PRINCIPAL INVESTIGATOR

POSTDOCTORAL CLINICAL COLLABORATORS:

• Judith Mª López Fernández, MD, PhD (Attending Physician, Endocrinology Service, HUC)
• Iván Ferraz Amaro, MD, PhD (Attending Physician, Rheumatology Service, HUC)

EXTERNAL POSTDOCTORAL COLLABORATORS:

• Javier Rafael Castro Hernández, PhD (PI Project: Role of autophagy in the regulation of intercellular junctions mediated by alpha 2 adrenergic receptors in endothelial cells. – «Papel de la autofagia en la regulación de las uniones intercelulares mediadas por los receptores alpha2 adrenérgicos en células endoteliales» FUNCANIS 24,500 €. 2018-2020)

PHD STUDENTS AND TRAINEES:

• María Teresa Arce Franco (Predoctoral Researcher, The Canary Islands Health Research Institute Foundation, FIISC. Role of Alpha 2 adrenergic receptor subtypes in the acute and joint inflammatory response in vivo – «Papel de los subtipos de receptores alpha2 adrenérgicos en la regulación de la respuesta inflamatoria aguda y articular in vivo«).
• Sergio Ivan Santos Concepción (Predoctoral Researcher, The Canary Islands Health Research Institute Foundation, FIISC. Role of Alpha 2 adrenergic receptor subtypes in the acute and joint inflammatory response in vivo – «Papel de los subtipos de receptores alpha2 adrenérgicos en la regulación de la respuesta inflamatoria aguda y articular in vivo»).

TECHNICAL AND ADMINISTRATIVE STAFF:

• Elsa González Oramas (Administrative, Project Manager, Predoctoral Researcher, FIISC)

RESEARCH LINES:

• Role of free oxygen radicals in regulating first phase inflammatory responses.
• In vivo effect of anti-L-selectin substances in neutrophil migration.
• Modulation of the acute inflammatory response by the Alpha 2 adrenergic receptor.
• Role of B cell secreted soluble factors, cytokines and chemokines in the pathogenesis of rheumatoid arthritis.
• The capacity of resident pancreatic tissue stem cells to differentiate into adult endocrine pancreatic cells.
• Modulation of the acute and chronic inflammatory response by LXR receptors.
• Physical activity in patients with chronic joint diseases: a link between clinical activity and the capacity for movement.

FUNDED PROJECTS:

• Role of Alpha 2 adrenergic receptor subtypes in the acute and joint inflammatory response in vivo (“Papel de los subtipos de receptores alpha2 adrenérgicos en la regulación de la respuesta inflamatoria aguda y articular in vivo”). PI: Federico Díaz. Institute of Health Carlos III (2016-2019, 90,000 €).

PUBLICATIONS 2019:

