Principal Investigator

Collaborating researchers (PhDs)

• Itahisa Marcelino Rodríguez, PhD (Contracted Professor; Department of Obstetrics and Gynecology, Pediatrics, Preventive Medicine and Public Health, Toxicology, Legal and Forensic Medicine and Parasitology, ULL) ? Link to ULL Science Portal

External medical collaborators

• Laura Ciuffreda, PhD (Sara Borrell Program CD22/00138, ISCIII) 
• Julia Alcoba Florez, PhD (Head of Section of the Microbiology Unit, HUNSC)
• Ariel Callero Viera, PhD (Specialist Physician in Allergology, HUNSC)
• Victor García Olivares, PhD (Contract Researcher, ITER)
• Rafaela Gonzaléz Montelongo, PhD (Unit Manager, ITER)
• Aitana Alonso González, PhD (researcher Margarita Salas)

PhD students and researchers in training

• Alejandro Mendoza Álvarez (Doctoral Program in Medical and Pharmaceutical Sciences, Development and Quality of Life ULL. FPU Contract TESIS2020010002, contract OA17/008, thesis defended 30/06/2023)
• Héctor Rodríguez Pérez (Doctoral Program in Industrial, Computer and Environmental Engineering ULL, IMPaCT-iDATA project contract IMP/00019, thesis defended 22/12/2023)
• José M. Lorenzo Salazar (Doctoral Program in Health Sciences ULL, ITER)
• Adrián Muñoz Barrera (Predoctoral student, ITER)
• Luis A. Rubio Rodríguez (Pre-choral student, ITER)
• Ana Díaz de Usera (Contract ProID2021010084)
• Eva Tosco Herrera (Doctoral Program in Medical and Pharmaceutical Sciences, Development and Quality of Life ULL. FPU Contract TESIS2021010046)
• Eva Suárez Pajés (ULL Health Sciences Doctoral Program, ITER, 2021-2025. Contract FPU TESIS2022010042)
• David Jáspez Toledo (researcher, ITER)
• Melody del Pino Ramírez Falcón (Predoctoral student, contract project ERAPERMED2021-259_i-RECORDS)

Technical or management staff

• Almudena Corrales Moreno (Technical Support Staff, SCS/FIISC, HUNSC)
• Antonio Íñigo Campos (Technical Support Staff, ITER)

Lines of research

1. Early diagnosis and our therapeutic strategies in critical care patients:

– Genetic predisposition: large-scale association studies (GWAS and exome studies).

– Lung microbiome as prognostic biomarkers. 

1. Early diagnosis and genetic factors involved in immunologically based diseases (using GWAS, exome and whole genome analyses):

– Study of association with susceptibility and survival.

– Studies of association with treatment response.

– Medical sequencing (hereditary angioedema, idiopathic pulmonary fibrosis).

– Metagenomic analyses.

– Genomic analysis of infectious agents. 

1. Lines of development and technological improvements in the field of genomic sequencing:

– Development of tools for the integrated analysis of massive DNA sequencing data, including those aimed at facilitating genetic diagnosis. 

– Evaluation of new sequencing technologies for their approach to the patient in the hospital setting.

1. Diagnosis and genetic factors involved in the development of severe COVID-19:

– Identification of the genetic and immune causes involved in the susceptibility and development of severe forms of COVID-19, as well as in adverse responses resulting from vaccines, through GWAS studies and whole exome/genome sequencing.

– Diagnostic improvements and genomic surveillance of SARS-CoV-2 and other respiratory viruses.

