Responsible: Dr. José M. Padrón
Although compounds are provided from long-term establish collaborations with chemistry groups, we implemented our own synthesis programme devoted to obtain new analogues with an enhanced biological activity profile. The design of analogues is based on the previous results from our own research. With all the information we elaborate a list of chemical structures selected on the basis of stucture-activity relationship studies or rational design in silico. Then, we design the most appropriate chemical routes to prepare the analogues.
We focus on the synthesis of new small molecules for the study of their bioactivity. In our main line of research, we use α-amino acids as a source of chirality of natural origin (chiral pool) that we derivatize as a continuation line of the results derived from the doctoral thesis of Dr. Padrón.