• Sanchez-Piedra C,Hernández Miguel MV,Manero J,Roselló R,Sánchez-Costa JT,Rodríguez-Lozano C,Campos C,Cuende E,Fernández-Lopez JC,Bustabad S, Martín Domenech R,Pérez-Pampín E,Del Pino-Montes J,Millan-Arciniegas AM,Díaz-González F,Gómez-Reino JJ; On behalf of the BIOBADASER Study Group. Objectives and methodology of BIOBADASER phase III [Objetivos y metodología de la fase III de BIOBADASER]. Reumatol Clin. 2019 Jul Aug;15(4):229-236. doi: 10.1016/j.reuma.2017.08.001
• Ferraz-Amaro I,Hernández-Hernández MV,Tejera-Segura B,Delgado-Frías E, Macía-Díaz M,Machado JD,Diaz-González F. Effect of IL-6 Receptor Blockade on Proprotein Convertase Subtilisin/Kexin Type-9 and Cholesterol Efflux Capacity in Rheumatoid Arthritis Patients. Horm Metab Res. 2019 Mar;51(3):200-209. doi: 10.1055/a-0833-4627
• Hernandez MV,Sanchez-Piedra C,Garcia-Magallon B,Cuende E,Manero J, Campos-Fernandez C,Martin-Domenech R,Del Pino-Montes J,Manrique S, Castro-Villegas MC,Ruiz-Montesinos D,Sanchez-Alonso F,Diaz-Gonzalez F,Cea-Calvo L,Gómez-Reino JJ;BIOBADASER Study Group.Factors associated with long- term retention of treatment with golimumab in a real-world setting: an analysis of the Spanish BIOBADASER registry. Rheumatol Int. 2019 Mar;39(3):509-515. doi: 10.1007/s00296-018-4177-z
• Domínguez-Luis MJ,Armas-González E,Herrera-García A,Arce-Franco M,Feria M,Vicente-Manzanares M,Martínez-Ruiz A,Sánchez-Madrid F,Díaz-González F. L-selectin expression is regulated by CXCL8-induced reactive oxygen species produced during human neutrophil rolling. Eur J Immunol. 2019 Mar;49(3):386-397. doi: 10.1002/eji.201847710
• López-Isac E,Acosta-Herrera M,Kerick M, Assassi S, Satpathy AT,Granja J, Mumbach MR,Beretta L, Simeón CP,Carreira P, Ortego-Centeno N,Castellvi I, Bossini-Castillo L,Carmona FD,Orozco G,Hunzelmann N,Distler JHW,Franke A, Lunardi C, Moroncini G,Gabrielli A,de Vries-Bouwstra J,Wijmenga C,KoelemanBPC, Nordin A,Padyukov L, Hoffmann-Vold AM,Lie B;European Scleroderma Group (Diaz-Gonzalez F). GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways. Nat Commun. 2019 Oct 31;10(1):4955. doi: 10.1038/s41467-019-12760-y
• Seoane-Mato D,Sánchez-Piedra C,Silva-Fernández L,Sivera F,Blanco FJ, PérezRuiz F,Juan-Mas A,Pego-Reigosa JM,Narváez J,Quilis Martí N,Cortés VerdúR, Antón-Pagés F,Quevedo Vila V,Garrido Courel L,Del Amo NDV,Paniagua Zudaire I,Añez Sturchio G,Medina Varo F,Ruiz Tudela MDM,Romero Pérez A, Ballina J,Brandy García A,Fábregas Canales D,Font Gayá T,Bordoy Ferrer C, González Álvarez B,Casas Hernández L,Álvarez Reyes F,Delgado Sánchez M,Martínez Dubois C,Sánchez-Fernández SÁ,Rojas Vargas LM,García MoralesPV,Olivé A,Rubio Muñoz P,Larrosa M,Navarro Ricos N, Graell Martín E,Chamizo E, Chaves Chaparro L,Rojas Herrera S,Pons Dolset J,Polo Ostariz MÁ,Ruiz-Alejos Garrido S,Macía Villa C, Cruz Valenciano A,González Gómez ML,Morcillo Valle M,Palma Sánchez D,Moreno Martínez MJ,Mayor González M,Atxotegi Sáenz deBuruaga J,Urionagüena Onaindia I,Blanco Cáceres BA,Díaz-González F,Bustabad Prevalence of rheumatic diseases in adult population in Spain (EPISER 2016 study): Aims and methodology [Prevalencia de enfermedades reumáticas en población adulta en España (estudio EPISER 2016). Objetivos y metodología]. Reumatol Clin. 2019 Mar – Apr;15(2):90-96. doi: 10.1016/j.reuma.2017.06.009
• Rodríguez-Lozano B,González-Febles J,Garnier-Rodríguez JL,Dadlani S,Bustabad-Reyes S,Sanz M,Sánchez-Alonso F,Sánchez-Piedra C,González-Dávila E,Díaz-González F. Association between severity of periodontitis and clinical activity in rheumatoid arthritis patients: A case-control study. Arthritis Res Ther. 2019 Jan18;21(1):27. doi: 10.1186/s13075-019-1808-z
• Rovin BH, Solomons N,Pendergraft WF 3rd,Dooley MA,Tumlin J,Romero-Diaz J, Lysenko L,Navarra SV,Huizinga RB;AURA-LV Study Group (Diaz-Gonzalez F). A randomized, controlled double-blind study comparing the efficacy and safety of dose-ranging voclosporin with placebo in achieving remission in patients with active lupus nephritis. Kidney Int. 2019 Jan;95(1):219-231. doi: 10.1016/j.kint.2018.08.025
• Urruticoechea-Arana A, Cobo-Ibáñez T,Villaverde-García V,Santos Gómez M,Loza E, Vargas-Osorio K,Fariñas Padrón L,Diaz-Gonzalez F,Calvo-Río V,Blanco R. Efficacy and safety of biological therapy compared to synthetic immunomodulatory drugs or placebo in the treatment of Behçet’s disease associated uveitis: a systematic review. Rheumatol Int. 2019 Jan;39(1):47-58. doi: 10.1007/s00296-018-4193-z
• Abad Hernández MÁ, Andreu JL, Balsa Criado A, Díaz-González F, Moreno Muelas JV, Queiro Silva R, Gómez-Reino JJ. Update of the Position Paper of the Spanish Society of Rheumatology on Biosimilar Drugs. Reumatol Clin. 2019 May 1. pii: S1699-258X(19)30059-2. doi: 10.1016/j.reuma.2019.03.007. [Epub ahead of print]

