Principal Investigator

Collaborating researchers (PhDs)

• Víctor García Tagua, PhD (Assistant Professor; Department of Obstetrics and Gynecology, Pediatrics, Preventive Medicine and Public Health, Toxicology, Legal and Forensic Medicine and Parasitology, ULL) ? Link to ULL Science Portal

External collaborators and associated researchers

• Carmen Mora Fernández (FEA Responsible for scientific management and innovation, HUNSC Research Unit)
• Desirée Luis Rodríguez (FEA Nephrology Service, HUNSC)
• Victoria Castro López-Tarruella (FEA Pathology Service, HUNSC)
• Orlando Siverio Morales (FEA Nephrology Service, HUNSC)
• Rosa Pérez Morales (FEA Nephrology Service, HUNSC)
• Carlos Marín Delgado (FEA Nephrology Service, HUNSC)

PhD students and researchers in training

• Carla María Ferri (Doctoral Program in Health Sciences ULL, Canary Agency for Innovation, Research and Information Society, ACIISI, TESIS2018010110)

Technical or management staff

• Lisset González Burgos (Senior Technician, contracted for project RD21/0005/0013, ISCIII, HUNSC)

Lines of research

• Chronic kidney disease and its complications.
• Diabetic kidney disease.
• Implications of the inflammatory phenomenon in highly prevalent diseases.
• FGF23/Klotho system.

Funded projects

• FGF23/Klotho system in subclinical atherosclerotic vascular disease. Pathophysiological implications and therapeutic approach (PI19/00035). PI: Juan F. Navarro. Carlos III Health Institute (2020-2023, €56,870)
• RED RICORS2040 (KIDNEY DISEASE). RD21/0005/0013. IP: Juan F. Navarro. Carlos III Health Institute (2022-2024, €105,765)
• Detection of the Klotho protein using nanoantibodies obtained from Canary camelids (PIFIISC21/23). PIs: Carmen Mora Fernández and Víctor García Tagua. Canary Islands Foundation Institute of Health Research of the Canary Islands, FIISC (2022-2023, €27,000)