Funded projects

• Functional evaluation of associated variants and complementary genomic analyses to identify genes involved in acute respiratory distress syndrome (PI20/00876). PI: Carlos Flores. Carlos III Health Institute (2021-2023, €159,720)
• Clinical and genetic modifiers of COVID-19 severity in patients with asthma (PIFIISC20/57). PI: Carlos Flores, Ariel Callero Viera. Canary Islands Foundation Institute of Health Research of the Canary Islands (2021-2022, extended until 30/11/2023, €18,116.51)
• Analysis of pharmacogenomic variants using next-generation sequencing data (PHARMA-CAN). SUBPROJECT 1: Pharmacogenetics in the clinical setting: management, research and validation of the methodology (ProID2021010084). PI: Itahisa Marcelino. Canary Islands Agency for Research, Innovation and the Information Society, ACIISI (03/2021 – 04/2023, €68,365.15 total amount)
• Identification of the genetic basis of Type 1 Diabetes in the Canary Islands. PI: Itahisa Marcelino. DISA Foundation (2022-2023, €25,000)
• ProCIBERdexa: CIBER multidisciplinary project to optimize dexamethasone dosage in patients with respiratory failure (IC20/00062). PI: Jesús Villar Hernández (Carlos Flores, coordinator of subproject 3). Carlos III Health Institute (2021-2023)
• Enhancing whole genome sequencing (WGS) and/or reverse transcription polymerase chain reaction (RT-PCR) national infrastructures and capacities to respond to the COVID-19 pandemic and future health threats (101113109-RELECOV 2.0). PI: Inmaculada Casas (Carlos A. Flores Infante and Julia Alcoba Florez are Principal Investigators for the activities of the Collaborating Institution). European Health and Digital Executive Agency (HADEA) (01/07/2023 – 30/06/2025, €2,200,421.27)
• iDATA-MP. IMPaCT Data Science Program (IMP/00019). PI: Alfonso Valencia Herrera (Carlos Flores PI for the Canary Islands). Carlos III Health Institute. 2021-2023. €4,549,380

