Drug Delivery Systems

Preparation and characterization of micro/nanoparticulated systems for the controlled release of peptide and non-peptide drugs

The controlled release of therapeutic molecules is crucial for several clinical applications. The incorporation of such molecules in adequate nano and/or microparticulated systems allow to provide a prolonged release achieving the local concentration required for their therapeutic effect. Furthermore, nanoparticulated systems are highly versatile drug delivery platforms that not only allow high drug encapsulation efficiencies but also targeted release of their cargo. On this context, the Drug Delivery Systems lab is focused on the development of nano and/or microparticulated systems loaded with peptide and non-peptide drugs for efficient drug loading and moldable/targeted release profile. Using this approach, the research group has demonstrated the suitability of lipid nanoparticles for gene therapy and the successful application of growth factor loaded microspheres for bone tissue regeneration among other findings in this field. More recently, the lab research is also focused on targeted nanocarries for local treatment of cancer.

García-García P, Reyes R, Segredo-Morales E, Pérez-Herrero E, Delgado A, Évora C. PLGA-BMP-2 and PLA-17β-Estradiol Microspheres Reinforcing a Composite Hydrogel for Bone Regeneration in Osteoporosis. Pharmaceutics. 2018;11(12). pii:E648.

García-García P, Ruiz M, Reyes R, Delgado A, Évora C, Riancho JA, Rodríguez-Rey JC, Pérez-Campo FM. Smurf1 Silencing Using a LNA-ASOs/Lipid Nanoparticle System to Promote Bone Regeneration. Stem Cells Transl Med. 2019;8(12):1306-1317.