Publications 2023

• Donate-Correa J, Martín-Núñez E, Mora-Fernández C, González-Luis A, Martín-Olivera A, Navarro-González JF. Association of Klotho with Coronary Artery Disease in Subjects with Type 2 Diabetes Mellitus and Preserved Kidney Function: A Case-Control Study. International Journal of Molecular Sciences. 2023 Aug 30;24(17):13456. DOI: 10.3390/ijms241713456
• Donate-Correa J, Martín-Núñez E, Mora-Fernández C, González-Luis A, Martín-Olivera A, Navarro-González JF. Associations between Inflammation, Hemoglobin Levels, and Coronary Artery Disease in Non-Albuminuric Subjects with and without Type 2 Diabetes Mellitus. International Journal of Molecular Sciences. 2023;24(18). 2023 Sep 15;24(18):14131. DOI: 10.3390/ijms241814131
• Martín-Carro B, Donate-Correa J, Fernández-Villabrille S, Martín-Vírgala J, Panizo S, Carrillo-López N, Martínez-Arias L, Navarro-González JF, Naves-Díaz M, Fernández-Martín JL, Alonso-Montes C, Cannata-Andía JB. Experimental Models to Study Diabetes Mellitus and Its Complications: Limitations and New Opportunities. International Journal of Molecular Sciences. 2023 Jun 18;24(12):10309. DOI: 10.3390/ijms241210309
• Donate-Correa J, Martín-Núñez E, Martin-Olivera A, Mora-Fernández C, Tagua VG, Ferri CM, López-Castillo Á, Delgado-Molinos A, López-Tarruella VC, Arévalo-Gómez MA, Pérez-Delgado N, González-Luis A, Navarro-González JF. Klotho inversely relates with carotid intima-media thickness in atherosclerotic patients with normal renal function (eGFR ≥60 mL/min/1.73m2): a proof-of-concept study. Frontiers in Endocrinology. 2023;14:1146012. DOI: 10.3389/fendo.2023.1146012
• Donate-Correa J, Martín-Carro B, Cannata-Andía JB, Mora-Fernández C, Navarro-González JF. Klotho, Oxidative Stress, and Mitochondrial Damage in Kidney Disease. Antioxidants. 2023 Jan 20;12(2):239. DOI: 10.3390/antiox12020239
• Martín-Carro B, Martín-Vírgala J, Fernández-Villabrille S, Fernández-Fernández A, Pérez-Basterrechea M, Navarro-González JF, Donate-Correa J, Mora-Fernández C, Dusso AS, Carrillo-López, N, Panizo S, Naves-Díaz M, Fernández-Martín JL, Cannata-Andía JB, Alonso-Montes C. Role of Klotho and AGE/RAGE-Wnt/β-Catenin Signaling Pathway on the Development of Cardiac and Renal Fibrosis in Diabetes. International Journal of Molecular Sciences. 2023;24(6). DOI: 10.3390/IJMS24065241
• Rayego-Mateos S, Rodrigues-Diez RR, Fernandez-Fernandez B, Mora-Fernández C, Marchant V, Donate-Correa J, Navarro-González JF, Ortiz A, Ruiz-Ortega M. Targeting inflammation to treat diabetic kidney disease: the road to 2030. Kidney International. 2023;103(2):282-96. DOI: 10.1016/J.KINT.2022.10.030
• Donate-Correa J, Matos-Perdomo E, González-Luis A, Martín-Olivera A, Ortiz A, Mora-Fernández C, Navarro-González JF. The Value of Klotho in Kidney Transplantation. Transplantation. 2023;107(3):616-27. DOI: 10.1097/TP.0000000000004331
• Quiroga B, Ortiz A, Navarro-González JF, Santamaría R, de Sequera P, Díez J. From cardiorenal syndromes to cardionephrology: a reflection by nephrologists on renocardiac syndromes. Clin Kidney J. 2023,16:19-29. DOI: 10.1093/ckj/sfac113
• Ortiz A, del Arco Galán C, Fernández-García JC, Gómez Cerezo J, Ibán Ochoa R, Núñez J, Pita Gutiérrez F, Navarro González JF. Consensus document on the management of hyperkalemia. Nephrology. 2023;43(5):765-782. DOI: 10.1016/j.nefro.2023.05.004
• Mora-Fernández C, Pérez A, Mollar A, Palau P, Amiguet M, de la Espriella R, Sanchís J, Górriz JL, Soler MJ, Navarro-González JF, Núñez J. Short-term changes in Klotho and FGF23 in heart failure with reduced ejection fraction –a substudy of the DAPA-VO2 study. Front Cardiovasc Med. 2023;10:1242108. DOI: 10.3389/fcvm.2023.1242108
• Martín-Carro B, Navarro-González JF, Ortiz A, Zoccalli C, Floege J, Ferreira MA, Górriz-Teruel JL, Carrillo-López N, Panizo S, Locatelli F, Ketteler M, London GM, Naves-Díez M, Alonso-Montes C, Cannata-Andía JB, Fernández-Martín JL. Mineral and bone metabolism markers and mortality in diabetic patients on haemodialysis. Nephrol Dial Transplant. 2023,38:2589-2597. DOI: 10.1093/ndt/gfad122
• Aguilar A, Gifre L, Ureña-Torres P, Carrillo-López N, Rodríguez-García M, Massó E, da Silva I, López-Báez V, Sánchez-Bayá M, Prior-Español A, Urrutia M, Paul J, Bustos MC, Vila A, Garnica-León I, Navarro-González JF, Mateo L, Bover J. Pathophysiology of bone disease in chronic kidney disease: from basics to renal osteodystrophy and osteoporosis. Front Physiol. 2023,14:1177829. DOI: 10.3389/fphys.2023.1177829
• Martín-Vírgala J, Fernández Villabrille S, Martín Carro B, Tamargo Gómez I, Navarro-González JF, Mora-Fernández C, Calleros L, Astudillo Cortés E, Avello Llano N, Mariño G, Dusso AS, Alonso Montes C, Panizo S, Cannata-Andía JB, Naves Díaz M, Carrillo López N. Serum and urinary soluble α-klotho as markers of kidney and vascular impairment. Nutrients. 2023 Mar 18;15(6):1470. DOI: 10.3390/nu15061470
• Torregrosa JV, Bover J, Rodríguez Portillo M, González Parra E, Dolores Arenas M, Caravaca F, González Casaus ML, Martín-Malo A, Navarro-González JF, Lorenzo V, Molina P, Rodríguez M, Cannata Andia J. Recommendations of the Spanish Society of Nephrology for the management of mineral and bone metabolism disorders in patients with chronic kidney disease: 2021 (SEN-MM). Nephrology. 2023 Jun:43 Suppl 1:1-36. DOI: 10.1016/j.nefroe.2023.03.003

Representative publications from recent years

• Martín-Núñez E, Donate-Correa J, Kannengiesser C, De Brauwere DP, Leroy C, Oudin C, Friedlander G, Prieto-Morín C, Tagua VG, Ureña-Torres PA, Navarro-González JF. A novel heterozygous deletion variant in KLOTHO gene leading to haploinsufficiency and impairment of fibroblast growth factor 23 signaling pathway. J Clin Med. 2019 Apr;8(4). pii: E500. DOI: 10.3390/jcm8040500
• Navarro-González JF, Sánchez-Niño MD, Donate-Correa J, Martín-Núñez E, Ferri C, Pérez-Delgado N, Górriz JL, Martínez-Castelao A, Ortiz A, Mora-Fernández C. Effects of pentoxifylline on soluble Klotho concentrations and renal tubular cell expression in diabetic kidney disease. Diabetes Care. 2018 Aug;41(8):1817-1820. DOI: 10.2337/dc18-0078
• Donate-Correa J, Henriquez-Palop F, Martín-Núñez E, Pérez-Delgado N, Muros-de-Fuentes M, Mora-Fernandez C, Navarro-González JF. Effect of Paricalcitol on FGF-23 and Klotho in kidney transplant recipients. Transplantation. 2016;100(11):2432-2438. DOI: 10.1097/TP.0000000000001339