Pathophysiology of mineral metabolism

Principal Investigator

External collaborators

• Manuel José Morales González (Head of the Medical Oncology Service, HUNSC)
• Carolina Hernández Carballo (FEA Internal Medicine Service, HUNSC)
• Juan F. Navarro González (Head of Service of the Research Unit, HUNSC)

PhD students and researchers in training

• Ainhoa González Luis (Doctoral Program in Health Sciences ULL. Contract PFIS-FI22/00213, ISCIII)
• Rebeca Navarro Alonso (hired by the INVESTIGO 2023 Program, Government of the Canary Islands)

Technical or management staff

• Alberto Martín Olivera (Laboratory Technician, Carlos III Health Institute, ISCIII, CP20/00122)
• Juan Diego Carlos Monzón (Laboratory Technician, HUNSC Research Unit)

Lines of research

• Effects of mineral metabolism disorders on the development of diabetes. Determination of the effects derived from alterations in phosphorus metabolism and its regulators on the functionality of the pancreatic beta cell.
• Inflammatory mechanisms mediated by alterations in the FGF23/Klotho system in patients with kidney disease. Investigate the pro-inflammatory processes associated with the increase in levels of fibroblast growth factor 23 (FGF23) and the decrease in those of its co-receptor Klotho in patients with chronic kidney disease.
• Determination of the possible dual effect of FGF23 on the activation of the Ras/Raf/MAPK and CN/NFAT pathways in pancreatic ductal adenocarcinoma. Investigate the possible role of FGF23 in the activation of signaling pathways related to PDAC development.

Funded projects

• Pathophysiological implications of fibroblast growth factor 23 imbalances in the development of diabetes (PI21/01037). PI: Javier Donate Correa. Carlos III Health Institute, ISCIII (01/01/2022 – 31/12/2024, €75,020)
• Inflammatory mechanisms mediated by fibroblast growth factor 23 in patients with kidney disease (PIFIISC21/08). PI: Javier Donate Correa. Canary Islands Foundation Institute of Health Research of the Canary Islands, FIISC (2022-2023, €22,185)
• Fibroblast growth factor 23 (FGF23) and the inflammatory process in renal patients (OA22/107). PI: Javier Donate Correa and Carolina Hernández Carballo. MAPFRE Canarias (2022-2023, €20,000)
• Dual effect of fibroblast growth factor 23 on the activation of the Ras/Raf/MAPK and CN/NFAT pathways in pancreatic ductal adenocarcinoma (OA23/072). PI: Javier Donate Correa. DISA Foundation (2023-2024, €25,000)

Publications 2023

• Donate-Correa J, Martín-Núñez E, Mora-Fernández C, González-Luis A, Martín-Olivera A, Navarro-González JF. Association of Klotho with Coronary Artery Disease in Subjects with Type 2 Diabetes Mellitus and Preserved Kidney Function: A Case-Control Study. International Journal of Molecular Sciences. 2023 Aug 30;24(17):13456. DOI: 10.3390/ijms241713456
• Donate-Correa J, Martín-Núñez E, Mora-Fernández C, González-Luis A, Martín-Olivera A, Navarro-González JF. Associations between Inflammation, Hemoglobin Levels, and Coronary Artery Disease in Non-Albuminuric Subjects with and without Type 2 Diabetes Mellitus. International Journal of Molecular Sciences. 2023;24(18). 2023 Sep 15;24(18):14131. DOI: 10.3390/ijms241814131
• Martín-Carro B, Donate-Correa J, Fernández-Villabrille S, Martín-Vírgala J, Panizo S, Carrillo-López N, Martínez-Arias L, Navarro-González JF, Naves-Díaz M, Fernández-Martín JL, Alonso-Montes C, Cannata-Andía JB. Experimental Models to Study Diabetes Mellitus and Its Complications: Limitations and New Opportunities. International Journal of Molecular Sciences. 2023 Jun 18;24(12):10309. DOI: 10.3390/ijms241210309
• Donate-Correa J, Martín-Núñez E, Martin-Olivera A, Mora-Fernández C, Tagua VG, Ferri CM, López-Castillo Á, Delgado-Molinos A, López-Tarruella VC, Arévalo-Gómez MA, Pérez-Delgado N, González-Luis A, Navarro-González JF. Klotho inversely relates with carotid intima-media thickness in atherosclerotic patients with normal renal function (eGFR ≥60 mL/min/1.73m2): a proof-of-concept study. Frontiers in Endocrinology. 2023;14:1146012. DOI: 10.3389/fendo.2023.1146012
• Donate-Correa J, Martín-Carro B, Cannata-Andía JB, Mora-Fernández C, Navarro-González JF. Klotho, Oxidative Stress, and Mitochondrial Damage in Kidney Disease. Antioxidants. 2023 Jan 20;12(2):239. DOI: 10.3390/antiox12020239
• Martín-Carro B, Martín-Vírgala J, Fernández-Villabrille S, Fernández-Fernández A, Pérez-Basterrechea M, Navarro-González JF, Donate-Correa J, Mora-Fernández C, Dusso AS, Carrillo-López, N, Panizo S, Naves-Díaz M, Fernández-Martín JL, Cannata-Andía JB, Alonso-Montes C. Role of Klotho and AGE/RAGE-Wnt/β-Catenin Signaling Pathway on the Development of Cardiac and Renal Fibrosis in Diabetes. International Journal of Molecular Sciences. 2023;24(6). DOI: 10.3390/IJMS24065241
• Rayego-Mateos S, Rodrigues-Diez RR, Fernandez-Fernandez B, Mora-Fernández C, Marchant V, Donate-Correa J, Navarro-González JF, Ortiz A, Ruiz-Ortega M. Targeting inflammation to treat diabetic kidney disease: the road to 2030. Kidney International. 2023;103(2):282-96. DOI: 10.1016/J.KINT.2022.10.030
• Donate-Correa J, Matos-Perdomo E, González-Luis A, Martín-Olivera A, Ortiz A, Mora-Fernández C, Navarro-González JF. The Value of Klotho in Kidney Transplantation. Transplantation. 2023;107(3):616-27. DOI: 10.1097/TP.0000000000004331

Other representative publications from recent years

• Martín-Núñez E, Donate-Correa J, Ferri C, López-Castillo A, Delgado-Molinos A, Hernández-Carballo C, Pérez-Delgado N, Rodríguez-Ramos S, Cerro-López P, Tagua VG, Mora-Fernández C, Navarro-González JF. Association between serum levels of Klotho and inflammatory cytokines in cardiovascular disease: A case-control study. Aging. 2020 Jan;12(2):1952-1964. DOI: 10.18632/aging.102734
• Donate-Correa J, Ferri CM, Martín-Núñez E, Pérez-Delgado N, González-Luis A, Mora-Fernández C, Navarro-González JF. Klotho as a biomarker of subclinical atherosclerosis in patients with moderate to severe chronic kidney disease. Scientific Reports. 2021 Aug;11(1):15877. DOI: 10.1038/s41598-021-95488-4
• Donate-Correa J, Martín-Núñez E, González-Luis A, Ferri CM, Luis-Rodríguez D, Tagua VG, Mora-Fernández C, Navarro-González JF. Pathophysiological implications of imbalances in fibroblast growth factor 23 in the development of diabetes. Journal of Clinical Medicine. 2021 Jun;10(12):2583. DOI: 10.3390/jcm10122583