Publications 2023

• Oldham JM, Allen RJ, Lorenzo-Salazar JM, Molyneaux PL, Ma SF, Joseph C, Kim JS, Guillen-Guio B, Hernández-Beeftink T, Kropski J, Huang Y, Lee CT, Adegunsoy A, Pugashetti JV, Linderholm A, Vo V, Strek M, Hubbard R, Hirani N, Whyte MKB, Hart S, Nicholson A, Parfrey H, Rassl D, Wallace W, Valenzi E, Zhang Y, Kaminski N, Wolters P, Molina-Molina M, Martinez FJ, Hall I, Tobin MD, Maher TM, Blackwell T, Yaspan B, Jenkins RG, Flowers C, Wain LV, Noth I. PCSK6 and Survival in Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine. 2023;207(11):1515-1524. DOI: 10.1164/rccm.202205-0845OC
• Allen RJ, Oldham JM, Jenkins DA, Leavy QC, Guillen-Guio B, Melbourne CA, Ma SF, Jou J, Kim JS, CleanUP-IPF Investigators of the Pulmonary Trials Cooperative, Fahy WA, Oballa E, Hubbard RB, Navaratnam V, Braybrooke R, Saini G, Roach KM, Tobin MD, Hirani N, Whyte MKB, Kaminski N, Zhang Y, Martinez FJ, Linderholm AL, Adegunsoye A, Strek ME, Maher TM, Molyneaux PL, Flowers C, Noth I, Jenkins RG, Wain LV. Genome-wide analysis of longitudinal lung function and gas transfer in individuals with idiopathic pulmonary fibrosis. Lancet Respiratory Medicine. 2023;11(1):65-73. DOI: 10.1016/S2213-2600(22)00251-X
• García-Olivares V, Rubio-Rodríguez LA, Muñoz-Barrera A, Díaz-de Usera A, Jáspez D, Iñigo-Campos A, Rodríguez Pérez MdC, Cabrera de Leon A, Lorenzo-Salazar JM, González-Montelongo R, Cabrera VM, Flowers C. Digging into the admixture strata of current-day Canary Islanders based on mitogenomes. iScience. 2023;26(1): 105907. DOI: 10.1016/j.isci.2022.105907
• Read more Michailidis E, Moreews M, Seeleuthner Y, Bilguvar K, Mane S, Flowers C, Zhang Y, Arias AA, Bailey R, Schlüter A, Milisavljevic B, Bigio B, Voyer TL, Materna M, Gervais A, Moncada-Velez M, Pala F, Lazarov T, Levy R, Neehus AL, Rosain J, Peel J, Chan YH, Morin MP, Pino-Ramirez RM, Belkaya S, Lorenzo L, Anton J, Delafontaine S, Toubiana J, Bajolle F, Fumado V, DeDiego ML, Fidouh N, Rozenberg F, Perez-Tur J, Chen S, Evans T, Geissmann F, Lebon P, Weiss SR, Bonnet D, Duval Dalgard C, Bustamante J, Puel A, Boisson-Dupuis S, Boisson B, Maniatis T, Zhang Q, Bastard P, Notarangelo L, Beziat V, Perez de Diego R, Rodriguez-Gallego C, Su HC, Lifton R, Jouanguy E, Cobat A, Alsina L, Keles S, Haddad E, Abel L, Belot A, Quintana-Murci L, Rice CM, Silverman RH, Zhang SY, Casanova JL. Inherited deficiency of the OAS–RNase L pathway in SARS-CoV-2–related multisystem inflammatory syndrome in children. Science. 2023;379(6632): eabo3627. DOI: 10.1126/science.abo3627
• Pairo-Castineira E, Rawlik K, Bretherick AD, Qi T, Wu Y, Nassiri I, McConkey GA, Zechner M, Klaric L, Griffiths F, Oosthuyzen W, Kousathanas A, Richmond A, Millar J, Russell CD, Malinauskas T, Thwaites R, Morrice K, Keating S, Maslove D, Nichol A, Semple MG, Knight J, Shankar-Hari M, Summers C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM, Begg C, Walsh T, Tenesa A, Flowers C, Riancho JA, Rojas-Martinez A, Lapunzina P, GenOMICC Investigators, SCOURGE Consortium, ISARIC4C Investigators, The 23andMe COVID-19 Team, Yang J, Ponting CP, Wilson JF, Vitart V, Abedalthagafi M, Luchessi A, Parra E, Cruz-Guerrero R, Carracedo A, Fawkes A, Murphy L, Rowan K, Pereira AC, Law A, Fairfax B, Hendry SC, Baillie JK. GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19. Nature. 2023;617(7962):764-768. DOI: 10.1038/s41586-023-06034-3
• García-Olivares V, Muñoz-Barrera A, Rubio Rodríguez LA, Jáspez D, Díaz de-Usera A, Íñigo-Campos A, Veeramah KR, Alonso S, Thomas MG, González-Montelongo R, Lorenzo-Salazar JM, Flowers C. Benchmarking of human Y-chromosomal haplogroup classifiers with whole-genome and whole-exome sequence data. Computational and Structural Biotechnology Journal. 2023;21:4613-4618. DOI: 10.1016/j.csbj.2023.09.012