OTHER SELECTED PUBLICATIONS FROM THE LAST 10 YEARS:

• Álvaro-Gracia JM, Jover JA, García-Vicuña R, Carreño L, Alonso A, Marsal S, Blanco F, Martínez-Taboada VM, Taylor P, Martín-Martín C, DelaRosa O, Tagarro I, Díaz-González F. Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis (Cx611): results of a multicentre, dose escalation, randomised, single-blind, placebo-controlled phase Ib/IIa clinical trial. Ann Rheum Dis. 2017 Jan;76(1):196-202. doi:10.1136/annrheumdis-2015-208918
• Cutolo M, Myerson GE, Fleischmann RM, Liote F, Díaz-González F, Van den Bosch F, Mazo-Ortega H, Feist E, Shan K, Hu C, Stevens RM, Poder A. A phase III, randomized, controlled trial of Apremilast in patients with psoriatic arthritis: resilys of the PALACE 2 trial. JRheumatol. 2016 Sep;43(9):1724-34. doi:10.3899/jrheum.151376
• Armas-González E, Diaz-Martin A, Dominguez-Luis MJ, Arce Franco MT, Herrero Garcia A, Hernandez-Hernandez MV, Bustabad S, Usategui A, Pablos JL, Canete JD, Díaz-González F. Differential antigen-presenting B cell phenotypes from synovial microenvironment of patients with rheumatoid and psoriatic arthritis. J Rheumatol. 2015 Oct;42(10):1825-34. doi: 10.3899/jrheum.141577
• Delgado-Frias E, Lopez-Mejias R, Genre F, Ubilla B, Gomez Rodriguez-Bethencourt MA, González-Díaz A, de Vera-Gonzalez AM, Gonzalez-Rivero AF, Diaz-Gonzalez F, Gonzalez-Gay MA, Ferraz-Amato I. Relatioship between endothelial dysfunction and osteoprotegerin, vitamin D, and bone mineral density in patients with rheumatoid arthritis. Clin Exp Rheumatol. 2015 Mar-Apr;33(2):241-9
• Ferraz-Amaro I, Gonzalez-Gay MA, Diaz-González F. Retinol-binding Protein 4 in Rheumatoid Arthritis-related Insulin Resistance and β-cell Function. J Rheumatol. 2014 Apr;41(4):658-65. doi: 10.3899/jrheum.130834
• Herrera-García AM, Domínguez-Luis MJ, Arce-Franco M, Armas-González E, Álvarez de La Rosa D, Machado JD, Pec MK, Feria M, Barreiro O, Sánchez-Madrid F, Díaz-González F. Prevention of neutrophil extravasation by α2-adrenoceptor-mediated endothelial stabilization. J Immunol. 2014 Sep 15;193(6):3023-35. doi:10.4049/jimmunol.1400255