RC, Marteijn JA, Evert BO, Mailand N, Gómez M, Ramadan K, Smits VAJ, Freire R. ATXN3 controls DNA replication and transcription by regulating chromatin structure. Nucleic acids research. 2023;51(11):5396-413. DOI: 10.1093/nar/gkad212
- Pajenda S, Gerges DA, Freire R, Wagner L, Hevesi Z, Aiad M, Eder M, Schmidt A, Winnicki W, Eskandary FA. Acute Kidney Injury and BK Polyomavirus in Urine Sediment Cells.. Int J Mol Sci. 2023 Dec 15;24(24):17511. doi:10.3390/ijms242417511
- Moro RN, Biswas U, Kharat SS, Duzanic FD, Das P, Stavrou M, Raso MC, Freire R, Chaudhuri AR, Sharan SK, Penengo L. Interferon restores replication fork stability and cell viability in BRCA-defective cells via ISG15. Nat Commun. 2023 Oct 2;14(1):6140. doi:10.1038/s41467-023-41801-w
- Barroso-Chinea P, Salas-Hernández J, Cruz-Muros I, López-Fernández J, Freire R, Afonso-Oramas D. Expression of RAD9B in the mesostriatal system of rats and humans: Overexpression in a 6-OHDA rat model of Parkinson's disease. Ann Anat. 2023 Oct;250:152135. doi:10.1016/j.aanat.2023.152135
Other representative publications from recent years
- Cabrera E, Hernández-Pérez S, Koundrioukoff S, Debatisse M, Kim D, Smolka MB, Freire R, Gillespie DA. PERK inhibits DNA replication during the Unfolded Protein Response via Claspin and Chk1. Oncogene. 2017 Feb 2;36(5):678-686. DOI: 10.1038/onc.2016.239
- Hernandez-Perez S, Cabrera E, E left, Lim M, Reid L, Lakhani SR, Khanna KK, Saunus JM, Freire R. DUB3 and USP7 de-ubquitination enzymes control replication inhibitor Geminin: molecular characterization and association with breast cancer. Oncogene. 2017 Aug 17;36(33):4802-4809. DOI: 10.1038/onc.2017.21
- Cabrera E, Raninga P, Khanna KK, Freire R. GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival. Cancers (Basel). 2019 Jul;11(8):1073. DOI: 10.3390/cancers11081073