• Matuozzo D, Talouarn E, Marchal A, Manry J, Seeleuthner Y, Zhang Y, Bolze A, Chaldebas M, Milisavljevic B, Zhang P, Gervais A, Bastard P, Asano T, Bizien L, Barzaghi F, Abolhassani H, Tayoun AA, Aiuti A, Darazam I, Allende LM, Alonso-Arias R, Arias AA, Aytekin G, Bergman P, Bondesan S, Bryceson YT, Bustos IG, Cabrera-Marante O, Carcel S, Carrera P, Casari G, Chaïbi K, Colobran R, Condino-Neto A, Covill LE, El Zein L, Flowers C, Gregersen PK, Gut M, Haerynck F, Halwani R, Hancerli S, Hammarström L, Hatipoğlu N, Karbuz A, Keles S, Kyheng C, Leon-Lopez R, Franco JL, Mansouri D, Martinez-Picado J, Akcan OM, Migeotte I, Morange PE, Morelle G, Martin-Nalda A, Novelli G, Novelli A, Ozcelik T, Palabiyik F, Pan-Hammarström Q, Pérez-de-Diego R, Planas-Serra L, Pleguezuelo DE, Prando C, Pujol A, Reyes LF, Rivière JG, Rodriguez-Gallego C, Rojas J, Rovere-Querini P, Schlüter A, Shahrooei M, Sobh A, Soler-Palacin P, Tandjaoui-Lambiotte Y, Tipu I, Tresoldi C, Troy J, van de Beek D, Zatz M, Zawadzki P, Al-Muhsen SZ, Baris-Feldman H, Butte MJ, Constantinescu SN, Cooper MA, Dalgard CL, Fellay J, Heath JR, Lau YL, Lifton RP, Maniatis T, Mogensen TH, von Bernuth H, Lermine A, Vidaud M, Boland A, Deleuze JF, Nussbaum R, Kahn-Kirby A, Mentre F, Tubiana S, Gorochov G, Tubach F, Hausfater P, COVID Human Genetic Effort, COVIDeF Study Group, French COVID Cohort Study Group, CoV-Contact Cohort, COVID-STORM Clinicians, COVID Clinicians, Orchestra Working Group, Amsterdam UMC Covid-19 Biobank, NIAID-USUHS COVID Study Group, Meyts I, Zhang SY, Puel A, Notarangelo LD, Boisson-Dupuis S, Su HC, Boisson B, Jouanguy E, Casanova JL, Zhang Q, Abel L, Cobat A. Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19. Genome Medicine. 2023;15:22. DOI: 10.1186/s13073-023-01173-8
• Tangye SG, COVID Human Genetic Effort (Flowers C). Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity. Journal of Allergy and Clinical Immunology. 2023;151:818-831. DOI: 10.1016/j.jaci.2022.11.010
• García-García A, Pérez de Diego R, Flowers C, Rinchai D, Solé-Violán J, Deyà-Martínez A, García-Solis B, Lorenzo-Salazar JM, Hernández-Brito E, Lanz AL, Moens L, Bucciol G, Almuqamam M, Domachowske JB, Colino E, Santos-Perez JL, Marco FM, Pignata C, Bousfiha A, Turvey SE, Bauer S, Haerynck F, Ocejo-Vinyals JG, Lendinez F, Prader S, Naumann-Bartsch N, Pachlopnik Schmid J, Biggs CM, Hildebrand K, Dreesman A, Cárdenes MA, Ailal F, Benhsaien I, Giardino G, Molina-Fuentes A, Fortuny C, Madhavarapu S, Conway DH, Prando C, Schidlowski L, Martínez de Saavedra Álvarez MT, Alfaro R, Rodríguez de Castro F, ESID Registry Working Party, COVID Human Genetic Effort, Meyts I, Hauck F, Puel A, Bastard P, Boisson B, Jouanguy E, Abel L, Cobat A, Zhang Q, Casanova JL, Alsina L, Rodríguez-Gallego C. Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia. Journal of Experimental Medicine. 2023;220(5):e20220170. DOI: 10.1084/jem.20220170
• Bucciol G, Moens L, Ogishi M, Rinchai D, Matuozzo D, Momenilandi M, Kerrouche N, Cale CM, Treffeisen ER, Al Salamah M, Al Saud BK, Lachaux A, Duclaux-Loras R, Meignien M, Bousfiha A, Benhsaien I, Shcherbina A, Roppelt A, COVID Human Genetic Effort* (Flowers C), Gothe F, Houhou-Fidouh N, Hackett S, Bartnikas LM, Maciag MC, Alosaimi MF, Chou J, Mohammed RW, Freij BJ, Jouanguy E, Zhang SY, Boisson-Dupuis S, Béziat V, Zhang Q, Duncan CJA, Hambleton S, Casanova JL, Meyts I. Inherited complete human STAT2 deficiency underlies inflammatory viral diseases. Journal of Clinical Investigation. 2023;133(12):e168321. DOI: 10.1172/JCI168321
• Reynolds CJ, Del Greco F, Allen RJ, Flowers C, Jenkins RG, Maher TM, Molyneaux PL, Noth I, Oldham JM, Wain LV, An J, Ong JS, MacGregor S, Yates TA, Cullinan P, Minelli C. The causal relationship between gastro-esophageal reflux disease and idiopathic pulmonary fibrosis: A bidirectional two-sample Mendelian randomization study. European Respiratory Journal. 2023;61(5):2201585. DOI: 10.1183/13993003.01585-2022
• Muñoz-Barrera A, Ciuffreda L, Alcoba-Florez J, Rubio-Rodríguez LA, Rodríguez-Pérez H, Gil-Campesino H, García-Martínez de Artola D, Salas-Hernández J, Rodríguez-Núñez J, Íñigo-Campos A, García-Olivares V, Díez-Gil O, González-Montelongo R, Valenzuela-Fernández A, Lorenzo-Salazar JM, Flowers C. Bioinformatic approaches to draft the viral genome sequence of Canary Islands cases related to the multicountry mpox virus 2022-outbreak. Computational and Structural Biotechnology Journal. 2023;21:2197-2203. DOI: 10.1016/j.csbj.2023.03.020
