Animal model development for the evaluation of bone and cartilage regeneration
The drug delivery systems lab has a broad experience on the development and validation of preclinical in vivo models. All protocols are stablished and supervised by the veterinarian member of the group and head of the animal care facility of the University. The research performed by the lab members is this field has led to the invention of a new preclinical model of osteoporosis to assess bone regeneration under disease conditions. Moreover, standard models of healthy bone and cartilage regeneration and diabetic mice are also studied.
Segredo-Morales E, García-García P, Reyes R, Pérez-Herrero E, Delgado A, Évora C. Bone regeneration in osteoporosis by delivery BMP-2 and PRGF from tetronic-alginate composite thermogel. Int J Pharm. 2018;543(1-2):160-168.
Diaz-Gomez L, García-González CA, Wang J, Yang F, Aznar-Cervantes S, Cenis JL, Reyes R, Delgado A, Évora C, Concheiro A, Alvarez-Lorenzo C. Biodegradable PCL/fibroin/hydroxyapatite porous scaffolds prepared by supercritical foaming for bone regeneration. Int J Pharm. 2017;527(1-2):115-125.
Del Rosario C, Rodríguez-Évora M, Reyes R, Delgado A, Évora C. BMP-2, PDGF-BB, and bone marrow mesenchymal cells in a macroporous β-TCP scaffold for critical-size bone defect repair in rats. Biomed Mater. 2015;10(4):045008.
Rodríguez-Evora M, Reyes R, Alvarez-Lorenzo C, Concheiro A, Delgado A, Evora C. Bone regeneration induced by an in situ gel-forming poloxamine, bone morphogenetic protein-2 system. J Biomed Nanotechnol. 2014;10(6):959-69.