• Ciuffreda L, Lorenzo-Salazar JM, García-Martínez de Artola D, Gil-Campesino H, Alcoba-Florez J, Rodríguez-Pérez H, Íñigo-Campos A, Salas-Hernández J, Rodríguez-Nuñez J, Muñoz-Barrera A, Valenzuela-Fernández A, Díez-Gil O, González-Montelongo R, Flowers C. Reinfection rate and disease severity of the BA.5 Omicron SARS-CoV-2 lineage compared to previously circulating lineages of concern in the Canary Islands (Spain). Emerging Microbes and Infections. 2023;12(1): 2202281. DOI: 10.1080/22221751.2023.2202281
• Alonso-Gonzalez A, Tosco-Herrera E, Molina-Molina M, Flowers C. Idiopathic pulmonary fibrosis and the role of genetics in the era of precision medicine. Frontiers in Medicine. 2023;10: 1152211. DOI: 10.3389/fmed.2023.1152211
• Su HC, Jing H, Zhang Y, COVID Human Genetic Effort* (Flowers C), Casanova JL. Interfering with interferons: A critical mechanism for critical COVID-19 pneumonia. Annual Review of Immunology. 2023;41:561-585. DOI: 10.1146/annurev-immunol-101921-050835
• Cobat A, Zhang Q, COVID Human Genetic Effort* (Flowers C), Abel L, Casanova JL, Fellay J. Human Genomics of COVID-19 pneumonia: contributions of rare and common variants. Annual Review of Biomedical Data Science. 2023;6:465-486. DOI: 10.1146/annurev-biodatasci-020222-021705
• Alemany-Navarro M, Diz-de Almeida S, Cruz R, Riancho JA, Rojas-Martínez A, Lapunzina P, Flowers C, Scourge Cohort Group, Carracedo A. Psychiatric polygenic risk as a predictor of COVID-19 risk and severity: insight into the genetic overlap between schizophrenia and COVID-19. Translational Psychiatry. 2023;13(1):189. DOI: 10.1038/s41398-023-02482-7
• Suarez-Pajes E, Tosco-Herrera E, Ramirez-Falcon M, Gonzalez-Barbuzano S, Hernandez-Beeftink T, Guillen-Guio B, Villar J, Flowers C. Genetic determinants of the acute respiratory distress syndrome. Journal of Clinical Medicine. 2023;12(11):3713. DOI: 10.3390/jcm12113713
• Gao L, Rafaels N, Dudenkov TM, Damarla M, Damico R, Maloney JP, Moss M, Martin GS, Sevransky J, Shanholtz C, Herr DL, Garcia JGN, Hernandez-Beeftink T, Villar J, Flowers C, Beaty TH, Brower R, Hassoun PM, Barnes KC. Xanthine oxidoreductase gene polymorphisms are associated with high risk of sepsis and organ failure. Respiratory Research. 2023;24(1):177. DOI: 10.1186/s12931-023-02481-8
• Castro-Santos P, Rojas-Martinez A, Riancho JA, Lapunzina P, Flowers C, SCOURGE Cohort Group, Carracedo A, Díaz-Peña R. HLA-A*11:01 and HLA-C*04:01 are associated with severe COVID-19. HLA. 2023;102(6):731-739. DOI: 10.1111/tan.15160
• Lawler PR, Manvelian G, Coppi A, Damask A, Cantor MN, Ferreira MAR, Paulding C, Banerjee N, Li D, Jorgensen S, Attre R, Carey DJ, Krebs K, Milani L, Hveem K, Damås JK, Solligård E, Stender S, Tybjærg-Hansen A, Nordestgaard BG, Hernandez-Beeftink T, Rogne T, Flowers C, Villar J, Walley KR, Liu VX, Fohner A, Lotta LA, Kyratsous CA, Sleeman MW, Scemama M, DelGizzi R, Pordy R, Horowitz JE, Baras A, Martin GS, Steg PG, Schwartz GG, Szarek M, Goodman SG. Pharmacologic and genetic down-regulation of proprotein convertase subtilisin/kexin type 9 and survival from sepsis. Critical Care Explorations. 2023;5(11):e0997. DOI: 10.1097/CCE.00000000000000997
• Le Voyer T, Parent AV, Liu Riller Q, Imberti L, Delmonte OM, Müller G, Keller B, Orrego J, Franco Gallego WA, et. to the (Flowers C). Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency. Nature. 2023;623(7988):803-813. DOI: 10.1038/s41586-023-06717-x
• Bucciol G, Abel L, Al-Muhsen S, Aiuti A, Al-Mulla F, Andreakos E, COVID Human Genetic Effort* (Flowers C). Inherited and acquired errors of type I interferon immunity govern susceptibility to COVID-19 and multisystem inflammatory syndrome in children. Journal of Allergy and Clinical Immunology. 2023;151(4):832-40. DOI: 10.1016/J.JACI.2023.02.003
• Almeida González D, Rodríguez-Pérez MDC, Fuentes Ferrer M, Cuevas Fernández FJ, Marcelino Rodríguez I, Cabrera de León A. Irisin, in women and men: blood pressure, heart rate, obesity and insulin resistance. Frontiers in Endocrinology. 2023 Jun;14. DOI: 10.3389/FENDO.2023.1193110

Other representative publications from recent years

• Wagner J, Olson ND, Harris L, McDaniel J, Cheng H, Fungtammasan A, Hwang YC, Gupta R, Wenger AM, Rowell WJ, Khan ZM, Farek J, Zhu Y, Pisupati A, Mahmoud M, Xiao C, Yoo B, Sahraeian SME, Miller DE, Jáspez D, Lorenzo-Salazar JM, Muñoz-Barrera A, Rubio-Rodríguez LA, Flowers C, Narzisi G, Evani US, Clarke WE, Lee J, Ebbert MTW, Shumate A, Li H, Chin CS, Zook JM, Sedlazeck FJ. Curated variation benchmarks for challenging medically relevant autosomal genes. Nature Biotechnology. 2022 May;40(5):672-680. DOI: 10.1038/s41587-021-01158-1
• Hernandez-Beeftink T, Guillen-Guio B, Lorenzo-Salazar JM, Corrales A, Suarez-Pajes E, Feng R, Rubio-Rodríguez LA, Paynton ML, Cruz-Guerrero R, García-Laorden MI, Prieto-González M, Rodríguez-Pérez A, Carriedo D, Blanco J, Ambrós A, González-Higueras E, Espinosa E, Muriel A, Tamayo E, Martin MM, Lorente L, Domínguez D, García de Lorenzo A, Giannini HM, Reilly JP, Jones TK, Añón JM, Soro M, Carracedo A, Wain LV, Meyer NJ, Villar J, Flowers C. A Genome-Wide Association Study of Survival in Patients with Sepsis. Critical Care. 2022 Nov 5;26(1):341. DOI: 10.1186/s13054-022-04208-5
• Rodríguez-Pérez H, Ciuffreda L, Flowers C. NanoCLUST: a species-level analysis of 16S rRNA nanopore sequencing data. Bioinformatics. 2021 Jul;37(11):1600-1601. DOI: 10.1093/bioinformatics/btaa900
• Guillen-Guio B, Lorenzo-Salazar JM, Ma SF, Hou PC, Hernandez-Beeftink T, Corrales A, García-Laorden MI, Jou J, Espinosa E, Muriel A, Domínguez D, Lorente L, Martín MM, Rodríguez-Gallego C, Solé-Violán J, Ambrós A, Carriedo D, Blanco J, Añón JM, Reilly JP, Jones TK, Ittner CAG, Feng R, Schöneweck F, Kiehntopf M, Noth I, Scholz M, Brunkhorst FM, Scherag A, Meyer NJ, Villar J, Flowers C. Genome-wide association study of sepsis-associated acute respiratory distress syndrome in individuals of European ancestry. Lancet Respir Med. 2020 Mar;8(3):258-266. DOI: 10.1016/S2213-2600(19)30368-6
• Guillen-Guio B, Lorenzo-Salazar JM, González-Montelongo R, Díaz-de Usera A, Marcelino-Rodríguez I, Corrales A, Cabrera de León A, Alonso S, Flowers C. Genomic analyzes of human European diversity at the southwestern edge: isolation, African influence and disease associations in the Canary Islands. Molecular Biology and Evolution. 2018 Dec;35(12):3010-3026. DOI: 10.1093/molbev/msy190